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Mephedrone, methylone and 3,4-methylenedioxypyrovalerone (MDPV) induce conditioned place preference in mice.
Basic Clin Pharmacol Toxicol. 2014 Nov; 115(5):411-6.BC

Abstract

During the last decade, there has been a worldwide increase in popularity and abuse of synthetic cathinones. Common ingredients of the so-called bath salts include mephedrone, methylone and 3,4-methylenedioxypyrovalerone (MDPV). Relatively little information about the pharmacology and addiction potential of these drugs is available. We used the conditioned place preference (CPP) paradigm to explore the reinforcing effects of three different synthetic cathinones. The primary aim of this study was to investigate whether mephedrone, methylone and MDPV induce CPP in mice. The secondary aims were to investigate a possible dose-response CPP and whether the synthetic cathinones induce higher CPP than amphetamine at equal dose. C57BL/6 mice were conditioned to mephedrone, methylone, MDPV and amphetamine at doses of 0.5, 2, 5, 10 or 20 mg/kg (i.p.). During the conditioning, the mice received two training sessions per day for 4 days. All four tested drugs showed a significant place preference compared with controls. Mice conditioned with MDPV (5 and 10 mg/kg) displayed a greater preference score compared to mice conditioned with amphetamine (5 and 10 mg/kg). Our findings show that mephedrone, methylone and MDPV produce CPP equal or higher than amphetamine strongly suggesting addictive properties. Given the public health concern of abuse, future pharmacological studies are necessary to fully understand the effects of these drugs.

Authors+Show Affiliations

Division of Drug Research, Clinical Pharmacology, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24739011

Citation

Karlsson, Louise, et al. "Mephedrone, Methylone and 3,4-methylenedioxypyrovalerone (MDPV) Induce Conditioned Place Preference in Mice." Basic & Clinical Pharmacology & Toxicology, vol. 115, no. 5, 2014, pp. 411-6.
Karlsson L, Andersson M, Kronstrand R, et al. Mephedrone, methylone and 3,4-methylenedioxypyrovalerone (MDPV) induce conditioned place preference in mice. Basic Clin Pharmacol Toxicol. 2014;115(5):411-6.
Karlsson, L., Andersson, M., Kronstrand, R., & Kugelberg, F. C. (2014). Mephedrone, methylone and 3,4-methylenedioxypyrovalerone (MDPV) induce conditioned place preference in mice. Basic & Clinical Pharmacology & Toxicology, 115(5), 411-6. https://doi.org/10.1111/bcpt.12253
Karlsson L, et al. Mephedrone, Methylone and 3,4-methylenedioxypyrovalerone (MDPV) Induce Conditioned Place Preference in Mice. Basic Clin Pharmacol Toxicol. 2014;115(5):411-6. PubMed PMID: 24739011.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mephedrone, methylone and 3,4-methylenedioxypyrovalerone (MDPV) induce conditioned place preference in mice. AU - Karlsson,Louise, AU - Andersson,Mikael, AU - Kronstrand,Robert, AU - Kugelberg,Fredrik C, Y1 - 2014/05/06/ PY - 2014/02/04/received PY - 2014/04/08/accepted PY - 2014/4/18/entrez PY - 2014/4/18/pubmed PY - 2015/10/27/medline SP - 411 EP - 6 JF - Basic & clinical pharmacology & toxicology JO - Basic Clin. Pharmacol. Toxicol. VL - 115 IS - 5 N2 - During the last decade, there has been a worldwide increase in popularity and abuse of synthetic cathinones. Common ingredients of the so-called bath salts include mephedrone, methylone and 3,4-methylenedioxypyrovalerone (MDPV). Relatively little information about the pharmacology and addiction potential of these drugs is available. We used the conditioned place preference (CPP) paradigm to explore the reinforcing effects of three different synthetic cathinones. The primary aim of this study was to investigate whether mephedrone, methylone and MDPV induce CPP in mice. The secondary aims were to investigate a possible dose-response CPP and whether the synthetic cathinones induce higher CPP than amphetamine at equal dose. C57BL/6 mice were conditioned to mephedrone, methylone, MDPV and amphetamine at doses of 0.5, 2, 5, 10 or 20 mg/kg (i.p.). During the conditioning, the mice received two training sessions per day for 4 days. All four tested drugs showed a significant place preference compared with controls. Mice conditioned with MDPV (5 and 10 mg/kg) displayed a greater preference score compared to mice conditioned with amphetamine (5 and 10 mg/kg). Our findings show that mephedrone, methylone and MDPV produce CPP equal or higher than amphetamine strongly suggesting addictive properties. Given the public health concern of abuse, future pharmacological studies are necessary to fully understand the effects of these drugs. SN - 1742-7843 UR - https://www.unboundmedicine.com/medline/citation/24739011/Mephedrone_methylone_and_34_methylenedioxypyrovalerone__MDPV__induce_conditioned_place_preference_in_mice_ L2 - https://doi.org/10.1111/bcpt.12253 DB - PRIME DP - Unbound Medicine ER -