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Resistance exercise: a strategy to attenuate inflammation and protein-energy wasting in hemodialysis patients?
Int Urol Nephrol. 2014 Aug; 46(8):1655-62.IU

Abstract

PURPOSE

Patients undergoing hemodialysis (HD) present persistent inflammation and protein-energy wasting (PEW), which contributes to high rates of mortality. This study aimed to assess the effects of a resistance exercise training program (RETP) on inflammation and PEW in HD patients.

METHODS

Thirty-seven patients (56.7 % men, 45.9 ± 14.1 years, 23.5 ± 3.9 kg/m(2)) performed 6 months of intradialytic RETP. Plasma adhesion molecules levels (ICAM-1 and VCAM-1) were measured using the enzyme immunometric assay, and interleukin-6 (IL-6), C-reactive protein, and tumor necrosis factor-alpha by ELISA. Anthropometric, physical capacity, and PEW (simultaneously presence of: BMI <23 kg/m(2), serum albumin <3.8 g/dL, and reduced arm muscle area) were analyzed.

RESULTS

There was a reduction of ICAM-1 [(1,934.1 pg/mL (1,031.8-2,875.0) vs. 1,571.1 pg/mL (447.1-2,985.5), p < 0.05], VCAM-1 [5,259.51 pg/mL (3,967.4-6,682.4) vs. 3,062.11 pg/mL (2,034.0-5,034.4), p < 0.05], and CRP levels (2.3 ± 0.9 to 1.6 ± 0.6 pg/mL, p < 0.001) after 6 months of RETP. Body composition improved, albumin increased (3.7 ± 0.3 to 3.9 ± 0.2, p < 0.05), and the number of patients presenting PEW was decreased (p = 0.005).

CONCLUSIONS

Resistance exercise program for 6 months seems to be effective in reducing inflammation and PEW of HD patients. The universal trial number of this study is U1111-1139-1326.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Moraes C
Graduate Program in Cardiovascular Sciences, Fluminense Federal University (UFF), Niterói, RJ, Brazil, moraesmjc@gmail.com.
Marinho SM
No affiliation info available
da Nobrega AC
No affiliation info available
de Oliveira Bessa B
No affiliation info available
Jacobson LV
No affiliation info available
Stockler-Pinto MB
No affiliation info available
da Silva WS
No affiliation info available
Mafra D
No affiliation info available

MeSH

AdultBiomarkersC-Reactive ProteinExercise TestExercise ToleranceFemaleHumansInflammationInterleukin-6Longitudinal StudiesMaleMiddle AgedMuscle StrengthMuscle, SkeletalNutritional StatusProtein-Energy MalnutritionRenal DialysisRenal Insufficiency, ChronicResistance TrainingSerum AlbuminTumor Necrosis Factor-alpha

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

24729104

Citation

Moraes, Cristiane, et al. "Resistance Exercise: a Strategy to Attenuate Inflammation and Protein-energy Wasting in Hemodialysis Patients?" International Urology and Nephrology, vol. 46, no. 8, 2014, pp. 1655-62.
Moraes C, Marinho SM, da Nobrega AC, et al. Resistance exercise: a strategy to attenuate inflammation and protein-energy wasting in hemodialysis patients? Int Urol Nephrol. 2014;46(8):1655-62.
Moraes, C., Marinho, S. M., da Nobrega, A. C., de Oliveira Bessa, B., Jacobson, L. V., Stockler-Pinto, M. B., da Silva, W. S., & Mafra, D. (2014). Resistance exercise: a strategy to attenuate inflammation and protein-energy wasting in hemodialysis patients? International Urology and Nephrology, 46(8), 1655-62. https://doi.org/10.1007/s11255-014-0712-3
Moraes C, et al. Resistance Exercise: a Strategy to Attenuate Inflammation and Protein-energy Wasting in Hemodialysis Patients. Int Urol Nephrol. 2014;46(8):1655-62. PubMed PMID: 24729104.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Resistance exercise: a strategy to attenuate inflammation and protein-energy wasting in hemodialysis patients? AU - Moraes,Cristiane, AU - Marinho,Sandra Mara, AU - da Nobrega,Antonio Claudio, AU - de Oliveira Bessa,Bruno, AU - Jacobson,Ludmilla Viana, AU - Stockler-Pinto,Milena Barcza, AU - da Silva,Wellington Seguins, AU - Mafra,Denise, Y1 - 2014/04/13/ PY - 2014/02/18/received PY - 2014/03/31/accepted PY - 2014/4/15/entrez PY - 2014/4/15/pubmed PY - 2015/5/12/medline SP - 1655 EP - 62 JF - International urology and nephrology JO - Int Urol Nephrol VL - 46 IS - 8 N2 - PURPOSE: Patients undergoing hemodialysis (HD) present persistent inflammation and protein-energy wasting (PEW), which contributes to high rates of mortality. This study aimed to assess the effects of a resistance exercise training program (RETP) on inflammation and PEW in HD patients. METHODS: Thirty-seven patients (56.7 % men, 45.9 ± 14.1 years, 23.5 ± 3.9 kg/m(2)) performed 6 months of intradialytic RETP. Plasma adhesion molecules levels (ICAM-1 and VCAM-1) were measured using the enzyme immunometric assay, and interleukin-6 (IL-6), C-reactive protein, and tumor necrosis factor-alpha by ELISA. Anthropometric, physical capacity, and PEW (simultaneously presence of: BMI <23 kg/m(2), serum albumin <3.8 g/dL, and reduced arm muscle area) were analyzed. RESULTS: There was a reduction of ICAM-1 [(1,934.1 pg/mL (1,031.8-2,875.0) vs. 1,571.1 pg/mL (447.1-2,985.5), p < 0.05], VCAM-1 [5,259.51 pg/mL (3,967.4-6,682.4) vs. 3,062.11 pg/mL (2,034.0-5,034.4), p < 0.05], and CRP levels (2.3 ± 0.9 to 1.6 ± 0.6 pg/mL, p < 0.001) after 6 months of RETP. Body composition improved, albumin increased (3.7 ± 0.3 to 3.9 ± 0.2, p < 0.05), and the number of patients presenting PEW was decreased (p = 0.005). CONCLUSIONS: Resistance exercise program for 6 months seems to be effective in reducing inflammation and PEW of HD patients. The universal trial number of this study is U1111-1139-1326. SN - 1573-2584 UR - https://www.unboundmedicine.com/medline/citation/24729104/Resistance_exercise:_a_strategy_to_attenuate_inflammation_and_protein_energy_wasting_in_hemodialysis_patients DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓14 ↑30]

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