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Alcohol consumption and risk of incident rheumatoid arthritis in women: a prospective study.
Arthritis Rheumatol 2014; 66(8):1998-2005AR

Abstract

OBJECTIVE

To evaluate the association of alcohol consumption with the risk of rheumatoid arthritis (RA) in 2 large prospective cohorts, the Nurses' Health Study (NHS) and NHSII.

METHODS

The NHS was established in 1976 and enrolled 121,701 female registered nurses in the US. The NHSII began in 1989, enrolling 116,430 female nurses. Lifestyle and environmental exposures were collected through biennial questionnaires. Alcohol consumption was assessed with a food frequency questionnaire, which was completed every 4 years. Incident RA cases were identified using a connective tissue disease screening questionnaire and a medical record review. Separate Cox proportional hazards models were used to estimate hazard ratios (HRs) after adjusting for potential confounders in the NHS and NHSII. The pooled HR from 2 cohorts was estimated using a DerSimonian and Laird random-effects model.

RESULTS

Among 1.90 million person-years from 1980 to 2008, 580 incident cases of RA were diagnosed in the NHS cohort, and among 1.78 million person-years from 1989 to 2009, 323 incident cases of RA were diagnosed in the NHSII cohort. Compared to no use, the pooled multivariable adjusted HR for alcohol use of 5.0-9.9 gm/day was 0.78 (95% confidence interval [95% CI] 0.61-1.00). For seropositive RA cases, the association appeared stronger (HR 0.69 [95% CI 0.50-0.95]). In addition, women who drank beer 2-4 times a week had a 31% decreased risk compared to women who never drank beer.

CONCLUSION

We found a modest association between long-term moderate alcohol drinking and reduced risk of RA. Future studies are needed to confirm our findings in other populations.

Authors+Show Affiliations

Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

24729427

Citation

Lu, Bing, et al. "Alcohol Consumption and Risk of Incident Rheumatoid Arthritis in Women: a Prospective Study." Arthritis & Rheumatology (Hoboken, N.J.), vol. 66, no. 8, 2014, pp. 1998-2005.
Lu B, Solomon DH, Costenbader KH, et al. Alcohol consumption and risk of incident rheumatoid arthritis in women: a prospective study. Arthritis & rheumatology (Hoboken, N.J.). 2014;66(8):1998-2005.
Lu, B., Solomon, D. H., Costenbader, K. H., & Karlson, E. W. (2014). Alcohol consumption and risk of incident rheumatoid arthritis in women: a prospective study. Arthritis & Rheumatology (Hoboken, N.J.), 66(8), pp. 1998-2005. doi:10.1002/art.38634.
Lu B, et al. Alcohol Consumption and Risk of Incident Rheumatoid Arthritis in Women: a Prospective Study. Arthritis & rheumatology (Hoboken, N.J.). 2014;66(8):1998-2005. PubMed PMID: 24729427.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol consumption and risk of incident rheumatoid arthritis in women: a prospective study. AU - Lu,Bing, AU - Solomon,Daniel H, AU - Costenbader,Karen H, AU - Karlson,Elizabeth W, PY - 2013/07/19/received PY - 2014/03/13/accepted PY - 2014/4/15/entrez PY - 2014/4/15/pubmed PY - 2014/9/23/medline SP - 1998 EP - 2005 JF - Arthritis & rheumatology (Hoboken, N.J.) VL - 66 IS - 8 N2 - OBJECTIVE: To evaluate the association of alcohol consumption with the risk of rheumatoid arthritis (RA) in 2 large prospective cohorts, the Nurses' Health Study (NHS) and NHSII. METHODS: The NHS was established in 1976 and enrolled 121,701 female registered nurses in the US. The NHSII began in 1989, enrolling 116,430 female nurses. Lifestyle and environmental exposures were collected through biennial questionnaires. Alcohol consumption was assessed with a food frequency questionnaire, which was completed every 4 years. Incident RA cases were identified using a connective tissue disease screening questionnaire and a medical record review. Separate Cox proportional hazards models were used to estimate hazard ratios (HRs) after adjusting for potential confounders in the NHS and NHSII. The pooled HR from 2 cohorts was estimated using a DerSimonian and Laird random-effects model. RESULTS: Among 1.90 million person-years from 1980 to 2008, 580 incident cases of RA were diagnosed in the NHS cohort, and among 1.78 million person-years from 1989 to 2009, 323 incident cases of RA were diagnosed in the NHSII cohort. Compared to no use, the pooled multivariable adjusted HR for alcohol use of 5.0-9.9 gm/day was 0.78 (95% confidence interval [95% CI] 0.61-1.00). For seropositive RA cases, the association appeared stronger (HR 0.69 [95% CI 0.50-0.95]). In addition, women who drank beer 2-4 times a week had a 31% decreased risk compared to women who never drank beer. CONCLUSION: We found a modest association between long-term moderate alcohol drinking and reduced risk of RA. Future studies are needed to confirm our findings in other populations. SN - 2326-5205 UR - https://www.unboundmedicine.com/medline/citation/24729427/Alcohol_consumption_and_risk_of_incident_rheumatoid_arthritis_in_women:_a_prospective_study_ L2 - https://doi.org/10.1002/art.38634 DB - PRIME DP - Unbound Medicine ER -