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A review on the cause-effect relationship between oxidative stress and toxic proteins in the pathogenesis of neurodegenerative diseases.
Rev Med Chir Soc Med Nat Iasi. 2014 Jan-Mar; 118(1):19-27.RM

Abstract

Protein aggregates are the defining pathological feature of human neurodegenerative diseases. Studies have revealed that mutant huntingtin, polyglutamine-expanded ataxin-1 and ataxin-3 can cause elevated levels of reactive oxygen species in neuronal cells. It has also been indicated that the normal host prion protein behaves as an antioxidant, while the neurotoxic peptide based on the sequence of the scrapie isoform increases hydrogen peroxide toxicity in neuronal cultures. Additionally, not only can oxidative stress contribute to the aggregation of beta-amyloid and alpha-synuclein, but both beta-amyloid and alpha-synuclein can induce oxidative damage. Furthermore, oxidative stressors have been shown to play a critical role in neurofibrillary pathology leading to tau hyperphosphorylation. In conclusion, the present review supports a cause-effect relationship between oxidative stress and toxic proteins in the pathogenesis of neurodegenerative disorders.

Authors

No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24741770

Citation

Borza, Liana Rada. "A Review On the Cause-effect Relationship Between Oxidative Stress and Toxic Proteins in the Pathogenesis of Neurodegenerative Diseases." Revista Medico-chirurgicala a Societatii De Medici Si Naturalisti Din Iasi, vol. 118, no. 1, 2014, pp. 19-27.
Borza LR. A review on the cause-effect relationship between oxidative stress and toxic proteins in the pathogenesis of neurodegenerative diseases. Rev Med Chir Soc Med Nat Iasi. 2014;118(1):19-27.
Borza, L. R. (2014). A review on the cause-effect relationship between oxidative stress and toxic proteins in the pathogenesis of neurodegenerative diseases. Revista Medico-chirurgicala a Societatii De Medici Si Naturalisti Din Iasi, 118(1), 19-27.
Borza LR. A Review On the Cause-effect Relationship Between Oxidative Stress and Toxic Proteins in the Pathogenesis of Neurodegenerative Diseases. Rev Med Chir Soc Med Nat Iasi. 2014 Jan-Mar;118(1):19-27. PubMed PMID: 24741770.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A review on the cause-effect relationship between oxidative stress and toxic proteins in the pathogenesis of neurodegenerative diseases. A1 - Borza,Liana Rada, PY - 2014/4/19/entrez PY - 2014/4/20/pubmed PY - 2014/6/17/medline SP - 19 EP - 27 JF - Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi JO - Rev Med Chir Soc Med Nat Iasi VL - 118 IS - 1 N2 - Protein aggregates are the defining pathological feature of human neurodegenerative diseases. Studies have revealed that mutant huntingtin, polyglutamine-expanded ataxin-1 and ataxin-3 can cause elevated levels of reactive oxygen species in neuronal cells. It has also been indicated that the normal host prion protein behaves as an antioxidant, while the neurotoxic peptide based on the sequence of the scrapie isoform increases hydrogen peroxide toxicity in neuronal cultures. Additionally, not only can oxidative stress contribute to the aggregation of beta-amyloid and alpha-synuclein, but both beta-amyloid and alpha-synuclein can induce oxidative damage. Furthermore, oxidative stressors have been shown to play a critical role in neurofibrillary pathology leading to tau hyperphosphorylation. In conclusion, the present review supports a cause-effect relationship between oxidative stress and toxic proteins in the pathogenesis of neurodegenerative disorders. SN - 0048-7848 UR - https://www.unboundmedicine.com/medline/citation/24741770/A_review_on_the_cause_effect_relationship_between_oxidative_stress_and_toxic_proteins_in_the_pathogenesis_of_neurodegenerative_diseases_ L2 - https://medlineplus.gov/degenerativenervediseases.html DB - PRIME DP - Unbound Medicine ER -