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The effect of mycotoxin deoxynivalenol on haematological and biochemical indicators and histopathological changes in rainbow trout (Oncorhynchus mykiss).
Biomed Res Int. 2014; 2014:310680.BR

Abstract

Deoxynivalenol (DON), produced by the Fusarium genus, is a major contaminant of cereal grains used in the production of fish feed. The effect of mycotoxin deoxynivalenol on rainbow trout (Oncorhynchus mykiss) was studied using a commercial feed with the addition of DON in a dose of 2 mg/kg feed. The fish (n=40) were exposed to the mycotoxin for 23 days. The trout were divided into two groups, control and experimental groups. Control groups were fed a commercial feed naturally contaminated with a low concentration of DON (225 μg/kg feed); experimental groups were fed a commercial feed with the addition of DON (1964 μg/kg feed). Plasma biochemical and haematological indices, biometric parameters, and histopathological changes were assessed at the end of the experiment. The experimental groups showed significantly lower values in MCH (P<0.05). In biochemical indices, after 23-day exposure, a significant decrease in glucose, cholesterol (P<0.05), and ammonia (P<0.01) was recorded in the experimental group compared to the control group. Our assessment showed no significant changes in biometric parameters. The histopathological examination revealed disorders in the caudal kidney of the exposed fish. The obtained data show the sensitivity of rainbow trout (O. mykiss) to deoxynivalenol.

Authors+Show Affiliations

Department of Veterinary Public Health and Welfare, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Palackeho tr. 1/3, 612 42 Brno, Czech Republic.Department of Veterinary Public Health and Welfare, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Palackeho tr. 1/3, 612 42 Brno, Czech Republic.Department of Veterinary Public Health and Welfare, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Palackeho tr. 1/3, 612 42 Brno, Czech Republic.Department of Pharmaceutics and Biopharmacy, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackeho tr. 1/3, 612 42 Brno, Czech Republic.Department of Pathological Morphology and Parasitology, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences Brno, Palackeho tr. 1/3, 612 42 Brno, Czech Republic.Department of Veterinary Public Health and Welfare, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Palackeho tr. 1/3, 612 42 Brno, Czech Republic.Department of Veterinary Public Health and Welfare, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Palackeho tr. 1/3, 612 42 Brno, Czech Republic.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24729967

Citation

Matejova, Iveta, et al. "The Effect of Mycotoxin Deoxynivalenol On Haematological and Biochemical Indicators and Histopathological Changes in Rainbow Trout (Oncorhynchus Mykiss)." BioMed Research International, vol. 2014, 2014, p. 310680.
Matejova I, Modra H, Blahova J, et al. The effect of mycotoxin deoxynivalenol on haematological and biochemical indicators and histopathological changes in rainbow trout (Oncorhynchus mykiss). Biomed Res Int. 2014;2014:310680.
Matejova, I., Modra, H., Blahova, J., Franc, A., Fictum, P., Sevcikova, M., & Svobodova, Z. (2014). The effect of mycotoxin deoxynivalenol on haematological and biochemical indicators and histopathological changes in rainbow trout (Oncorhynchus mykiss). BioMed Research International, 2014, 310680. https://doi.org/10.1155/2014/310680
Matejova I, et al. The Effect of Mycotoxin Deoxynivalenol On Haematological and Biochemical Indicators and Histopathological Changes in Rainbow Trout (Oncorhynchus Mykiss). Biomed Res Int. 2014;2014:310680. PubMed PMID: 24729967.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of mycotoxin deoxynivalenol on haematological and biochemical indicators and histopathological changes in rainbow trout (Oncorhynchus mykiss). AU - Matejova,Iveta, AU - Modra,Helena, AU - Blahova,Jana, AU - Franc,Ales, AU - Fictum,Petr, AU - Sevcikova,Marie, AU - Svobodova,Zdenka, Y1 - 2014/03/04/ PY - 2013/12/09/received PY - 2014/01/27/revised PY - 2014/01/27/accepted PY - 2014/4/15/entrez PY - 2014/4/15/pubmed PY - 2015/1/8/medline SP - 310680 EP - 310680 JF - BioMed research international JO - Biomed Res Int VL - 2014 N2 - Deoxynivalenol (DON), produced by the Fusarium genus, is a major contaminant of cereal grains used in the production of fish feed. The effect of mycotoxin deoxynivalenol on rainbow trout (Oncorhynchus mykiss) was studied using a commercial feed with the addition of DON in a dose of 2 mg/kg feed. The fish (n=40) were exposed to the mycotoxin for 23 days. The trout were divided into two groups, control and experimental groups. Control groups were fed a commercial feed naturally contaminated with a low concentration of DON (225 μg/kg feed); experimental groups were fed a commercial feed with the addition of DON (1964 μg/kg feed). Plasma biochemical and haematological indices, biometric parameters, and histopathological changes were assessed at the end of the experiment. The experimental groups showed significantly lower values in MCH (P<0.05). In biochemical indices, after 23-day exposure, a significant decrease in glucose, cholesterol (P<0.05), and ammonia (P<0.01) was recorded in the experimental group compared to the control group. Our assessment showed no significant changes in biometric parameters. The histopathological examination revealed disorders in the caudal kidney of the exposed fish. The obtained data show the sensitivity of rainbow trout (O. mykiss) to deoxynivalenol. SN - 2314-6141 UR - https://www.unboundmedicine.com/medline/citation/24729967/The_effect_of_mycotoxin_deoxynivalenol_on_haematological_and_biochemical_indicators_and_histopathological_changes_in_rainbow_trout__Oncorhynchus_mykiss__ L2 - https://doi.org/10.1155/2014/310680 DB - PRIME DP - Unbound Medicine ER -