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Safety and tolerance of a new extensively hydrolyzed rice protein-based formula in the management of infants with cow's milk protein allergy.
Eur J Pediatr. 2014 Sep; 173(9):1209-16.EJ

Abstract

Guidelines recommend the use of extensively hydrolyzed cow's milk protein-based formulas (eHF) in the treatment of infants with cow's milk protein allergy (CMPA). Extensively hydrolyzed rice protein infant formula (eRHF) has recently become available and could offer a valid alternative. A prospective trial was performed to evaluate the hypo-allergenicity and safety of a new eRHF in infants with a confirmed CMPA. Patients were fed the study formula for 6 months. Clinical tolerance of the eRHF was evaluated with a symptom-based score (SBS) and growth (weight and length) was monitored. Forty infants (mean age, 3.4 months; range, 1-6 months) with CMPA confirmed by a food challenge were enrolled. All infants tolerated the eRHF and the SBS significantly decreased as of the first month of intervention. Moreover, the eRHF allowed a catch-up to normal weight gain as of the first month as well as a normalization of the weight-for-age, weight-for length, and BMI z-scores within the 6-month study period.

CONCLUSION

In accordance with current guidelines, this eRHF was tolerated by more than 90 % of children with proven CMPA with a 95 % confidence interval. This eRHF is an adequate and safe alternative to cow milk-based eHF.

Authors+Show Affiliations

Department of Pediatrics, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium, yvan.vandenplas@uzbrussel.be.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24723091

Citation

Vandenplas, Yvan, et al. "Safety and Tolerance of a New Extensively Hydrolyzed Rice Protein-based Formula in the Management of Infants With Cow's Milk Protein Allergy." European Journal of Pediatrics, vol. 173, no. 9, 2014, pp. 1209-16.
Vandenplas Y, De Greef E, Hauser B, et al. Safety and tolerance of a new extensively hydrolyzed rice protein-based formula in the management of infants with cow's milk protein allergy. Eur J Pediatr. 2014;173(9):1209-16.
Vandenplas, Y., De Greef, E., & Hauser, B. (2014). Safety and tolerance of a new extensively hydrolyzed rice protein-based formula in the management of infants with cow's milk protein allergy. European Journal of Pediatrics, 173(9), 1209-16. https://doi.org/10.1007/s00431-014-2308-4
Vandenplas Y, et al. Safety and Tolerance of a New Extensively Hydrolyzed Rice Protein-based Formula in the Management of Infants With Cow's Milk Protein Allergy. Eur J Pediatr. 2014;173(9):1209-16. PubMed PMID: 24723091.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Safety and tolerance of a new extensively hydrolyzed rice protein-based formula in the management of infants with cow's milk protein allergy. AU - Vandenplas,Yvan, AU - De Greef,Elisabeth, AU - Hauser,Bruno, AU - ,, Y1 - 2014/04/12/ PY - 2013/12/26/received PY - 2014/03/24/accepted PY - 2014/03/03/revised PY - 2014/4/12/entrez PY - 2014/4/12/pubmed PY - 2015/6/3/medline SP - 1209 EP - 16 JF - European journal of pediatrics JO - Eur J Pediatr VL - 173 IS - 9 N2 - UNLABELLED: Guidelines recommend the use of extensively hydrolyzed cow's milk protein-based formulas (eHF) in the treatment of infants with cow's milk protein allergy (CMPA). Extensively hydrolyzed rice protein infant formula (eRHF) has recently become available and could offer a valid alternative. A prospective trial was performed to evaluate the hypo-allergenicity and safety of a new eRHF in infants with a confirmed CMPA. Patients were fed the study formula for 6 months. Clinical tolerance of the eRHF was evaluated with a symptom-based score (SBS) and growth (weight and length) was monitored. Forty infants (mean age, 3.4 months; range, 1-6 months) with CMPA confirmed by a food challenge were enrolled. All infants tolerated the eRHF and the SBS significantly decreased as of the first month of intervention. Moreover, the eRHF allowed a catch-up to normal weight gain as of the first month as well as a normalization of the weight-for-age, weight-for length, and BMI z-scores within the 6-month study period. CONCLUSION: In accordance with current guidelines, this eRHF was tolerated by more than 90 % of children with proven CMPA with a 95 % confidence interval. This eRHF is an adequate and safe alternative to cow milk-based eHF. SN - 1432-1076 UR - https://www.unboundmedicine.com/medline/citation/24723091/Safety_and_tolerance_of_a_new_extensively_hydrolyzed_rice_protein_based_formula_in_the_management_of_infants_with_cow's_milk_protein_allergy_ L2 - https://dx.doi.org/10.1007/s00431-014-2308-4 DB - PRIME DP - Unbound Medicine ER -