TY - JOUR T1 - New melatonin-N,N-dibenzyl(N-methyl)amine hybrids: potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease. AU - López-Iglesias,Beatriz, AU - Pérez,Concepción, AU - Morales-García,José A, AU - Alonso-Gil,Sandra, AU - Pérez-Castillo,Ana, AU - Romero,Alejandro, AU - López,Manuela G, AU - Villarroya,Mercedes, AU - Conde,Santiago, AU - Rodríguez-Franco,María Isabel, Y1 - 2014/04/28/ PY - 2014/4/18/entrez PY - 2014/4/18/pubmed PY - 2014/7/11/medline SP - 3773 EP - 85 JF - Journal of medicinal chemistry JO - J Med Chem VL - 57 IS - 9 N2 - Here, we describe a new family of melatonin-N,N-dibenzyl(N-methyl)amine hybrids that show a balanced multifunctional profile covering neurogenic, antioxidant, cholinergic, and neuroprotective properties at low-micromolar concentrations. They promote maturation of neural stem cells into a neuronal phenotype and thus they could contribute to CNS repair. They also protect neural cells against mitochondrial oxidative stress, show antioxidant properties, and inhibit human acetylcholinesterase (AChE). Moreover, they displace propidium from the peripheral anionic site of AChE, preventing the β-amyloid aggregation promoted by AChE. In addition, they show low cell toxicity and can penetrate into the CNS. This multifunctional profile highlights these melatonin-N,N-dibenzyl(N-methyl)amine hybrids as useful prototypes in the research of innovative drugs for Alzheimer's disease. SN - 1520-4804 UR - https://www.unboundmedicine.com/medline/citation/24738476/New_melatonin_NN_dibenzyl_N_methyl_amine_hybrids:_potent_neurogenic_agents_with_antioxidant_cholinergic_and_neuroprotective_properties_as_innovative_drugs_for_Alzheimer's_disease_ DB - PRIME DP - Unbound Medicine ER -