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Comparison by computed tomographic angiography-the presence and extent of coronary arterial atherosclerosis in South Asians versus Caucasians with diabetes mellitus.
Am J Cardiol. 2014 Jun 01; 113(11):1782-7.AJ

Abstract

South Asians in the Western world have a high prevalence of diabetes mellitus (DM) and an increased risk of coronary artery disease (CAD) and mortality compared with Caucasians. CAD in asymptomatic South Asian patients with type 2 DM has not been investigated. The aim of this observational cohort study was to investigate CAD in asymptomatic South Asian patients with type 2 DM and to compare with matched Caucasian patients. A total of 120 asymptomatic South Asian patients with type 2 DM and matched Caucasian patients (mean age 52 years, 55% men) were derived from an ongoing registry of cardiovascular risk stratification in asymptomatic patients with DM. Cardiovascular risk assessment included multidetector row coronary computed tomography angiography. CAD was assessed as the coronary artery calcium score and classified into no signs of atherosclerosis or minor wall irregularities <30%, nonsignificant CAD 30% to 50%, or significant CAD ≥50% stenosis. On a patient base, CAD was scored according to the severity and number of vessels and segments with significant CAD. Subsequently, CAD was assessed per coronary artery and per segment. Compared with Caucasian patients, South Asian patients had a significantly higher coronary artery calcium score and higher prevalence of significant CAD (41% vs 28%, respectively, p = 0.008), involving more coronary vessels and segments. Significant CAD was especially more frequent in the left anterior descending coronary artery. In conclusion, asymptomatic South Asian patients with type 2 DM have a higher prevalence and extent of CAD compared with matched Caucasian patients.

Authors+Show Affiliations

Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands; The Interuniversity Cardiology Institute of The Netherlands, Utrecht, The Netherlands.Department of Internal Medicine, Medical Center Haaglanden, The Hague, The Netherlands; Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands.Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands; The Interuniversity Cardiology Institute of The Netherlands, Utrecht, The Netherlands.Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: a.j.h.a.scholte@lumc.nl.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24746030

Citation

Roos, Cornelis J., et al. "Comparison By Computed Tomographic Angiography-the Presence and Extent of Coronary Arterial Atherosclerosis in South Asians Versus Caucasians With Diabetes Mellitus." The American Journal of Cardiology, vol. 113, no. 11, 2014, pp. 1782-7.
Roos CJ, Kharagjitsingh AV, Jukema JW, et al. Comparison by computed tomographic angiography-the presence and extent of coronary arterial atherosclerosis in South Asians versus Caucasians with diabetes mellitus. Am J Cardiol. 2014;113(11):1782-7.
Roos, C. J., Kharagjitsingh, A. V., Jukema, J. W., Bax, J. J., & Scholte, A. J. (2014). Comparison by computed tomographic angiography-the presence and extent of coronary arterial atherosclerosis in South Asians versus Caucasians with diabetes mellitus. The American Journal of Cardiology, 113(11), 1782-7. https://doi.org/10.1016/j.amjcard.2014.03.005
Roos CJ, et al. Comparison By Computed Tomographic Angiography-the Presence and Extent of Coronary Arterial Atherosclerosis in South Asians Versus Caucasians With Diabetes Mellitus. Am J Cardiol. 2014 Jun 1;113(11):1782-7. PubMed PMID: 24746030.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison by computed tomographic angiography-the presence and extent of coronary arterial atherosclerosis in South Asians versus Caucasians with diabetes mellitus. AU - Roos,Cornelis J, AU - Kharagjitsingh,Aantje V, AU - Jukema,J Wouter, AU - Bax,Jeroen J, AU - Scholte,Arthur J, Y1 - 2014/03/15/ PY - 2014/01/13/received PY - 2014/03/05/revised PY - 2014/03/05/accepted PY - 2014/4/22/entrez PY - 2014/4/22/pubmed PY - 2014/7/9/medline SP - 1782 EP - 7 JF - The American journal of cardiology JO - Am J Cardiol VL - 113 IS - 11 N2 - South Asians in the Western world have a high prevalence of diabetes mellitus (DM) and an increased risk of coronary artery disease (CAD) and mortality compared with Caucasians. CAD in asymptomatic South Asian patients with type 2 DM has not been investigated. The aim of this observational cohort study was to investigate CAD in asymptomatic South Asian patients with type 2 DM and to compare with matched Caucasian patients. A total of 120 asymptomatic South Asian patients with type 2 DM and matched Caucasian patients (mean age 52 years, 55% men) were derived from an ongoing registry of cardiovascular risk stratification in asymptomatic patients with DM. Cardiovascular risk assessment included multidetector row coronary computed tomography angiography. CAD was assessed as the coronary artery calcium score and classified into no signs of atherosclerosis or minor wall irregularities <30%, nonsignificant CAD 30% to 50%, or significant CAD ≥50% stenosis. On a patient base, CAD was scored according to the severity and number of vessels and segments with significant CAD. Subsequently, CAD was assessed per coronary artery and per segment. Compared with Caucasian patients, South Asian patients had a significantly higher coronary artery calcium score and higher prevalence of significant CAD (41% vs 28%, respectively, p = 0.008), involving more coronary vessels and segments. Significant CAD was especially more frequent in the left anterior descending coronary artery. In conclusion, asymptomatic South Asian patients with type 2 DM have a higher prevalence and extent of CAD compared with matched Caucasian patients. SN - 1879-1913 UR - https://www.unboundmedicine.com/medline/citation/24746030/Comparison_by_computed_tomographic_angiography_the_presence_and_extent_of_coronary_arterial_atherosclerosis_in_South_Asians_versus_Caucasians_with_diabetes_mellitus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(14)00794-2 DB - PRIME DP - Unbound Medicine ER -