Tags

Type your tag names separated by a space and hit enter

Beyond genetics. Influence of dietary factors and gut microbiota on type 1 diabetes.
FEBS Lett. 2014 Nov 17; 588(22):4234-43.FL

Abstract

Type 1 diabetes (T1D) is an autoimmune disease ultimately leading to destruction of insulin secreting β-cells in the pancreas. Genetic susceptibility plays an important role in T1D etiology, but even mono-zygotic twins only have a concordance rate of around 50%, underlining that other factors than purely genetic are involved in disease development. Here we review the influence of dietary and environmental factors on T1D development in humans as well as animal models. Even though data are still inconclusive, there are strong indications that gut microbiota dysbiosis plays an important role in T1D development and evidence from animal models suggests that gut microbiota manipulation might prove valuable in future prevention of T1D in genetically susceptible individuals.

Authors+Show Affiliations

Department of Food Science, Faculty of Science, University of Copenhagen, 1958 Frederiksberg C, Denmark. Electronic address: dn@food.ku.dk.Department of Food Science, Faculty of Science, University of Copenhagen, 1958 Frederiksberg C, Denmark.Bartholin Institute, Rigshospitalet, 2100 Copenhagen, Denmark.Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, 1871 Frederiksberg C, Denmark.Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, 1871 Frederiksberg C, Denmark.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24746688

Citation

Nielsen, Dennis S., et al. "Beyond Genetics. Influence of Dietary Factors and Gut Microbiota On Type 1 Diabetes." FEBS Letters, vol. 588, no. 22, 2014, pp. 4234-43.
Nielsen DS, Krych Ł, Buschard K, et al. Beyond genetics. Influence of dietary factors and gut microbiota on type 1 diabetes. FEBS Lett. 2014;588(22):4234-43.
Nielsen, D. S., Krych, Ł., Buschard, K., Hansen, C. H., & Hansen, A. K. (2014). Beyond genetics. Influence of dietary factors and gut microbiota on type 1 diabetes. FEBS Letters, 588(22), 4234-43. https://doi.org/10.1016/j.febslet.2014.04.010
Nielsen DS, et al. Beyond Genetics. Influence of Dietary Factors and Gut Microbiota On Type 1 Diabetes. FEBS Lett. 2014 Nov 17;588(22):4234-43. PubMed PMID: 24746688.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Beyond genetics. Influence of dietary factors and gut microbiota on type 1 diabetes. AU - Nielsen,Dennis S, AU - Krych,Łukasz, AU - Buschard,Karsten, AU - Hansen,Camilla H F, AU - Hansen,Axel K, Y1 - 2014/04/18/ PY - 2014/02/24/received PY - 2014/04/04/revised PY - 2014/04/07/accepted PY - 2014/4/22/entrez PY - 2014/4/22/pubmed PY - 2015/1/22/medline KW - Diet KW - Etiology KW - Gut microbiota KW - Type 1 diabetes SP - 4234 EP - 43 JF - FEBS letters JO - FEBS Lett. VL - 588 IS - 22 N2 - Type 1 diabetes (T1D) is an autoimmune disease ultimately leading to destruction of insulin secreting β-cells in the pancreas. Genetic susceptibility plays an important role in T1D etiology, but even mono-zygotic twins only have a concordance rate of around 50%, underlining that other factors than purely genetic are involved in disease development. Here we review the influence of dietary and environmental factors on T1D development in humans as well as animal models. Even though data are still inconclusive, there are strong indications that gut microbiota dysbiosis plays an important role in T1D development and evidence from animal models suggests that gut microbiota manipulation might prove valuable in future prevention of T1D in genetically susceptible individuals. SN - 1873-3468 UR - https://www.unboundmedicine.com/medline/citation/24746688/Beyond_genetics__Influence_of_dietary_factors_and_gut_microbiota_on_type_1_diabetes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-5793(14)00296-8 DB - PRIME DP - Unbound Medicine ER -