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Human thyroglobulin autoantibodies of subclasses IgG2 and IgG4 bind to different epitopes on thyroglobulin.
Immunology. 1989 May; 67(1):129-31.I

Abstract

IgG autoantibodies to thyroglobulin (Tg) in the serum of patients with autoimmune thyroid disease only recognize a very limited number of epitopes, probably between four and six (Nye, Pontes De Carvalho & Roitt, 1980) on the large Tg molecule (660,000 MW), but attempts to characterize the epitopes have been unsuccessful so far (Male et al., 1985). The distribution of Tg autoantibodies between the IgG subclasses also tends to be restricted and individual patients possess characteristic 'fingerprints' of high affinity IgG1 and/or IgG4 Tg antibodies with smaller amounts of IgG2 Tg antibody (McLachlan et al., 1987, 1988). We have therefore investigated the possibility that Tg autoantibodies of different IgG subclasses interact with different epitopes on Tg.

Authors+Show Affiliations

Department of Medicine, University of Wales College of Medicine, Cardiff, U.K.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2472355

Citation

Fukuma, N, et al. "Human Thyroglobulin Autoantibodies of Subclasses IgG2 and IgG4 Bind to Different Epitopes On Thyroglobulin." Immunology, vol. 67, no. 1, 1989, pp. 129-31.
Fukuma N, McLachlan SM, Petersen VB, et al. Human thyroglobulin autoantibodies of subclasses IgG2 and IgG4 bind to different epitopes on thyroglobulin. Immunology. 1989;67(1):129-31.
Fukuma, N., McLachlan, S. M., Petersen, V. B., Kau, P., Bradbury, J., Devey, M., Bleasdale, K., Grabowski, P., & Smith, B. R. (1989). Human thyroglobulin autoantibodies of subclasses IgG2 and IgG4 bind to different epitopes on thyroglobulin. Immunology, 67(1), 129-31.
Fukuma N, et al. Human Thyroglobulin Autoantibodies of Subclasses IgG2 and IgG4 Bind to Different Epitopes On Thyroglobulin. Immunology. 1989;67(1):129-31. PubMed PMID: 2472355.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human thyroglobulin autoantibodies of subclasses IgG2 and IgG4 bind to different epitopes on thyroglobulin. AU - Fukuma,N, AU - McLachlan,S M, AU - Petersen,V B, AU - Kau,P, AU - Bradbury,J, AU - Devey,M, AU - Bleasdale,K, AU - Grabowski,P, AU - Smith,B R, PY - 1989/5/1/pubmed PY - 1989/5/1/medline PY - 1989/5/1/entrez SP - 129 EP - 31 JF - Immunology JO - Immunology VL - 67 IS - 1 N2 - IgG autoantibodies to thyroglobulin (Tg) in the serum of patients with autoimmune thyroid disease only recognize a very limited number of epitopes, probably between four and six (Nye, Pontes De Carvalho & Roitt, 1980) on the large Tg molecule (660,000 MW), but attempts to characterize the epitopes have been unsuccessful so far (Male et al., 1985). The distribution of Tg autoantibodies between the IgG subclasses also tends to be restricted and individual patients possess characteristic 'fingerprints' of high affinity IgG1 and/or IgG4 Tg antibodies with smaller amounts of IgG2 Tg antibody (McLachlan et al., 1987, 1988). We have therefore investigated the possibility that Tg autoantibodies of different IgG subclasses interact with different epitopes on Tg. SN - 0019-2805 UR - https://www.unboundmedicine.com/medline/citation/2472355/Human_thyroglobulin_autoantibodies_of_subclasses_IgG2_and_IgG4_bind_to_different_epitopes_on_thyroglobulin_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/2472355/ DB - PRIME DP - Unbound Medicine ER -