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Astragaloside IV attenuates allergic inflammation by regulation Th1/Th2 cytokine and enhancement CD4(+)CD25(+)Foxp3 T cells in ovalbumin-induced asthma.
Immunobiology. 2014 Jul; 219(7):565-71.I

Abstract

Astragaloside IV is the chief ingredient of Radix Astragali, which has been used in the Traditional Chinese Medicine as a major component of many polyherbal formulations for the repair and regeneration of injured organ and tissues. We tested the anti-asthmatic effects of AST IV and the possible mechanisms. BALB/c mice that were sensitized and challenged to ovalbumin (OVA) were treated with AST IV (40mg/kg and 20mg/kg) 1h before they were challenged with OVA. Our study demonstrated that AST IV inhibited OVA-induced increases in eosinophil count; interleukin (IL)-4 level were recovered in bronchoalveolar lavage fluid increased IFN-γ and IL-10 levels in bronchoalveolar lavage fluid. Histological studies demonstrated that AST IV substantially inhibited OVA-induced eosinophilia in lung tissue. Flow cytometry studies demonstrated that AST IV substantially increased CD4(+)CD25(+)Foxp3 T cells (Treg). Furthermore quantitative real-time (qPCR) studies demonstrated that AST IV substantially enhanced Foxp3 mRNA expression in lung tissue. These findings suggest that AST IV may effectively ameliorate the progression of airway inflammation and could be used as a therapy for patients with allergic inflammation.

Authors+Show Affiliations

School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou 213164, PR China.School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou 213164, PR China.School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou 213164, PR China.School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou 213164, PR China. Electronic address: drugs@vip.sina.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24731407

Citation

Huang, Xianfeng, et al. "Astragaloside IV Attenuates Allergic Inflammation By Regulation Th1/Th2 Cytokine and Enhancement CD4(+)CD25(+)Foxp3 T Cells in Ovalbumin-induced Asthma." Immunobiology, vol. 219, no. 7, 2014, pp. 565-71.
Huang X, Tang L, Wang F, et al. Astragaloside IV attenuates allergic inflammation by regulation Th1/Th2 cytokine and enhancement CD4(+)CD25(+)Foxp3 T cells in ovalbumin-induced asthma. Immunobiology. 2014;219(7):565-71.
Huang, X., Tang, L., Wang, F., & Song, G. (2014). Astragaloside IV attenuates allergic inflammation by regulation Th1/Th2 cytokine and enhancement CD4(+)CD25(+)Foxp3 T cells in ovalbumin-induced asthma. Immunobiology, 219(7), 565-71. https://doi.org/10.1016/j.imbio.2014.03.005
Huang X, et al. Astragaloside IV Attenuates Allergic Inflammation By Regulation Th1/Th2 Cytokine and Enhancement CD4(+)CD25(+)Foxp3 T Cells in Ovalbumin-induced Asthma. Immunobiology. 2014;219(7):565-71. PubMed PMID: 24731407.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Astragaloside IV attenuates allergic inflammation by regulation Th1/Th2 cytokine and enhancement CD4(+)CD25(+)Foxp3 T cells in ovalbumin-induced asthma. AU - Huang,Xianfeng, AU - Tang,Long, AU - Wang,Fan, AU - Song,Guoqiang, Y1 - 2014/03/20/ PY - 2013/01/09/received PY - 2013/07/10/revised PY - 2014/03/12/accepted PY - 2014/4/16/entrez PY - 2014/4/16/pubmed PY - 2015/2/7/medline KW - Asthma KW - Astragaloside IV KW - Th1/Th2 KW - Treg SP - 565 EP - 71 JF - Immunobiology JO - Immunobiology VL - 219 IS - 7 N2 - Astragaloside IV is the chief ingredient of Radix Astragali, which has been used in the Traditional Chinese Medicine as a major component of many polyherbal formulations for the repair and regeneration of injured organ and tissues. We tested the anti-asthmatic effects of AST IV and the possible mechanisms. BALB/c mice that were sensitized and challenged to ovalbumin (OVA) were treated with AST IV (40mg/kg and 20mg/kg) 1h before they were challenged with OVA. Our study demonstrated that AST IV inhibited OVA-induced increases in eosinophil count; interleukin (IL)-4 level were recovered in bronchoalveolar lavage fluid increased IFN-γ and IL-10 levels in bronchoalveolar lavage fluid. Histological studies demonstrated that AST IV substantially inhibited OVA-induced eosinophilia in lung tissue. Flow cytometry studies demonstrated that AST IV substantially increased CD4(+)CD25(+)Foxp3 T cells (Treg). Furthermore quantitative real-time (qPCR) studies demonstrated that AST IV substantially enhanced Foxp3 mRNA expression in lung tissue. These findings suggest that AST IV may effectively ameliorate the progression of airway inflammation and could be used as a therapy for patients with allergic inflammation. SN - 1878-3279 UR - https://www.unboundmedicine.com/medline/citation/24731407/Astragaloside_IV_attenuates_allergic_inflammation_by_regulation_Th1/Th2_cytokine_and_enhancement_CD4_+_CD25_+_Foxp3_T_cells_in_ovalbumin_induced_asthma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0171-2985(14)00053-9 DB - PRIME DP - Unbound Medicine ER -