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Fish intake and ovarian cancer risk: a meta-analysis of 15 case-control and cohort studies.

Abstract

BACKGROUND

Previous epidemiological studies have shown that fish consumption may modify the risk of ovarian cancer. However, these studies yielded controversial results. The present meta-analysis was undertaken to evaluate the relationship between fish intake and ovarian cancer risk.

METHODS

A literature search was carried out using Pubmed, Embase, and Cochrane Library Central database for all relevant studies up to August 2013. We pooled the relative risks (RR) from individual studies using fixed-effect or random-effect model, and carried out heterogeneity and publication bias analyses.

RESULTS

A total of 15 (ten case-control, and five cohort) studies were included in the present meta-analysis, representing data for 889,033 female subjects and 6,087 ovarian cancer cases. We found that total fish intake was not significantly associated with the risk of ovarian cancer among cohort studies (RR = 1.04 95% CI [0.89, 1.22]) as well as case-control studies (RR = 0.90, 95% CI [0.73,1.12]). There was no evidence of publication bias as suggested by Begg's test (P = 0.55) and Egger's test(P = 0.29).

CONCLUSIONS

The present meta-analysis showed that total fish consumption was not significantly associated with the risk of ovarian cancer. Further analysis on different fish species and food preparation methods should be conducted in future studies.

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  • Authors+Show Affiliations

    ,

    Department of Gynecological Oncology, First Hospital of Jilin University, Changchun, China.

    ,

    Department of Gastroenterology, China-Japan Union Hospital of Jilin University, Changchun, China.

    ,

    Department of Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.

    Department of Gynecological Oncology, First Hospital of Jilin University, Changchun, China.

    Source

    PloS one 9:4 2014 pg e94601

    MeSH

    Animals
    Diet
    Epidemiologic Studies
    Female
    Fish Products
    Fishes
    Geography
    Humans
    Observational Studies as Topic
    Odds Ratio
    Ovarian Neoplasms
    Risk Assessment

    Pub Type(s)

    Journal Article
    Meta-Analysis

    Language

    eng

    PubMed ID

    24732053

    Citation

    Jiang, Pei-yue, et al. "Fish Intake and Ovarian Cancer Risk: a Meta-analysis of 15 Case-control and Cohort Studies." PloS One, vol. 9, no. 4, 2014, pp. e94601.
    Jiang PY, Jiang ZB, Shen KX, et al. Fish intake and ovarian cancer risk: a meta-analysis of 15 case-control and cohort studies. PLoS ONE. 2014;9(4):e94601.
    Jiang, P. Y., Jiang, Z. B., Shen, K. X., & Yue, Y. (2014). Fish intake and ovarian cancer risk: a meta-analysis of 15 case-control and cohort studies. PloS One, 9(4), pp. e94601. doi:10.1371/journal.pone.0094601.
    Jiang PY, et al. Fish Intake and Ovarian Cancer Risk: a Meta-analysis of 15 Case-control and Cohort Studies. PLoS ONE. 2014;9(4):e94601. PubMed PMID: 24732053.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Fish intake and ovarian cancer risk: a meta-analysis of 15 case-control and cohort studies. AU - Jiang,Pei-yue, AU - Jiang,Zhong-bo, AU - Shen,Ke-xin, AU - Yue,Ying, Y1 - 2014/04/14/ PY - 2013/12/18/received PY - 2014/03/18/accepted PY - 2014/4/16/entrez PY - 2014/4/16/pubmed PY - 2015/1/20/medline SP - e94601 EP - e94601 JF - PloS one JO - PLoS ONE VL - 9 IS - 4 N2 - BACKGROUND: Previous epidemiological studies have shown that fish consumption may modify the risk of ovarian cancer. However, these studies yielded controversial results. The present meta-analysis was undertaken to evaluate the relationship between fish intake and ovarian cancer risk. METHODS: A literature search was carried out using Pubmed, Embase, and Cochrane Library Central database for all relevant studies up to August 2013. We pooled the relative risks (RR) from individual studies using fixed-effect or random-effect model, and carried out heterogeneity and publication bias analyses. RESULTS: A total of 15 (ten case-control, and five cohort) studies were included in the present meta-analysis, representing data for 889,033 female subjects and 6,087 ovarian cancer cases. We found that total fish intake was not significantly associated with the risk of ovarian cancer among cohort studies (RR = 1.04 95% CI [0.89, 1.22]) as well as case-control studies (RR = 0.90, 95% CI [0.73,1.12]). There was no evidence of publication bias as suggested by Begg's test (P = 0.55) and Egger's test(P = 0.29). CONCLUSIONS: The present meta-analysis showed that total fish consumption was not significantly associated with the risk of ovarian cancer. Further analysis on different fish species and food preparation methods should be conducted in future studies. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/24732053/Fish_intake_and_ovarian_cancer_risk:_a_meta_analysis_of_15_case_control_and_cohort_studies_ L2 - http://dx.plos.org/10.1371/journal.pone.0094601 DB - PRIME DP - Unbound Medicine ER -