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Protective effects of influenza A (H1N1) pandemic 2009 vaccination against the onset of influenza-like illness and asthma exacerbation in Japanese children.
J Asthma. 2014 Oct; 51(8):825-31.JA

Abstract

BACKGROUND

Vaccination against influenza A(H1N1)pdm09 in Japan started in October 2009. Children with asthma are considered as a high-risk group and are recommended to preferentially receive the vaccine.

OBJECTIVE

To identify the clinical effects of vaccination in Japanese children with and without asthma.

METHODS

We conducted a cross-sectional, questionnaire-based survey to compare vaccination rates, vaccine effectiveness against physician-diagnosed influenza A infection (PDIA), and consecutive asthma exacerbations between children with and without asthma.

RESULTS

Of the 460 children included in this study, those with asthma had higher vaccination rates (46.5%, 67/144) than those without asthma (30.4%, 96/316). Influenza A infections were diagnosed in 28 of 163 vaccinated children (17.2%) compared to 164 of 297 unvaccinated children (55.2%, p < 0.001). Comparison of positive influenza diagnosis rates between vaccinated and unvaccinated children with and without asthma showed that unvaccinated children with asthma had an elevated odds ratio (13.235; 95% confidence interval [CI], 5.564-32.134) and that treatment for asthma exacerbations was needed in a larger proportion of unvaccinated children. Vaccine effectiveness against PDIA was 87% (95% CI, 78-93%) overall, 92% (95% CI, 81-96%) in children with asthma and 81% (95% CI, 63-91%) in children without asthma, respectively.

CONCLUSIONS

The administration of an inactivated, split-virus, non-adjuvanted monovalent A(H1N1)pdm09 vaccine during the pandemic period reduced the number of physician-diagnosed influenza A infections and asthma exacerbations in children with asthma. Therefore, we strongly recommend that high-risk children with a history of asthma receive vaccines during pandemics.

Authors+Show Affiliations

Department of Pediatrics, Disaster Medical Center , Tokyo , Japan .No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24739075

Citation

Yokouchi, Yukako, et al. "Protective Effects of Influenza a (H1N1) Pandemic 2009 Vaccination Against the Onset of Influenza-like Illness and Asthma Exacerbation in Japanese Children." The Journal of Asthma : Official Journal of the Association for the Care of Asthma, vol. 51, no. 8, 2014, pp. 825-31.
Yokouchi Y, Katsumori H, Shirakawa S, et al. Protective effects of influenza A (H1N1) pandemic 2009 vaccination against the onset of influenza-like illness and asthma exacerbation in Japanese children. J Asthma. 2014;51(8):825-31.
Yokouchi, Y., Katsumori, H., Shirakawa, S., Fujiwara, M., Kashima, K., Kozawa, R., & Koike, Y. (2014). Protective effects of influenza A (H1N1) pandemic 2009 vaccination against the onset of influenza-like illness and asthma exacerbation in Japanese children. The Journal of Asthma : Official Journal of the Association for the Care of Asthma, 51(8), 825-31. https://doi.org/10.3109/02770903.2014.915567
Yokouchi Y, et al. Protective Effects of Influenza a (H1N1) Pandemic 2009 Vaccination Against the Onset of Influenza-like Illness and Asthma Exacerbation in Japanese Children. J Asthma. 2014;51(8):825-31. PubMed PMID: 24739075.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effects of influenza A (H1N1) pandemic 2009 vaccination against the onset of influenza-like illness and asthma exacerbation in Japanese children. AU - Yokouchi,Yukako, AU - Katsumori,Hiroshi, AU - Shirakawa,Seigo, AU - Fujiwara,Maya, AU - Kashima,Kyoko, AU - Kozawa,Ryo, AU - Koike,Yuji, Y1 - 2014/05/22/ PY - 2014/4/18/entrez PY - 2014/4/18/pubmed PY - 2014/11/18/medline KW - Asthmatic KW - high-risk group KW - pandemic KW - pediatrics KW - vaccine SP - 825 EP - 31 JF - The Journal of asthma : official journal of the Association for the Care of Asthma JO - J Asthma VL - 51 IS - 8 N2 - BACKGROUND: Vaccination against influenza A(H1N1)pdm09 in Japan started in October 2009. Children with asthma are considered as a high-risk group and are recommended to preferentially receive the vaccine. OBJECTIVE: To identify the clinical effects of vaccination in Japanese children with and without asthma. METHODS: We conducted a cross-sectional, questionnaire-based survey to compare vaccination rates, vaccine effectiveness against physician-diagnosed influenza A infection (PDIA), and consecutive asthma exacerbations between children with and without asthma. RESULTS: Of the 460 children included in this study, those with asthma had higher vaccination rates (46.5%, 67/144) than those without asthma (30.4%, 96/316). Influenza A infections were diagnosed in 28 of 163 vaccinated children (17.2%) compared to 164 of 297 unvaccinated children (55.2%, p < 0.001). Comparison of positive influenza diagnosis rates between vaccinated and unvaccinated children with and without asthma showed that unvaccinated children with asthma had an elevated odds ratio (13.235; 95% confidence interval [CI], 5.564-32.134) and that treatment for asthma exacerbations was needed in a larger proportion of unvaccinated children. Vaccine effectiveness against PDIA was 87% (95% CI, 78-93%) overall, 92% (95% CI, 81-96%) in children with asthma and 81% (95% CI, 63-91%) in children without asthma, respectively. CONCLUSIONS: The administration of an inactivated, split-virus, non-adjuvanted monovalent A(H1N1)pdm09 vaccine during the pandemic period reduced the number of physician-diagnosed influenza A infections and asthma exacerbations in children with asthma. Therefore, we strongly recommend that high-risk children with a history of asthma receive vaccines during pandemics. SN - 1532-4303 UR - https://www.unboundmedicine.com/medline/citation/24739075/Protective_effects_of_influenza_A__H1N1__pandemic_2009_vaccination_against_the_onset_of_influenza_like_illness_and_asthma_exacerbation_in_Japanese_children_ L2 - https://www.tandfonline.com/doi/full/10.3109/02770903.2014.915567 DB - PRIME DP - Unbound Medicine ER -