Tags

Type your tag names separated by a space and hit enter

Epithelial HLA-DR expression in labial salivary glands in Sjögren's syndrome and non-specific sialadenitis.
J Oral Pathol Med. 1989 Mar; 18(3):178-83.JO

Abstract

The expression of the Class II major histocompatibility antigen HLA-DR was quantified in the epithelial cells of labial salivary glands from patients with Sjögrens Syndrome (SS) and compared with similar expression in glands showing non-specific sialadenitis and normal controls. In all glands more duct cells were positive than acinar cells but only in sialadenitis and SS was strong epithelial staining seen. The proportions of duct and acinar cells expressing HLA-DR were increased between normals and sialadenitis (P less than 0.01) and between sialadenitis and SS (P less than 0.001). However, for all cases increased expression of HLA-DR correlated to the increased proportion of inflammatory cells in the gland (P less than 0.01). The results indicate that although HLA-DR is expressed on the epithelial cells in the glandular lesions of SS, this is not specific as it is also seen in sialadenitis. This supports the view that such expression is secondary to an inflammatory infiltrate and may not be of importance in initiating autoimmune tissue damage.

Authors+Show Affiliations

Department of Oral Pathology, London Hospital Medical College, England.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

2474646

Citation

Speight, P M., et al. "Epithelial HLA-DR Expression in Labial Salivary Glands in Sjögren's Syndrome and Non-specific Sialadenitis." Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, vol. 18, no. 3, 1989, pp. 178-83.
Speight PM, Cruchley A, Williams DM. Epithelial HLA-DR expression in labial salivary glands in Sjögren's syndrome and non-specific sialadenitis. J Oral Pathol Med. 1989;18(3):178-83.
Speight, P. M., Cruchley, A., & Williams, D. M. (1989). Epithelial HLA-DR expression in labial salivary glands in Sjögren's syndrome and non-specific sialadenitis. Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 18(3), 178-83.
Speight PM, Cruchley A, Williams DM. Epithelial HLA-DR Expression in Labial Salivary Glands in Sjögren's Syndrome and Non-specific Sialadenitis. J Oral Pathol Med. 1989;18(3):178-83. PubMed PMID: 2474646.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epithelial HLA-DR expression in labial salivary glands in Sjögren's syndrome and non-specific sialadenitis. AU - Speight,P M, AU - Cruchley,A, AU - Williams,D M, PY - 1989/3/1/pubmed PY - 1989/3/1/medline PY - 1989/3/1/entrez SP - 178 EP - 83 JF - Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology JO - J Oral Pathol Med VL - 18 IS - 3 N2 - The expression of the Class II major histocompatibility antigen HLA-DR was quantified in the epithelial cells of labial salivary glands from patients with Sjögrens Syndrome (SS) and compared with similar expression in glands showing non-specific sialadenitis and normal controls. In all glands more duct cells were positive than acinar cells but only in sialadenitis and SS was strong epithelial staining seen. The proportions of duct and acinar cells expressing HLA-DR were increased between normals and sialadenitis (P less than 0.01) and between sialadenitis and SS (P less than 0.001). However, for all cases increased expression of HLA-DR correlated to the increased proportion of inflammatory cells in the gland (P less than 0.01). The results indicate that although HLA-DR is expressed on the epithelial cells in the glandular lesions of SS, this is not specific as it is also seen in sialadenitis. This supports the view that such expression is secondary to an inflammatory infiltrate and may not be of importance in initiating autoimmune tissue damage. SN - 0904-2512 UR - https://www.unboundmedicine.com/medline/citation/2474646/Epithelial_HLA_DR_expression_in_labial_salivary_glands_in_Sjögren's_syndrome_and_non_specific_sialadenitis_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0904-2512&date=1989&volume=18&issue=3&spage=178 DB - PRIME DP - Unbound Medicine ER -