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The Australian mulga snake (Pseudechis australis: Elapidae): report of a large case series of bites and review of current knowledge.
Toxicon 2014; 85:17-26T

Abstract

BACKGROUND

The mulga snake (Pseudechis australis) is the largest terrestrial venomous snake in Australia. It is capable of inflicting severe and occasionally fatal envenoming, but there have been few studies of P. australis bites.

OBJECTIVES

To highlight and reinforce the main features of P. australis envenoming and to provide a clearer picture of the epidemiology of bites from this species.

METHODS

Selected case records kept by the Toxinology Dept. (Women's and Children's Hospital, Adelaide, Australia) were reviewed retrospectively to determine definite P. australis bites.

INCLUSION CRITERIA

definite cases where the snake was identified by a competent person and/or lab specimens (bite site/urine) tested positive for "black snake" using CSL snake venom detection kit in a locality within the known range of P. australis, but without sympatry with other Pseudechis spp.

EXCLUSION CRITERIA

where the snake could not be clearly identified under criteria above. Epidemiological and clinical information was recorded and analysed for the definite cases.

RESULTS

A total of 27 cases were identified as definite P. australis bites; there were no fatalities. The median age was 35.5 years (IQR 51-23) and 80% of bites occurred in males. More bites occurred in the warmer months (Dec-March) and in those handling/interfering with snakes. Seven people were bitten whilst asleep at night. 21/27 patients developed systemic envenoming (based on signs, symptoms and laboratory results) and 17 cases received antivenom. Local bite site pain (18) and swelling (17) were common as were non-specific generalised symptoms such as nausea, vomiting and headache. Myotoxicity (11) and anticoagulant coagulopathy (10) occurred frequently; haemolysis was seen in fewer cases (3). Two patients developed local tissue injury around the bite site requiring further treatment.

CONCLUSIONS

This study confirms previous reports about P. australis bites with respect to high rates of envenoming, commonly associated with pain and swelling and systemic effects of rhabdomyolysis and anticoagulant coagulopathy. Systemic envenoming, even severe cases, responds well to antivenom therapy. Compared to other Australian snakes, a high proportion of bites occur in people asleep at night. Medically significant local tissue injury around the bite site may occur and may be associated with inappropriate first-aid, particularly the vascular occlusive type.

Authors+Show Affiliations

Toxinology Department, Women's & Children's Hospital, North Adelaide, SA 5006, Australia; Medical School, University of Bristol, Bristol BS8 1TH, UK.Toxinology Department, Women's & Children's Hospital, North Adelaide, SA 5006, Australia.Toxinology Department, Women's & Children's Hospital, North Adelaide, SA 5006, Australia. Electronic address: david.bates@adelaide.edu.au.Emergency Department, Royal Adelaide Hospital, North Tce, Adelaide, SA 5000, Australia.Toxinology Department, Women's & Children's Hospital, North Adelaide, SA 5006, Australia.

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

24726467

Citation

Razavi, Shahab, et al. "The Australian Mulga Snake (Pseudechis Australis: Elapidae): Report of a Large Case Series of Bites and Review of Current Knowledge." Toxicon : Official Journal of the International Society On Toxinology, vol. 85, 2014, pp. 17-26.
Razavi S, Weinstein SA, Bates DJ, et al. The Australian mulga snake (Pseudechis australis: Elapidae): report of a large case series of bites and review of current knowledge. Toxicon. 2014;85:17-26.
Razavi, S., Weinstein, S. A., Bates, D. J., Alfred, S., & White, J. (2014). The Australian mulga snake (Pseudechis australis: Elapidae): report of a large case series of bites and review of current knowledge. Toxicon : Official Journal of the International Society On Toxinology, 85, pp. 17-26. doi:10.1016/j.toxicon.2014.04.003.
Razavi S, et al. The Australian Mulga Snake (Pseudechis Australis: Elapidae): Report of a Large Case Series of Bites and Review of Current Knowledge. Toxicon. 2014;85:17-26. PubMed PMID: 24726467.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Australian mulga snake (Pseudechis australis: Elapidae): report of a large case series of bites and review of current knowledge. AU - Razavi,Shahab, AU - Weinstein,Scott A, AU - Bates,David J, AU - Alfred,Sam, AU - White,Julian, Y1 - 2014/04/13/ PY - 2013/11/20/received PY - 2014/03/28/revised PY - 2014/04/03/accepted PY - 2014/4/15/entrez PY - 2014/4/15/pubmed PY - 2015/1/16/medline KW - Clinical case KW - Envenoming KW - Local effects KW - Mulga snake KW - Myotoxicity KW - Pseudechis australis SP - 17 EP - 26 JF - Toxicon : official journal of the International Society on Toxinology JO - Toxicon VL - 85 N2 - BACKGROUND: The mulga snake (Pseudechis australis) is the largest terrestrial venomous snake in Australia. It is capable of inflicting severe and occasionally fatal envenoming, but there have been few studies of P. australis bites. OBJECTIVES: To highlight and reinforce the main features of P. australis envenoming and to provide a clearer picture of the epidemiology of bites from this species. METHODS: Selected case records kept by the Toxinology Dept. (Women's and Children's Hospital, Adelaide, Australia) were reviewed retrospectively to determine definite P. australis bites. INCLUSION CRITERIA: definite cases where the snake was identified by a competent person and/or lab specimens (bite site/urine) tested positive for "black snake" using CSL snake venom detection kit in a locality within the known range of P. australis, but without sympatry with other Pseudechis spp. EXCLUSION CRITERIA: where the snake could not be clearly identified under criteria above. Epidemiological and clinical information was recorded and analysed for the definite cases. RESULTS: A total of 27 cases were identified as definite P. australis bites; there were no fatalities. The median age was 35.5 years (IQR 51-23) and 80% of bites occurred in males. More bites occurred in the warmer months (Dec-March) and in those handling/interfering with snakes. Seven people were bitten whilst asleep at night. 21/27 patients developed systemic envenoming (based on signs, symptoms and laboratory results) and 17 cases received antivenom. Local bite site pain (18) and swelling (17) were common as were non-specific generalised symptoms such as nausea, vomiting and headache. Myotoxicity (11) and anticoagulant coagulopathy (10) occurred frequently; haemolysis was seen in fewer cases (3). Two patients developed local tissue injury around the bite site requiring further treatment. CONCLUSIONS: This study confirms previous reports about P. australis bites with respect to high rates of envenoming, commonly associated with pain and swelling and systemic effects of rhabdomyolysis and anticoagulant coagulopathy. Systemic envenoming, even severe cases, responds well to antivenom therapy. Compared to other Australian snakes, a high proportion of bites occur in people asleep at night. Medically significant local tissue injury around the bite site may occur and may be associated with inappropriate first-aid, particularly the vascular occlusive type. SN - 1879-3150 UR - https://www.unboundmedicine.com/medline/citation/24726467/The_Australian_mulga_snake__Pseudechis_australis:_Elapidae_:_report_of_a_large_case_series_of_bites_and_review_of_current_knowledge_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-0101(14)00104-4 DB - PRIME DP - Unbound Medicine ER -