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Hydrogen sulfide in hemostasis: friend or foe?
Chem Biol Interact. 2014 Jun 25; 217:49-56.CB

Abstract

Hydrogen sulfide (H2S) is a well known toxic gas that is synthesized from the amino acids: cysteine (Cys) and homocysteine (Hcy) by three enzymes: cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE) and mercaptopyruvate sulfurtransferase (3-MST). Hydrogen sulfide, like carbon monoxide (CO) or nitric oxide (NO) is a signaling molecule in different biological systems, including the cardiovascular system. Moreover, hydrogen sulfide plays a role in the pathogenesis of various cardiovascular diseases. It modulates different elements of hemostasis (activation of blood platelet, and coagulation process) as well as proliferation and apoptosis of vascular smooth muscle cells. However, the biological role and the therapeutic potential of H2S is not clear. This review summarizes the different functions of hydrogen sulfide in hemostasis.

Authors+Show Affiliations

Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland. Electronic address: olasb@biol.uni.lodz.pl.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24746521

Citation

Olas, Beata. "Hydrogen Sulfide in Hemostasis: Friend or Foe?" Chemico-biological Interactions, vol. 217, 2014, pp. 49-56.
Olas B. Hydrogen sulfide in hemostasis: friend or foe? Chem Biol Interact. 2014;217:49-56.
Olas, B. (2014). Hydrogen sulfide in hemostasis: friend or foe? Chemico-biological Interactions, 217, 49-56. https://doi.org/10.1016/j.cbi.2014.04.006
Olas B. Hydrogen Sulfide in Hemostasis: Friend or Foe. Chem Biol Interact. 2014 Jun 25;217:49-56. PubMed PMID: 24746521.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hydrogen sulfide in hemostasis: friend or foe? A1 - Olas,Beata, Y1 - 2014/04/16/ PY - 2013/11/12/received PY - 2014/04/02/revised PY - 2014/04/06/accepted PY - 2014/4/22/entrez PY - 2014/4/22/pubmed PY - 2014/7/2/medline KW - Blood platelet activation KW - Cardiovascular system KW - Hemostasis KW - Hydrogen sulfide SP - 49 EP - 56 JF - Chemico-biological interactions JO - Chem Biol Interact VL - 217 N2 - Hydrogen sulfide (H2S) is a well known toxic gas that is synthesized from the amino acids: cysteine (Cys) and homocysteine (Hcy) by three enzymes: cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE) and mercaptopyruvate sulfurtransferase (3-MST). Hydrogen sulfide, like carbon monoxide (CO) or nitric oxide (NO) is a signaling molecule in different biological systems, including the cardiovascular system. Moreover, hydrogen sulfide plays a role in the pathogenesis of various cardiovascular diseases. It modulates different elements of hemostasis (activation of blood platelet, and coagulation process) as well as proliferation and apoptosis of vascular smooth muscle cells. However, the biological role and the therapeutic potential of H2S is not clear. This review summarizes the different functions of hydrogen sulfide in hemostasis. SN - 1872-7786 UR - https://www.unboundmedicine.com/medline/citation/24746521/Hydrogen_sulfide_in_hemostasis:_friend_or_foe L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-2797(14)00123-9 DB - PRIME DP - Unbound Medicine ER -