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Asymmetrical recovery of cone outer segment tips line and foveal displacement after successful macular hole surgery.
Invest Ophthalmol Vis Sci. 2014 May 06; 55(5):3003-11.IO

Abstract

PURPOSE

To determine whether the photoreceptor outer segments recover symmetrically after successful macular hole surgery, and whether the recovery is correlated with the degree of foveal displacement.

METHODS

This was a retrospective, interventional case series. The medical records of 35 patients (n = 35 eyes) with a surgically closed macular hole were reviewed. Spectral-domain optical coherence tomography (SD-OCT) was used to obtain cross-sectional images across the fovea horizontally and vertically. The lengths of cone outer segment tips (COST) line defect in the temporal, nasal, superior, and inferior sectors of the fovea, the best-corrected visual acuity (BCVA), and the papillofoveal distance were measured before and at 6 and 12 months after the surgery.

RESULTS

The temporal COST line defect was significantly longer than the nasal length defect preoperatively (P = 0.031), at 6 months (P < 0.001), and at 12 months (P = 0.038) postoperatively. The length of the temporal COST line defect was significantly correlated with the BCVA preoperatively (P = 0.014) and at 6 months postoperatively (P = 0.001). The papillofoveal distance was significantly shorter at 6 months (P = 0.029) and 12 months (P = 0.043) postoperatively than at the baseline. The center of the COST line defect was located further temporally from the fovea postoperatively, and the distance was shorter than the nasal foveal displacement at 6 months (158.8 ± 167.0 μm, P = 0.13) and 12 months (244.8 ± 172.7 μm, P = 0.008).

CONCLUSIONS

The restoration of the temporal COST line was delayed after successful macular hole surgery. In addition, the fovea was displaced more nasally than the center of the COST line defect which recovered centripetally. (ClinicalTrials.gov number, NCT01959776.).

Authors+Show Affiliations

Kyorin Eye Center, Kyorin University School of Medicine, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24736052

Citation

Itoh, Yuji, et al. "Asymmetrical Recovery of Cone Outer Segment Tips Line and Foveal Displacement After Successful Macular Hole Surgery." Investigative Ophthalmology & Visual Science, vol. 55, no. 5, 2014, pp. 3003-11.
Itoh Y, Inoue M, Rii T, et al. Asymmetrical recovery of cone outer segment tips line and foveal displacement after successful macular hole surgery. Invest Ophthalmol Vis Sci. 2014;55(5):3003-11.
Itoh, Y., Inoue, M., Rii, T., Ando, Y., & Hirakata, A. (2014). Asymmetrical recovery of cone outer segment tips line and foveal displacement after successful macular hole surgery. Investigative Ophthalmology & Visual Science, 55(5), 3003-11. https://doi.org/10.1167/iovs.14-13973
Itoh Y, et al. Asymmetrical Recovery of Cone Outer Segment Tips Line and Foveal Displacement After Successful Macular Hole Surgery. Invest Ophthalmol Vis Sci. 2014 May 6;55(5):3003-11. PubMed PMID: 24736052.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Asymmetrical recovery of cone outer segment tips line and foveal displacement after successful macular hole surgery. AU - Itoh,Yuji, AU - Inoue,Makoto, AU - Rii,Tosho, AU - Ando,Yoshimasa, AU - Hirakata,Akito, Y1 - 2014/05/06/ PY - 2014/4/17/entrez PY - 2014/4/17/pubmed PY - 2014/6/24/medline KW - cone outer segment tips line KW - idiopathic macular hole KW - spectral-domain optical coherence tomography KW - vitrectomy SP - 3003 EP - 11 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 55 IS - 5 N2 - PURPOSE: To determine whether the photoreceptor outer segments recover symmetrically after successful macular hole surgery, and whether the recovery is correlated with the degree of foveal displacement. METHODS: This was a retrospective, interventional case series. The medical records of 35 patients (n = 35 eyes) with a surgically closed macular hole were reviewed. Spectral-domain optical coherence tomography (SD-OCT) was used to obtain cross-sectional images across the fovea horizontally and vertically. The lengths of cone outer segment tips (COST) line defect in the temporal, nasal, superior, and inferior sectors of the fovea, the best-corrected visual acuity (BCVA), and the papillofoveal distance were measured before and at 6 and 12 months after the surgery. RESULTS: The temporal COST line defect was significantly longer than the nasal length defect preoperatively (P = 0.031), at 6 months (P < 0.001), and at 12 months (P = 0.038) postoperatively. The length of the temporal COST line defect was significantly correlated with the BCVA preoperatively (P = 0.014) and at 6 months postoperatively (P = 0.001). The papillofoveal distance was significantly shorter at 6 months (P = 0.029) and 12 months (P = 0.043) postoperatively than at the baseline. The center of the COST line defect was located further temporally from the fovea postoperatively, and the distance was shorter than the nasal foveal displacement at 6 months (158.8 ± 167.0 μm, P = 0.13) and 12 months (244.8 ± 172.7 μm, P = 0.008). CONCLUSIONS: The restoration of the temporal COST line was delayed after successful macular hole surgery. In addition, the fovea was displaced more nasally than the center of the COST line defect which recovered centripetally. (ClinicalTrials.gov number, NCT01959776.). SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/24736052/Asymmetrical_recovery_of_cone_outer_segment_tips_line_and_foveal_displacement_after_successful_macular_hole_surgery_ L2 - https://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.14-13973 DB - PRIME DP - Unbound Medicine ER -