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The effects of catecholamine depletion on the neural response to fearful faces in remitted depression.
Int J Neuropsychopharmacol 2014; 17(9):1419-28IJ

Abstract

Recent evidence suggests that increased psychophysiological response to negatively valenced emotional stimuli found in major depressive disorder (MDD) may be associated with reduced catecholaminergic neurotransmission. Fourteen unmedicated, remitted subjects with MDD (RMDD) and 13 healthy control subjects underwent catecholamine depletion with oral α-methyl-para-tyrosine (AMPT) in a randomized, placebo-controlled, double-blind crossover trial. Subjects were exposed to fearful (FF) and neutral faces (NF) during a scan with [15O]H2O positron emission tomography to assess the brain-catecholamine interaction in brain regions previously associated with emotional face processing. Treatment with AMPT resulted in significantly increased, normalized cerebral blood flow (CBF) in the left inferior temporal gyrus (ITG) and significantly decreased CBF in the right cerebellum across conditions and groups. In RMDD, flow in the left posterior cingulate cortex (PCC) increased significantly in the FF compared to the NF condition after AMPT, but remained unchanged after placebo, whereas healthy controls showed a significant increase under placebo and a significant decrease under AMPT in this brain region. In the left dorsolateral prefrontal cortex (DLPFC), flow decreased significantly in the FF compared to the NF condition under AMPT, and increased significantly under placebo in RMDD, whereas healthy controls showed no significant differences. Differences between AMPT and placebo of within-session changes in worry-symptoms were positively correlated with the corresponding changes in CBF in the right subgenual prefrontal cortex in RMDD. In conclusion, this study provided evidence for a catecholamine-related modulation of the neural responses to FF expressions in the left PCC and the left DLPFC in subjects with RMDD that might constitute a persistent, trait-like abnormality in MDD.

Authors+Show Affiliations

Department of Psychiatric Neurophysiology,University Hospital of Psychiatry, University of Bern,Switzerland.Laureate Institute for Brain Research,Tulsa, OK, 74136,USA.University Hospital of Psychiatry, University of Bern,Switzerland.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24725805

Citation

Homan, Philipp, et al. "The Effects of Catecholamine Depletion On the Neural Response to Fearful Faces in Remitted Depression." The International Journal of Neuropsychopharmacology, vol. 17, no. 9, 2014, pp. 1419-28.
Homan P, Drevets WC, Hasler G. The effects of catecholamine depletion on the neural response to fearful faces in remitted depression. Int J Neuropsychopharmacol. 2014;17(9):1419-28.
Homan, P., Drevets, W. C., & Hasler, G. (2014). The effects of catecholamine depletion on the neural response to fearful faces in remitted depression. The International Journal of Neuropsychopharmacology, 17(9), pp. 1419-28. doi:10.1017/S1461145714000339.
Homan P, Drevets WC, Hasler G. The Effects of Catecholamine Depletion On the Neural Response to Fearful Faces in Remitted Depression. Int J Neuropsychopharmacol. 2014;17(9):1419-28. PubMed PMID: 24725805.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of catecholamine depletion on the neural response to fearful faces in remitted depression. AU - Homan,Philipp, AU - Drevets,Wayne C, AU - Hasler,Gregor, Y1 - 2014/04/14/ PY - 2014/4/15/entrez PY - 2014/4/15/pubmed PY - 2015/3/31/medline SP - 1419 EP - 28 JF - The international journal of neuropsychopharmacology JO - Int. J. Neuropsychopharmacol. VL - 17 IS - 9 N2 - Recent evidence suggests that increased psychophysiological response to negatively valenced emotional stimuli found in major depressive disorder (MDD) may be associated with reduced catecholaminergic neurotransmission. Fourteen unmedicated, remitted subjects with MDD (RMDD) and 13 healthy control subjects underwent catecholamine depletion with oral α-methyl-para-tyrosine (AMPT) in a randomized, placebo-controlled, double-blind crossover trial. Subjects were exposed to fearful (FF) and neutral faces (NF) during a scan with [15O]H2O positron emission tomography to assess the brain-catecholamine interaction in brain regions previously associated with emotional face processing. Treatment with AMPT resulted in significantly increased, normalized cerebral blood flow (CBF) in the left inferior temporal gyrus (ITG) and significantly decreased CBF in the right cerebellum across conditions and groups. In RMDD, flow in the left posterior cingulate cortex (PCC) increased significantly in the FF compared to the NF condition after AMPT, but remained unchanged after placebo, whereas healthy controls showed a significant increase under placebo and a significant decrease under AMPT in this brain region. In the left dorsolateral prefrontal cortex (DLPFC), flow decreased significantly in the FF compared to the NF condition under AMPT, and increased significantly under placebo in RMDD, whereas healthy controls showed no significant differences. Differences between AMPT and placebo of within-session changes in worry-symptoms were positively correlated with the corresponding changes in CBF in the right subgenual prefrontal cortex in RMDD. In conclusion, this study provided evidence for a catecholamine-related modulation of the neural responses to FF expressions in the left PCC and the left DLPFC in subjects with RMDD that might constitute a persistent, trait-like abnormality in MDD. SN - 1469-5111 UR - https://www.unboundmedicine.com/medline/citation/24725805/The_effects_of_catecholamine_depletion_on_the_neural_response_to_fearful_faces_in_remitted_depression_ L2 - https://academic.oup.com/ijnp/article-lookup/doi/10.1017/S1461145714000339 DB - PRIME DP - Unbound Medicine ER -