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[Evaluation of LOXL1 polymorphisms in exfoliation syndrome in the Uygur population].
Zhonghua Yan Ke Za Zhi. 2014 Feb; 50(2):126-32.ZY

Abstract

OBJECTIVE

In this study, we evaluate the association profiles of the lysyl oxidase-like 1 (LOXL1) gene polymorphisms with exfoliation syndrome in XFS Uygur population.

METHODS

Case-control study. Sixty-four unrelated Uygur patients with XFS (including 7 patients with Exfoliation Syndrome Glaucoma) and 127 Uygur control subjects were included. All of control subjects were selected from the same area, passed through the same ophthalmic checks and confirmed without any expressions of XFS. Most of them suffered from cataract and other ophthalmic disease.Genotypes of the three single nucleotide polymorphisms (SNPs) of LOXL1 (rs1048661, rs2165241 and rs3825942) were analyzed by direct sequencing following PCR amplification, and a case-control association study was performed and judged by odd ratio (OR) with (95% confidential interval).

RESULTS

G allele of rs1048661 [OR:1.92 (1.14-3.22)], G of rs3825942 [OR:4.86 (2.02-11.68)], and T of rs2165241[OR:3.98 (2.54-6.25)] were risk alleles for the disorder. The genotypes TT for rs2165241 [OR:2.20 (1.04-4.65)] were risk genotypes for the disease.

CONCLUSION

LOXL1 is a susceptibility gene of XFS in the Uygur populations. The risk alleles of rs1048661, rs3825942 and rs2165241 in Uygur subjects were identified to be significantly associated with XFS individually.

Authors+Show Affiliations

Department of Ophthalmology, the First Affiliated Hospital of Xinjiang Medical University,Xinjiang 830054, China.Department of Ophthalmology, the First Affiliated Hospital of Xinjiang Medical University,Xinjiang 830054, China.Department of Ophthalmology, the First Affiliated Hospital of Xinjiang Medical University,Xinjiang 830054, China.Department of Ophthalmology, the First Affiliated Hospital of Xinjiang Medical University,Xinjiang 830054, China. Email:ykangle@163.com.

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

24735667

Citation

Ma, Yinu, et al. "[Evaluation of LOXL1 Polymorphisms in Exfoliation Syndrome in the Uygur Population]." [Zhonghua Yan Ke Za Zhi] Chinese Journal of Ophthalmology, vol. 50, no. 2, 2014, pp. 126-32.
Ma Y, Xie T, Zhu G, et al. [Evaluation of LOXL1 polymorphisms in exfoliation syndrome in the Uygur population]. Zhonghua Yan Ke Za Zhi. 2014;50(2):126-32.
Ma, Y., Xie, T., Zhu, G., & Chen, X. (2014). [Evaluation of LOXL1 polymorphisms in exfoliation syndrome in the Uygur population]. [Zhonghua Yan Ke Za Zhi] Chinese Journal of Ophthalmology, 50(2), 126-32.
Ma Y, et al. [Evaluation of LOXL1 Polymorphisms in Exfoliation Syndrome in the Uygur Population]. Zhonghua Yan Ke Za Zhi. 2014;50(2):126-32. PubMed PMID: 24735667.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Evaluation of LOXL1 polymorphisms in exfoliation syndrome in the Uygur population]. AU - Ma,Yinu, AU - Xie,Tingyu, AU - Zhu,Guowei, AU - Chen,Xueyi, PY - 2014/4/17/entrez PY - 2014/4/17/pubmed PY - 2015/2/20/medline SP - 126 EP - 32 JF - [Zhonghua yan ke za zhi] Chinese journal of ophthalmology JO - Zhonghua Yan Ke Za Zhi VL - 50 IS - 2 N2 - OBJECTIVE: In this study, we evaluate the association profiles of the lysyl oxidase-like 1 (LOXL1) gene polymorphisms with exfoliation syndrome in XFS Uygur population. METHODS: Case-control study. Sixty-four unrelated Uygur patients with XFS (including 7 patients with Exfoliation Syndrome Glaucoma) and 127 Uygur control subjects were included. All of control subjects were selected from the same area, passed through the same ophthalmic checks and confirmed without any expressions of XFS. Most of them suffered from cataract and other ophthalmic disease.Genotypes of the three single nucleotide polymorphisms (SNPs) of LOXL1 (rs1048661, rs2165241 and rs3825942) were analyzed by direct sequencing following PCR amplification, and a case-control association study was performed and judged by odd ratio (OR) with (95% confidential interval). RESULTS: G allele of rs1048661 [OR:1.92 (1.14-3.22)], G of rs3825942 [OR:4.86 (2.02-11.68)], and T of rs2165241[OR:3.98 (2.54-6.25)] were risk alleles for the disorder. The genotypes TT for rs2165241 [OR:2.20 (1.04-4.65)] were risk genotypes for the disease. CONCLUSION: LOXL1 is a susceptibility gene of XFS in the Uygur populations. The risk alleles of rs1048661, rs3825942 and rs2165241 in Uygur subjects were identified to be significantly associated with XFS individually. SN - 0412-4081 UR - https://www.unboundmedicine.com/medline/citation/24735667/[Evaluation_of_LOXL1_polymorphisms_in_exfoliation_syndrome_in_the_Uygur_population]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=0412-4081&year=2014&vol=50&issue=2&fpage=126 DB - PRIME DP - Unbound Medicine ER -