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Effect of statin on risk of gynecologic cancers: a meta-analysis of observational studies and randomized controlled trials.
Gynecol Oncol. 2014 Jun; 133(3):647-55.GO

Abstract

Objective.

Epidemiologic and clinical findings are inconsistent concerning the risk for gynecologic cancers associated with statin use. We conducted a detailed meta-analysis of all relevant original studies to evaluate the effects of statin on the risk of gynecologic cancers. Methods. We searched PubMed, Embase, and Cochrane library databases up to February 2014 looking for eligible studies. Summary relative risk (RR) estimates and 95% confidence intervals (CIs) were used to calculate the risk using random-effects models.

Results.

A total of 14 (4 randomized controlled trials, 5 cohorts, and 5 case-control) studies, involving 12,904 gynecologic cancer cases, contributed to the analysis. Pooled results indicated a non-significant decrease of total gynecologic cancer risk among statin users (RR=0.89; 95% CI, 0.78-1.01). Stratified analyses across cancer site revealed a modest protective effect of statin on ovarian cancer (RR=0.79; 95% CI, 0.64-0.98), while no association was found for endometrial cancer (RR=0.90; 95% CI, 0.75-1.07). The effect of statin use against cervical cancer and vulvar cancer is not conclusive. Furthermore, long-term statin use (>5years use) did not significantly affect the risk of endometrial cancer (RR=0.69; 95% CI, 0.44-1.10), but had an obvious decrease on the risk of ovarian cancer (RR=0.48; 95% CI, 0.28-0.80).

Conclusions.

Our results suggest that statin use was inversely associated with ovarian cancer risk, and the association was stronger for long-term statin use (>5years). The evidence for a protective effect of statin use against other gynecologic cancers is suggestive but not conclusive, which deserves further investigation.

Authors+Show Affiliations

Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.Department of Obstetrics and Gynecology and Reproductive center, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. Electronic address: lis8858@126.com.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

24736024

Citation

Liu, Yanqiong, et al. "Effect of Statin On Risk of Gynecologic Cancers: a Meta-analysis of Observational Studies and Randomized Controlled Trials." Gynecologic Oncology, vol. 133, no. 3, 2014, pp. 647-55.
Liu Y, Qin A, Li T, et al. Effect of statin on risk of gynecologic cancers: a meta-analysis of observational studies and randomized controlled trials. Gynecol Oncol. 2014;133(3):647-55.
Liu, Y., Qin, A., Li, T., Qin, X., & Li, S. (2014). Effect of statin on risk of gynecologic cancers: a meta-analysis of observational studies and randomized controlled trials. Gynecologic Oncology, 133(3), 647-55. https://doi.org/10.1016/j.ygyno.2014.04.007
Liu Y, et al. Effect of Statin On Risk of Gynecologic Cancers: a Meta-analysis of Observational Studies and Randomized Controlled Trials. Gynecol Oncol. 2014;133(3):647-55. PubMed PMID: 24736024.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of statin on risk of gynecologic cancers: a meta-analysis of observational studies and randomized controlled trials. AU - Liu,Yanqiong, AU - Qin,Aiping, AU - Li,Taijie, AU - Qin,Xue, AU - Li,Shan, Y1 - 2014/04/13/ PY - 2014/03/04/received PY - 2014/04/03/revised PY - 2014/04/06/accepted PY - 2014/4/17/entrez PY - 2014/4/17/pubmed PY - 2014/7/17/medline KW - Cervical cancer KW - Endometrial cancer KW - Gynecologic cancers KW - Ovarian cancer KW - Statin SP - 647 EP - 55 JF - Gynecologic oncology JO - Gynecol. Oncol. VL - 133 IS - 3 N2 - Objective. Epidemiologic and clinical findings are inconsistent concerning the risk for gynecologic cancers associated with statin use. We conducted a detailed meta-analysis of all relevant original studies to evaluate the effects of statin on the risk of gynecologic cancers. Methods. We searched PubMed, Embase, and Cochrane library databases up to February 2014 looking for eligible studies. Summary relative risk (RR) estimates and 95% confidence intervals (CIs) were used to calculate the risk using random-effects models. Results. A total of 14 (4 randomized controlled trials, 5 cohorts, and 5 case-control) studies, involving 12,904 gynecologic cancer cases, contributed to the analysis. Pooled results indicated a non-significant decrease of total gynecologic cancer risk among statin users (RR=0.89; 95% CI, 0.78-1.01). Stratified analyses across cancer site revealed a modest protective effect of statin on ovarian cancer (RR=0.79; 95% CI, 0.64-0.98), while no association was found for endometrial cancer (RR=0.90; 95% CI, 0.75-1.07). The effect of statin use against cervical cancer and vulvar cancer is not conclusive. Furthermore, long-term statin use (>5years use) did not significantly affect the risk of endometrial cancer (RR=0.69; 95% CI, 0.44-1.10), but had an obvious decrease on the risk of ovarian cancer (RR=0.48; 95% CI, 0.28-0.80). Conclusions. Our results suggest that statin use was inversely associated with ovarian cancer risk, and the association was stronger for long-term statin use (>5years). The evidence for a protective effect of statin use against other gynecologic cancers is suggestive but not conclusive, which deserves further investigation. SN - 1095-6859 UR - https://www.unboundmedicine.com/medline/citation/24736024/Effect_of_statin_on_risk_of_gynecologic_cancers:_a_meta_analysis_of_observational_studies_and_randomized_controlled_trials_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-8258(14)00864-6 DB - PRIME DP - Unbound Medicine ER -