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Serum 25-hydroxyvitamin D and incidence of diabetes in elderly people: the PRO.V.A. study.
J Clin Endocrinol Metab. 2014 Jul; 99(7):2351-8.JC

Abstract

CONTEXT

Increasing research has shown that low levels of serum 25-hydroxyvitamin (25OHD) predict the onset of diabetes, but no research is available on this issue in elderly people.

OBJECTIVE

Our objective was to examine whether low serum levels of 25OHD are associated with a higher risk of incident type 2 diabetes over a lengthy follow-up in a representative group of elderly people.

DESIGN AND SETTING

This was a population-based cohort study as part of the Progetto Veneto Anziani (Pro.V.A.) Study over a follow-up of 4.4 years in the general community.

PARTICIPANTS

PARTICIPANTS included 2227 participants (1728 with follow-up visits and 499 died during the follow-up) over 65 years of age without diabetes at baseline, of 2352 initially included.

MAIN OUTCOME MEASURE

The main outcome measure was incident diabetes.

RESULTS

There were no baseline differences in known factors for the onset of diabetes (body mass index, waist circumference, total cholesterol, renal function, and hemoglobin A1c levels) between the groups with different serum 25OHD levels (≤ 25, 25-50, 50-75, and ≥ 75 nmol/L). Over a 4.4-year follow-up, 291 individuals developed diabetes, with an incidence of 28 events per 1000 person-years. No significant difference in the incidence of diabetes emerged between the baseline 25OHD groups. Cox's regression analysis, adjusted for potential confounders, revealed no relationship between low vitamin D levels and incident diabetes during the follow-up (hazard ratio [HR] = 1.05, 95% confidence interval [CI] = 0.76-1.45, P = .77; HR = 1.44, 95% CI = 0.95-1.98, P = .12; and HR = 1.37, 95% CI = 0.87-2.16, P = .17 for those with 25OHD ≤25, 25-50, and 50-75 nmol/L, respectively).

CONCLUSION

Baseline serum concentrations of 25OHD were not associated with the incidence of diabetes in community-dwelling elderly people over a follow-up of 4.4 years.

Authors+Show Affiliations

Department of Medicine (N.V., G.S., M.D.R., F.B., E.D.T., E.M.), Geriatrics Division; Department of Medical and Surgical Sciences (S.Z., E.M.); and Department of Cardiac, Thoracic, and Vascular Sciences (E.P.), Unit of Biostatistics, Epidemiology, and Public Health, University of Padova, 35128 Padova, Italy; National Research Council (S.Z., G.C., E.M.), Aging Branch, Institute of Neuroscience, 35128 Padova, Italy; Azienda Unità Locale Socio Sanitaria 16, 35127 Padova (M.-C.C.), Padova, Italy; and Internal Medicine Division (G.B.), Azienda Ospedaliera, 35128 Padova, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24731010

Citation

Veronese, Nicola, et al. "Serum 25-hydroxyvitamin D and Incidence of Diabetes in Elderly People: the PRO.V.A. Study." The Journal of Clinical Endocrinology and Metabolism, vol. 99, no. 7, 2014, pp. 2351-8.
Veronese N, Sergi G, De Rui M, et al. Serum 25-hydroxyvitamin D and incidence of diabetes in elderly people: the PRO.V.A. study. J Clin Endocrinol Metab. 2014;99(7):2351-8.
Veronese, N., Sergi, G., De Rui, M., Bolzetta, F., Toffanello, E. D., Zambon, S., Corti, M. C., Sartori, L., Musacchio, E., Baggio, G., Crepaldi, G., Perissinotto, E., & Manzato, E. (2014). Serum 25-hydroxyvitamin D and incidence of diabetes in elderly people: the PRO.V.A. study. The Journal of Clinical Endocrinology and Metabolism, 99(7), 2351-8. https://doi.org/10.1210/jc.2013-3883
Veronese N, et al. Serum 25-hydroxyvitamin D and Incidence of Diabetes in Elderly People: the PRO.V.A. Study. J Clin Endocrinol Metab. 2014;99(7):2351-8. PubMed PMID: 24731010.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum 25-hydroxyvitamin D and incidence of diabetes in elderly people: the PRO.V.A. study. AU - Veronese,Nicola, AU - Sergi,Giuseppe, AU - De Rui,Marina, AU - Bolzetta,Francesco, AU - Toffanello,Elena Debora, AU - Zambon,Sabina, AU - Corti,Maria-Chiara, AU - Sartori,Leonardo, AU - Musacchio,Estella, AU - Baggio,Giovannella, AU - Crepaldi,Gaetano, AU - Perissinotto,Egle, AU - Manzato,Enzo, Y1 - 2014/04/14/ PY - 2014/4/16/entrez PY - 2014/4/16/pubmed PY - 2014/9/30/medline SP - 2351 EP - 8 JF - The Journal of clinical endocrinology and metabolism JO - J. Clin. Endocrinol. Metab. VL - 99 IS - 7 N2 - CONTEXT: Increasing research has shown that low levels of serum 25-hydroxyvitamin (25OHD) predict the onset of diabetes, but no research is available on this issue in elderly people. OBJECTIVE: Our objective was to examine whether low serum levels of 25OHD are associated with a higher risk of incident type 2 diabetes over a lengthy follow-up in a representative group of elderly people. DESIGN AND SETTING: This was a population-based cohort study as part of the Progetto Veneto Anziani (Pro.V.A.) Study over a follow-up of 4.4 years in the general community. PARTICIPANTS: PARTICIPANTS included 2227 participants (1728 with follow-up visits and 499 died during the follow-up) over 65 years of age without diabetes at baseline, of 2352 initially included. MAIN OUTCOME MEASURE: The main outcome measure was incident diabetes. RESULTS: There were no baseline differences in known factors for the onset of diabetes (body mass index, waist circumference, total cholesterol, renal function, and hemoglobin A1c levels) between the groups with different serum 25OHD levels (≤ 25, 25-50, 50-75, and ≥ 75 nmol/L). Over a 4.4-year follow-up, 291 individuals developed diabetes, with an incidence of 28 events per 1000 person-years. No significant difference in the incidence of diabetes emerged between the baseline 25OHD groups. Cox's regression analysis, adjusted for potential confounders, revealed no relationship between low vitamin D levels and incident diabetes during the follow-up (hazard ratio [HR] = 1.05, 95% confidence interval [CI] = 0.76-1.45, P = .77; HR = 1.44, 95% CI = 0.95-1.98, P = .12; and HR = 1.37, 95% CI = 0.87-2.16, P = .17 for those with 25OHD ≤25, 25-50, and 50-75 nmol/L, respectively). CONCLUSION: Baseline serum concentrations of 25OHD were not associated with the incidence of diabetes in community-dwelling elderly people over a follow-up of 4.4 years. SN - 1945-7197 UR - https://www.unboundmedicine.com/medline/citation/24731010/Serum_25_hydroxyvitamin_D_and_incidence_of_diabetes_in_elderly_people:_the_PRO_V_A__study_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2013-3883 DB - PRIME DP - Unbound Medicine ER -