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Glucose hypometabolism is highly localized, but lower cortical thickness and brain atrophy are widespread in cognitively normal older adults.
Am J Physiol Endocrinol Metab 2014; 306(11):E1315-21AJ

Abstract

Several studies have suggested that glucose hypometabolism may be present in specific brain regions in cognitively normal older adults and could contribute to the risk of subsequent cognitive decline. However, certain methodological shortcomings, including a lack of partial volume effect (PVE) correction or insufficient cognitive testing, confound the interpretation of most studies on this topic. We combined [(18)F]fluorodeoxyglucose ([(18)F]FDG) positron emission tomography (PET) and magnetic resonance (MR) imaging to quantify cerebral metabolic rate of glucose (CMRg) as well as cortical volume and thickness in 43 anatomically defined brain regions from a group of cognitively normal younger (25 ± 3 yr old; n = 25) and older adults (71 ± 9 yr old; n = 31). After correcting for PVE, we observed 11-17% lower CMRg in three specific brain regions of the older group: the superior frontal cortex, the caudal middle frontal cortex, and the caudate (P ≤ 0.01 false discovery rate-corrected). In the older group, cortical volumes and cortical thickness were 13-33 and 7-18% lower, respectively, in multiple brain regions (P ≤ 0.01 FDR correction). There were no differences in CMRg between individuals who were or were not prescribed antihypertensive medication. There were no significant correlations between CMRg and cognitive performance or metabolic parameters measured in fasting plasma. We conclude that highly localized glucose hypometabolism and widespread cortical thinning and atrophy can be present in older adults who are cognitively normal, as assessed using age-normed neuropsychological testing measures.

Authors+Show Affiliations

Research Center on Aging, Departments of Physiology and Biophysics, Scott.Nugent@USherbrooke.ca.Research Center on Aging, Medicine.Centre Hospitalier Universitaire de Sherbrooke Research Center, Université de Sherbrooke, Sherbrooke, Quebec, Canada.Nuclear Medicine and Radiobiology, and Sherbrooke Molecular Imaging Center, and.Nuclear Medicine and Radiobiology, and Sherbrooke Molecular Imaging Center, and.Nuclear Medicine and Radiobiology, and.Research Center on Aging, Medicine.Research Center on Aging, Medicine.Research Center on Aging, Departments of Physiology and Biophysics, Medicine.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24735889

Citation

Nugent, Scott, et al. "Glucose Hypometabolism Is Highly Localized, but Lower Cortical Thickness and Brain Atrophy Are Widespread in Cognitively Normal Older Adults." American Journal of Physiology. Endocrinology and Metabolism, vol. 306, no. 11, 2014, pp. E1315-21.
Nugent S, Castellano CA, Goffaux P, et al. Glucose hypometabolism is highly localized, but lower cortical thickness and brain atrophy are widespread in cognitively normal older adults. Am J Physiol Endocrinol Metab. 2014;306(11):E1315-21.
Nugent, S., Castellano, C. A., Goffaux, P., Whittingstall, K., Lepage, M., Paquet, N., ... Cunnane, S. C. (2014). Glucose hypometabolism is highly localized, but lower cortical thickness and brain atrophy are widespread in cognitively normal older adults. American Journal of Physiology. Endocrinology and Metabolism, 306(11), pp. E1315-21. doi:10.1152/ajpendo.00067.2014.
Nugent S, et al. Glucose Hypometabolism Is Highly Localized, but Lower Cortical Thickness and Brain Atrophy Are Widespread in Cognitively Normal Older Adults. Am J Physiol Endocrinol Metab. 2014 Jun 1;306(11):E1315-21. PubMed PMID: 24735889.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glucose hypometabolism is highly localized, but lower cortical thickness and brain atrophy are widespread in cognitively normal older adults. AU - Nugent,Scott, AU - Castellano,Christian-Alexandre, AU - Goffaux,Philippe, AU - Whittingstall,Kevin, AU - Lepage,Martin, AU - Paquet,Nancy, AU - Bocti,Christian, AU - Fulop,Tamas, AU - Cunnane,Stephen C, Y1 - 2014/04/15/ PY - 2014/4/17/entrez PY - 2014/4/17/pubmed PY - 2014/7/23/medline KW - aging KW - cerebral glucose metabolism KW - cortical thickness KW - cortical volume KW - positron emission tomography SP - E1315 EP - 21 JF - American journal of physiology. Endocrinology and metabolism JO - Am. J. Physiol. Endocrinol. Metab. VL - 306 IS - 11 N2 - Several studies have suggested that glucose hypometabolism may be present in specific brain regions in cognitively normal older adults and could contribute to the risk of subsequent cognitive decline. However, certain methodological shortcomings, including a lack of partial volume effect (PVE) correction or insufficient cognitive testing, confound the interpretation of most studies on this topic. We combined [(18)F]fluorodeoxyglucose ([(18)F]FDG) positron emission tomography (PET) and magnetic resonance (MR) imaging to quantify cerebral metabolic rate of glucose (CMRg) as well as cortical volume and thickness in 43 anatomically defined brain regions from a group of cognitively normal younger (25 ± 3 yr old; n = 25) and older adults (71 ± 9 yr old; n = 31). After correcting for PVE, we observed 11-17% lower CMRg in three specific brain regions of the older group: the superior frontal cortex, the caudal middle frontal cortex, and the caudate (P ≤ 0.01 false discovery rate-corrected). In the older group, cortical volumes and cortical thickness were 13-33 and 7-18% lower, respectively, in multiple brain regions (P ≤ 0.01 FDR correction). There were no differences in CMRg between individuals who were or were not prescribed antihypertensive medication. There were no significant correlations between CMRg and cognitive performance or metabolic parameters measured in fasting plasma. We conclude that highly localized glucose hypometabolism and widespread cortical thinning and atrophy can be present in older adults who are cognitively normal, as assessed using age-normed neuropsychological testing measures. SN - 1522-1555 UR - https://www.unboundmedicine.com/medline/citation/24735889/Glucose_hypometabolism_is_highly_localized_but_lower_cortical_thickness_and_brain_atrophy_are_widespread_in_cognitively_normal_older_adults_ L2 - http://www.physiology.org/doi/full/10.1152/ajpendo.00067.2014?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -