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Face-to-face comparison of the predictive validity of two models of neuropathic pain in the rat: analgesic activity of pregabalin, tramadol and duloxetine.
Eur J Pharmacol. 2014 Jul 15; 735:17-25.EJ

Abstract

We compared the preclinical analgesic activity of three marketed drugs with different pharmacological properties, pregabalin, tramadol and duloxetine, described as effective against neuropathic pain in the clinic. These drugs were tested against evoked pain in two different neuropathic models in the rat, the Bennett (CCI) and the Chung (SNL) models. The selected endpoints were tactile allodynia, tactile hyperalgesia, heat hyperalgesia and cold allodynia. Although all three drugs displayed analgesic activity, the effects observed varied according to the behavioral evaluation. Pregabalin showed clear analgesic effects against cold allodynia and tactile hyperalgesia in both the CCI and Chung models. Tramadol was active against all four endpoints in the Chung model with similar effects in the CCI model, apart from tactile allodynia. Duloxetine inhibited tactile allodynia and heat hyperalgesia in both neuropathic pain models. It also displayed efficacy against tactile hyperalgesia in the CCI model and against cold allodynia in the Chung model. These data confirm that the CCI and the Chung models of neuropathic pain do not detect the activity of analgesics with the same sensitivity. Furthermore, the mode of stimulation (tactile or thermal) and the type of endpoint (allodynia or hyperalgesia) can further influence the observed efficacy of gold standards as well as novel compounds developed for treating neuropathic pain symptoms.

Authors+Show Affiliations

Porsolt S.A.S., Z.A. de Glatigné, 53940 Le Genest Saint Isle, France. Electronic address: clecudennec@porsolt.com.Porsolt S.A.S., Z.A. de Glatigné, 53940 Le Genest Saint Isle, France.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

24726848

Citation

Le Cudennec, Camille, and Vincent Castagné. "Face-to-face Comparison of the Predictive Validity of Two Models of Neuropathic Pain in the Rat: Analgesic Activity of Pregabalin, Tramadol and Duloxetine." European Journal of Pharmacology, vol. 735, 2014, pp. 17-25.
Le Cudennec C, Castagné V. Face-to-face comparison of the predictive validity of two models of neuropathic pain in the rat: analgesic activity of pregabalin, tramadol and duloxetine. Eur J Pharmacol. 2014;735:17-25.
Le Cudennec, C., & Castagné, V. (2014). Face-to-face comparison of the predictive validity of two models of neuropathic pain in the rat: analgesic activity of pregabalin, tramadol and duloxetine. European Journal of Pharmacology, 735, 17-25. https://doi.org/10.1016/j.ejphar.2014.04.003
Le Cudennec C, Castagné V. Face-to-face Comparison of the Predictive Validity of Two Models of Neuropathic Pain in the Rat: Analgesic Activity of Pregabalin, Tramadol and Duloxetine. Eur J Pharmacol. 2014 Jul 15;735:17-25. PubMed PMID: 24726848.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Face-to-face comparison of the predictive validity of two models of neuropathic pain in the rat: analgesic activity of pregabalin, tramadol and duloxetine. AU - Le Cudennec,Camille, AU - Castagné,Vincent, Y1 - 2014/04/12/ PY - 2013/12/26/received PY - 2014/04/02/revised PY - 2014/04/03/accepted PY - 2014/4/15/entrez PY - 2014/4/15/pubmed PY - 2015/1/23/medline KW - Analgesics KW - Anticonvulsants KW - Antidepressants KW - Neuropathic pain KW - Rodents SP - 17 EP - 25 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 735 N2 - We compared the preclinical analgesic activity of three marketed drugs with different pharmacological properties, pregabalin, tramadol and duloxetine, described as effective against neuropathic pain in the clinic. These drugs were tested against evoked pain in two different neuropathic models in the rat, the Bennett (CCI) and the Chung (SNL) models. The selected endpoints were tactile allodynia, tactile hyperalgesia, heat hyperalgesia and cold allodynia. Although all three drugs displayed analgesic activity, the effects observed varied according to the behavioral evaluation. Pregabalin showed clear analgesic effects against cold allodynia and tactile hyperalgesia in both the CCI and Chung models. Tramadol was active against all four endpoints in the Chung model with similar effects in the CCI model, apart from tactile allodynia. Duloxetine inhibited tactile allodynia and heat hyperalgesia in both neuropathic pain models. It also displayed efficacy against tactile hyperalgesia in the CCI model and against cold allodynia in the Chung model. These data confirm that the CCI and the Chung models of neuropathic pain do not detect the activity of analgesics with the same sensitivity. Furthermore, the mode of stimulation (tactile or thermal) and the type of endpoint (allodynia or hyperalgesia) can further influence the observed efficacy of gold standards as well as novel compounds developed for treating neuropathic pain symptoms. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/24726848/Face_to_face_comparison_of_the_predictive_validity_of_two_models_of_neuropathic_pain_in_the_rat:_analgesic_activity_of_pregabalin_tramadol_and_duloxetine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(14)00269-6 DB - PRIME DP - Unbound Medicine ER -