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Verrucous localized lymphedema of genital areas: clinicopathologic report of 18 cases of this rare entity.
J Am Acad Dermatol. 2014 Aug; 71(2):320-6.JA

Abstract

BACKGROUND

Localized lymphedema is a nonneoplastic condition associated with obesity and predominantly involving the legs. This condition has distinctive clinical and histologic features and only rarely has been mentioned in the dermatologic literature.

OBJECTIVE

We sought to evaluate the clinical and histopathologic features.

METHODS

The clinicopathologic features in patients with localized lymphedema of the genital region were studied.

RESULTS

We identified 18 patients with localized lymphedema clinically presenting as large polypoid or verrucous lesions. The patients were 5 men and 13 women with a mean age of 46.5 years. Twelve patients were obese at diagnosis. Thirteen patients presented with tumors involving the vulva, 4 patients with tumors in the penis and scrotum, and 1 patient with scrotal and pubic lesions. Histologically, all cases showed marked dermal edema along with dilated lymphatic spaces, fibroplasia, and verrucous epidermal changes (papillomatous and hyperplastic epidermis).

LIMITATIONS

Only 18 cases were included in our study.

CONCLUSIONS

This condition is an uncommon and recently described entity that could potentially be clinically and histologically misdiagnosed as a neoplasm; thus, it needs to be included in the differential diagnosis of polypoid and verrucous skin tumors with extensive dermal edema and fibroplasia.

Authors+Show Affiliations

Division of Dermatopathology, Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin. Electronic address: jplaza@mcw.edu.Department of Dermatology, Universidad Autonoma de Madrid, Fundación Jiménez Díaz, Madrid, Spain.Sikls's Department of Pathology Charles University Medical Faculty Hospital, Pilsen, Czech Republic.Department of Dermatology, Hospital General "Dr Manuel Gea González," Mexico City, Mexico.Sikls's Department of Pathology Charles University Medical Faculty Hospital, Pilsen, Czech Republic.Department of Dermatology, Hospital General "Dr Manuel Gea González," Mexico City, Mexico.Sikls's Department of Pathology Charles University Medical Faculty Hospital, Pilsen, Czech Republic.Division of Dermatopathology, Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin.Hospital Obrero, La Paz, Bolivia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24726400

Citation

Plaza, Jose A., et al. "Verrucous Localized Lymphedema of Genital Areas: Clinicopathologic Report of 18 Cases of This Rare Entity." Journal of the American Academy of Dermatology, vol. 71, no. 2, 2014, pp. 320-6.
Plaza JA, Requena L, Kazakov DV, et al. Verrucous localized lymphedema of genital areas: clinicopathologic report of 18 cases of this rare entity. J Am Acad Dermatol. 2014;71(2):320-6.
Plaza, J. A., Requena, L., Kazakov, D. V., Vega, E., Kacerovska, D., Reyes, G., Michal, M., Suster, S., & Sangueza, M. (2014). Verrucous localized lymphedema of genital areas: clinicopathologic report of 18 cases of this rare entity. Journal of the American Academy of Dermatology, 71(2), 320-6. https://doi.org/10.1016/j.jaad.2014.01.907
Plaza JA, et al. Verrucous Localized Lymphedema of Genital Areas: Clinicopathologic Report of 18 Cases of This Rare Entity. J Am Acad Dermatol. 2014;71(2):320-6. PubMed PMID: 24726400.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Verrucous localized lymphedema of genital areas: clinicopathologic report of 18 cases of this rare entity. AU - Plaza,Jose A, AU - Requena,Luis, AU - Kazakov,Dmitry V, AU - Vega,Elisa, AU - Kacerovska,Denisa, AU - Reyes,Gisela, AU - Michal,Michal, AU - Suster,Saul, AU - Sangueza,Martin, Y1 - 2014/04/14/ PY - 2013/11/25/received PY - 2014/01/10/revised PY - 2014/01/14/accepted PY - 2014/4/15/entrez PY - 2014/4/15/pubmed PY - 2014/9/17/medline KW - localized lymphedema KW - massive localized lymphedema KW - penile lymphedema KW - scrotal lymphedema KW - vulvar lymphedema SP - 320 EP - 6 JF - Journal of the American Academy of Dermatology JO - J. Am. Acad. Dermatol. VL - 71 IS - 2 N2 - BACKGROUND: Localized lymphedema is a nonneoplastic condition associated with obesity and predominantly involving the legs. This condition has distinctive clinical and histologic features and only rarely has been mentioned in the dermatologic literature. OBJECTIVE: We sought to evaluate the clinical and histopathologic features. METHODS: The clinicopathologic features in patients with localized lymphedema of the genital region were studied. RESULTS: We identified 18 patients with localized lymphedema clinically presenting as large polypoid or verrucous lesions. The patients were 5 men and 13 women with a mean age of 46.5 years. Twelve patients were obese at diagnosis. Thirteen patients presented with tumors involving the vulva, 4 patients with tumors in the penis and scrotum, and 1 patient with scrotal and pubic lesions. Histologically, all cases showed marked dermal edema along with dilated lymphatic spaces, fibroplasia, and verrucous epidermal changes (papillomatous and hyperplastic epidermis). LIMITATIONS: Only 18 cases were included in our study. CONCLUSIONS: This condition is an uncommon and recently described entity that could potentially be clinically and histologically misdiagnosed as a neoplasm; thus, it needs to be included in the differential diagnosis of polypoid and verrucous skin tumors with extensive dermal edema and fibroplasia. SN - 1097-6787 UR - https://www.unboundmedicine.com/medline/citation/24726400/Verrucous_localized_lymphedema_of_genital_areas:_clinicopathologic_report_of_18_cases_of_this_rare_entity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0190-9622(14)01045-7 DB - PRIME DP - Unbound Medicine ER -