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Waist circumference provides an indication of numerous cardiometabolic risk factors in adults with cerebral palsy.
Arch Phys Med Rehabil. 2014 Aug; 95(8):1540-6.AP

Abstract

OBJECTIVE

To report the prevalence of cardiometabolic risk factors in a cohort of adults with cerebral palsy (CP) and to investigate the ability of anthropometric measures to predict these factors.

DESIGN

Cross-sectional study.

SETTING

Testing took place in a laboratory setting.

PARTICIPANTS

Adults with CP (N=55; mean age, 37.5±13.3 y; Gross Motor Function Classification System levels, I-V) participated in this study.

INTERVENTIONS

Not applicable.

MAIN OUTCOME MEASURES

Total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, glucose, insulin, and C-reactive protein levels were measured from a fasting venous blood sample. Insulin resistance was calculated using the Homeostasis Model Assessment (HOMA-IR) index. Blood pressure, body mass index (BMI), waist circumference (WC), waist-hip ratio, and waist-height ratio were also measured. The metabolic syndrome (MetS) was defined according to the 2009 Joint Interim Statement.

RESULTS

The prevalence of the MetS was 20.5% in ambulatory adults and 28.6% in nonambulatory adults. BMI was associated with HOMA-IR only (β=.451; P<.01). WC was associated with HOMA-IR (β=.480; P<.01), triglycerides (β=.450; P<.01), and systolic blood pressure (β=.352; P<.05). Receiver operating characteristic curve analysis revealed that WC provided the best indication of hypertensive blood pressure, dyslipidemia, HOMA-IR, and the presence of multiple risk factors (area under the curve, .713-.763).

CONCLUSIONS

A high prevalence of the MetS was observed in this relatively young sample of adults with CP. WC was a better indicator of a number of risk factors than was BMI and presents as a clinically useful method of screening for cardiometabolic risk among adults with CP.

Authors+Show Affiliations

School of Medicine, Trinity College Dublin, Ireland. Electronic address: Jennifer.Ryan@brunel.ac.uk.Department of Biochemistry, St James's Hospital, Dublin, Ireland.Central Remedial Clinic, Clontarf, Dublin, Ireland.Central Remedial Clinic, Clontarf, Dublin, Ireland.School of Medicine, Trinity College Dublin, Ireland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24742941

Citation

Ryan, Jennifer M., et al. "Waist Circumference Provides an Indication of Numerous Cardiometabolic Risk Factors in Adults With Cerebral Palsy." Archives of Physical Medicine and Rehabilitation, vol. 95, no. 8, 2014, pp. 1540-6.
Ryan JM, Crowley VE, Hensey O, et al. Waist circumference provides an indication of numerous cardiometabolic risk factors in adults with cerebral palsy. Arch Phys Med Rehabil. 2014;95(8):1540-6.
Ryan, J. M., Crowley, V. E., Hensey, O., McGahey, A., & Gormley, J. (2014). Waist circumference provides an indication of numerous cardiometabolic risk factors in adults with cerebral palsy. Archives of Physical Medicine and Rehabilitation, 95(8), 1540-6. https://doi.org/10.1016/j.apmr.2014.03.029
Ryan JM, et al. Waist Circumference Provides an Indication of Numerous Cardiometabolic Risk Factors in Adults With Cerebral Palsy. Arch Phys Med Rehabil. 2014;95(8):1540-6. PubMed PMID: 24742941.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Waist circumference provides an indication of numerous cardiometabolic risk factors in adults with cerebral palsy. AU - Ryan,Jennifer M, AU - Crowley,Vivion E, AU - Hensey,Owen, AU - McGahey,Ailish, AU - Gormley,John, Y1 - 2014/04/15/ PY - 2014/01/27/received PY - 2014/03/24/revised PY - 2014/03/27/accepted PY - 2014/4/19/entrez PY - 2014/4/20/pubmed PY - 2014/9/23/medline KW - Body mass index KW - Cardiovascular diseases KW - Cerebral palsy KW - Metabolic syndrome X KW - Rehabilitation KW - Risk factors KW - Waist circumference SP - 1540 EP - 6 JF - Archives of physical medicine and rehabilitation JO - Arch Phys Med Rehabil VL - 95 IS - 8 N2 - OBJECTIVE: To report the prevalence of cardiometabolic risk factors in a cohort of adults with cerebral palsy (CP) and to investigate the ability of anthropometric measures to predict these factors. DESIGN: Cross-sectional study. SETTING: Testing took place in a laboratory setting. PARTICIPANTS: Adults with CP (N=55; mean age, 37.5±13.3 y; Gross Motor Function Classification System levels, I-V) participated in this study. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, glucose, insulin, and C-reactive protein levels were measured from a fasting venous blood sample. Insulin resistance was calculated using the Homeostasis Model Assessment (HOMA-IR) index. Blood pressure, body mass index (BMI), waist circumference (WC), waist-hip ratio, and waist-height ratio were also measured. The metabolic syndrome (MetS) was defined according to the 2009 Joint Interim Statement. RESULTS: The prevalence of the MetS was 20.5% in ambulatory adults and 28.6% in nonambulatory adults. BMI was associated with HOMA-IR only (β=.451; P<.01). WC was associated with HOMA-IR (β=.480; P<.01), triglycerides (β=.450; P<.01), and systolic blood pressure (β=.352; P<.05). Receiver operating characteristic curve analysis revealed that WC provided the best indication of hypertensive blood pressure, dyslipidemia, HOMA-IR, and the presence of multiple risk factors (area under the curve, .713-.763). CONCLUSIONS: A high prevalence of the MetS was observed in this relatively young sample of adults with CP. WC was a better indicator of a number of risk factors than was BMI and presents as a clinically useful method of screening for cardiometabolic risk among adults with CP. SN - 1532-821X UR - https://www.unboundmedicine.com/medline/citation/24742941/Waist_circumference_provides_an_indication_of_numerous_cardiometabolic_risk_factors_in_adults_with_cerebral_palsy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-9993(14)00280-9 DB - PRIME DP - Unbound Medicine ER -