TY - JOUR T1 - Asymmetric Mukaiyama aldol reactions using chiral diamine-coordinated Sn(II) triflate: development and application to natural product synthesis. A1 - Shiina,Isamu, PY - 2014/4/16/entrez PY - 2014/4/16/pubmed PY - 2014/10/23/medline SP - 144 EP - 83 JF - Chemical record (New York, N.Y.) JO - Chem Rec VL - 14 IS - 1 N2 - In 1989, the asymmetric Mukaiyama aldol reaction mediated by a Lewis acid consisting of a chiral diamine and Sn(II) triflate was reported. The asymmetric Mukaiyama aldol reaction is now widely used as a versatile tool for the construction of highly advanced, multifunctionalized molecules. In this Personal Account, the history of the development of this powerful methodology and the application of the asymmetric Mukaiyama aldol reaction in the synthesis of natural products are reviewed. SN - 1528-0691 UR - https://www.unboundmedicine.com/medline/citation/24734309/Asymmetric_Mukaiyama_aldol_reactions_using_chiral_diamine_coordinated_Sn_II__triflate:_development_and_application_to_natural_product_synthesis_ DB - PRIME DP - Unbound Medicine ER -