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Associations between body mass index and development of metabolic disorders in fertile women--a nationwide cohort study.

Abstract

BACKGROUND

Metabolic disorders are relatively uncommon in young women, but may increase with obesity. The associations between body mass index (BMI) and risks of diabetes, hypertension, and dyslipidemia in apparently healthy, young women have been insufficiently investigated, and are the aims of this study.

METHODS AND RESULTS

Women giving birth during the years 2004-2009, with no history of cardiovascular disease, renal insufficiency, pregnancy-associated metabolic disorders, diabetes, hypertension, or dyslipidemia were identified in nationwide registers. Women were categorized as underweight (BMI<18.5 kg/m(2)), normal weight (BMI=18.5 to <25 kg/m(2)), overweight (BMI=25 to <30 kg/m(2)), obese-I (BMI=30 to <35 kg/m(2)), obese-II (BMI=35 to <40 kg/m(2)), and obese-III (BMI≥40 kg/m(2)). We assessed risks by Poisson regression models (adjusted for age, calendar year; reference=normal weight). The cohort comprised 252 472 women with a median age of 30.4 years (IQR=27.2;33.7) and a median follow-up of 5.5 years (IQR=3.9;6.8). In total, 2029 women developed diabetes, 3133 women developed hypertension, and 1549 women developed dyslipidemia. Rate ratios (RRs) of diabetes were: 0.84 (95% confidence interval [CI]=0.62 to 1.14) for underweight, 2.63 (CI=2.36 to 2.93) for overweight, 4.83 (CI=4.27 to 5.47) for obese grade-I, 7.17 (CI=6.10 to 8.48) for obese grade-II, and 6.93 (CI=5.47 to 8.79) for obese grade-III women. For hypertension, corresponding RRs were 0.86 (CI=0.69 to 1.09), 1.82 (CI=1.67 to 1.98), 2.81 (CI=2.52 to 3.13), 3.92 (CI=3.36 to 4.56), and 5.69 (CI=4.71 to 6.89), and for dyslipidemia, RRs were 1.18 (CI=0.85 to 1.65), 2.01 (CI=1.75 to 2.31), 3.11 (CI=2.61 to 3.70), 4.64 (CI=3.66 to 5.87), and 3.72 (CI=2.53 to 5.48).

CONCLUSIONS

In this nationwide study of fertile, apparently healthy women, pre-pregnancy BMI was strongly associated with an increased risk of diabetes, hypertension, and dyslipidemia within 5.5 years following childbirth.

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  • Authors+Show Affiliations

    ,

    Department of Cardiology, Gentofte University Hospital, Copenhagen, Denmark.

    , , , , , , ,

    Source

    MeSH

    Adult
    Age Factors
    Body Mass Index
    Denmark
    Diabetes Mellitus
    Dyslipidemias
    Female
    Fertility
    Health Surveys
    Humans
    Hypertension
    Incidence
    Kaplan-Meier Estimate
    Multivariate Analysis
    Obesity
    Odds Ratio
    Parity
    Pregnancy
    Prognosis
    Risk Assessment
    Risk Factors
    Sex Factors
    Time Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    24721798

    Citation

    Schmiegelow, Michelle Dalgas, et al. "Associations Between Body Mass Index and Development of Metabolic Disorders in Fertile Women--a Nationwide Cohort Study." Journal of the American Heart Association, vol. 3, no. 2, 2014, pp. e000672.
    Schmiegelow MD, Andersson C, Køber L, et al. Associations between body mass index and development of metabolic disorders in fertile women--a nationwide cohort study. J Am Heart Assoc. 2014;3(2):e000672.
    Schmiegelow, M. D., Andersson, C., Køber, L., Andersen, S. S., Norgaard, M. L., Jensen, T. B., ... Torp-Pedersen, C. (2014). Associations between body mass index and development of metabolic disorders in fertile women--a nationwide cohort study. Journal of the American Heart Association, 3(2), pp. e000672. doi:10.1161/JAHA.113.000672.
    Schmiegelow MD, et al. Associations Between Body Mass Index and Development of Metabolic Disorders in Fertile Women--a Nationwide Cohort Study. J Am Heart Assoc. 2014 Apr 10;3(2):e000672. PubMed PMID: 24721798.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Associations between body mass index and development of metabolic disorders in fertile women--a nationwide cohort study. AU - Schmiegelow,Michelle Dalgas, AU - Andersson,Charlotte, AU - Køber,Lars, AU - Andersen,Søren Skøtt, AU - Norgaard,Mette Lykke, AU - Jensen,Thomas Bo, AU - Gislason,Gunnar, AU - Berger,Siv Mari, AU - Torp-Pedersen,Christian, Y1 - 2014/04/10/ PY - 2014/4/12/entrez PY - 2014/4/12/pubmed PY - 2014/11/19/medline KW - body mass index KW - diabetes KW - hypercholesterolemia KW - hypertension KW - women SP - e000672 EP - e000672 JF - Journal of the American Heart Association JO - J Am Heart Assoc VL - 3 IS - 2 N2 - BACKGROUND: Metabolic disorders are relatively uncommon in young women, but may increase with obesity. The associations between body mass index (BMI) and risks of diabetes, hypertension, and dyslipidemia in apparently healthy, young women have been insufficiently investigated, and are the aims of this study. METHODS AND RESULTS: Women giving birth during the years 2004-2009, with no history of cardiovascular disease, renal insufficiency, pregnancy-associated metabolic disorders, diabetes, hypertension, or dyslipidemia were identified in nationwide registers. Women were categorized as underweight (BMI<18.5 kg/m(2)), normal weight (BMI=18.5 to <25 kg/m(2)), overweight (BMI=25 to <30 kg/m(2)), obese-I (BMI=30 to <35 kg/m(2)), obese-II (BMI=35 to <40 kg/m(2)), and obese-III (BMI≥40 kg/m(2)). We assessed risks by Poisson regression models (adjusted for age, calendar year; reference=normal weight). The cohort comprised 252 472 women with a median age of 30.4 years (IQR=27.2;33.7) and a median follow-up of 5.5 years (IQR=3.9;6.8). In total, 2029 women developed diabetes, 3133 women developed hypertension, and 1549 women developed dyslipidemia. Rate ratios (RRs) of diabetes were: 0.84 (95% confidence interval [CI]=0.62 to 1.14) for underweight, 2.63 (CI=2.36 to 2.93) for overweight, 4.83 (CI=4.27 to 5.47) for obese grade-I, 7.17 (CI=6.10 to 8.48) for obese grade-II, and 6.93 (CI=5.47 to 8.79) for obese grade-III women. For hypertension, corresponding RRs were 0.86 (CI=0.69 to 1.09), 1.82 (CI=1.67 to 1.98), 2.81 (CI=2.52 to 3.13), 3.92 (CI=3.36 to 4.56), and 5.69 (CI=4.71 to 6.89), and for dyslipidemia, RRs were 1.18 (CI=0.85 to 1.65), 2.01 (CI=1.75 to 2.31), 3.11 (CI=2.61 to 3.70), 4.64 (CI=3.66 to 5.87), and 3.72 (CI=2.53 to 5.48). CONCLUSIONS: In this nationwide study of fertile, apparently healthy women, pre-pregnancy BMI was strongly associated with an increased risk of diabetes, hypertension, and dyslipidemia within 5.5 years following childbirth. SN - 2047-9980 UR - https://www.unboundmedicine.com/medline/citation/24721798/Associations_between_body_mass_index_and_development_of_metabolic_disorders_in_fertile_women__a_nationwide_cohort_study_ DB - PRIME DP - Unbound Medicine ER -