Tags

Type your tag names separated by a space and hit enter

Role of methylglyoxal in Alzheimer's disease.
Biomed Res Int 2014; 2014:238485BR

Abstract

Alzheimer's disease is the most common and lethal neurodegenerative disorder. The major hallmarks of Alzheimer's disease are extracellular aggregation of amyloid β peptides and, the presence of intracellular neurofibrillary tangles formed by precipitation/aggregation of hyperphosphorylated tau protein. The etiology of Alzheimer's disease is multifactorial and a full understanding of its pathogenesis remains elusive. Some years ago, it has been suggested that glycation may contribute to both extensive protein cross-linking and oxidative stress in Alzheimer's disease. Glycation is an endogenous process that leads to the production of a class of compounds known as advanced glycation end products (AGEs). Interestingly, increased levels of AGEs have been observed in brains of Alzheimer's disease patients. Methylglyoxal, a reactive intermediate of cellular metabolism, is the most potent precursor of AGEs and is strictly correlated with an increase of oxidative stress in Alzheimer's disease. Many studies are showing that methylglyoxal and methylglyoxal-derived AGEs play a key role in the etiopathogenesis of Alzheimer's disease.

Authors+Show Affiliations

Department for Life Quality Studies, Alma Mater Studiorum, University of Bologna, Corso d'Augusto 237, 47900 Rimini, Italy.Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy.Department for Life Quality Studies, Alma Mater Studiorum, University of Bologna, Corso d'Augusto 237, 47900 Rimini, Italy.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24734229

Citation

Angeloni, Cristina, et al. "Role of Methylglyoxal in Alzheimer's Disease." BioMed Research International, vol. 2014, 2014, p. 238485.
Angeloni C, Zambonin L, Hrelia S. Role of methylglyoxal in Alzheimer's disease. Biomed Res Int. 2014;2014:238485.
Angeloni, C., Zambonin, L., & Hrelia, S. (2014). Role of methylglyoxal in Alzheimer's disease. BioMed Research International, 2014, p. 238485. doi:10.1155/2014/238485.
Angeloni C, Zambonin L, Hrelia S. Role of Methylglyoxal in Alzheimer's Disease. Biomed Res Int. 2014;2014:238485. PubMed PMID: 24734229.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of methylglyoxal in Alzheimer's disease. AU - Angeloni,Cristina, AU - Zambonin,Laura, AU - Hrelia,Silvana, Y1 - 2014/03/09/ PY - 2013/12/13/received PY - 2014/01/28/revised PY - 2014/01/30/accepted PY - 2014/4/16/entrez PY - 2014/4/16/pubmed PY - 2015/10/1/medline SP - 238485 EP - 238485 JF - BioMed research international JO - Biomed Res Int VL - 2014 N2 - Alzheimer's disease is the most common and lethal neurodegenerative disorder. The major hallmarks of Alzheimer's disease are extracellular aggregation of amyloid β peptides and, the presence of intracellular neurofibrillary tangles formed by precipitation/aggregation of hyperphosphorylated tau protein. The etiology of Alzheimer's disease is multifactorial and a full understanding of its pathogenesis remains elusive. Some years ago, it has been suggested that glycation may contribute to both extensive protein cross-linking and oxidative stress in Alzheimer's disease. Glycation is an endogenous process that leads to the production of a class of compounds known as advanced glycation end products (AGEs). Interestingly, increased levels of AGEs have been observed in brains of Alzheimer's disease patients. Methylglyoxal, a reactive intermediate of cellular metabolism, is the most potent precursor of AGEs and is strictly correlated with an increase of oxidative stress in Alzheimer's disease. Many studies are showing that methylglyoxal and methylglyoxal-derived AGEs play a key role in the etiopathogenesis of Alzheimer's disease. SN - 2314-6141 UR - https://www.unboundmedicine.com/medline/citation/24734229/full_citation L2 - https://dx.doi.org/10.1155/2014/238485 DB - PRIME DP - Unbound Medicine ER -