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[The significance of oxidized DJ-1 protein (oxDJ-1) as a biomarker for Parkinson's disease].
Brain Nerve. 2014 Apr; 66(4):471-7.BN

Abstract

The search for biomarkers of Parkinson's disease (PD) typically focuses on cerebrospinal fluid components, with very few reports on simple biomarkers identifiable by blood analysis. In this report, we determined the level of oxidized DJ-1 protein (oxDJ-1) in red blood cells by ELISA and examined the association with MIBG myocardial scintigraphy. Levels of oxDJ-1 were higher in unmedicated patients with PD (142.2 ± 21.8 ng oxDJ-1/mg protein; n = 13) compared to the L-DOPA-treated group (85.6 ± 10.1 ng oxDJ-1/mg protein; n = 10) and controls (56.0 ± 6.2 ng oxDJ-1/mg protein; n = 17), thereby showing significant intergroup differences. Intervention with L-DOPA showed a tendency to decrease oxDJ-1 levels in patients. The diagnostic sensitivity of oxDJ-1 measurement was 87% and that of simultaneously conducted MIBG scintigraphy was 89%; this showed that the diagnostic sensitivity was comparable. Our results showed that measurement of oxDJ-1 levels in red blood cells can be useful and oxDJ-1 can be used as a biomarker for the early diagnosis of PD. (Receieved July 31, 2013; Accepted October 16, 2013; Published April 1, 2014).

Authors+Show Affiliations

Department of Neurology, Kinki University Faculty of Medicine.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

jpn

PubMed ID

24748095

Citation

Ogawa, Ikuko, et al. "[The Significance of Oxidized DJ-1 Protein (oxDJ-1) as a Biomarker for Parkinson's Disease]." Brain and Nerve = Shinkei Kenkyu No Shinpo, vol. 66, no. 4, 2014, pp. 471-7.
Ogawa I, Saito Y, Saigoh K, et al. [The significance of oxidized DJ-1 protein (oxDJ-1) as a biomarker for Parkinson's disease]. Brain Nerve. 2014;66(4):471-7.
Ogawa, I., Saito, Y., Saigoh, K., Hosoi, Y., Mitsui, Y., Noguchi, N., & Kusunoki, S. (2014). [The significance of oxidized DJ-1 protein (oxDJ-1) as a biomarker for Parkinson's disease]. Brain and Nerve = Shinkei Kenkyu No Shinpo, 66(4), 471-7.
Ogawa I, et al. [The Significance of Oxidized DJ-1 Protein (oxDJ-1) as a Biomarker for Parkinson's Disease]. Brain Nerve. 2014;66(4):471-7. PubMed PMID: 24748095.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The significance of oxidized DJ-1 protein (oxDJ-1) as a biomarker for Parkinson's disease]. AU - Ogawa,Ikuko, AU - Saito,Yoshiro, AU - Saigoh,Kazumasa, AU - Hosoi,Yoshie, AU - Mitsui,Yoshiyuki, AU - Noguchi,Noriko, AU - Kusunoki,Susumu, PY - 2014/4/22/entrez PY - 2014/4/22/pubmed PY - 2014/8/16/medline SP - 471 EP - 7 JF - Brain and nerve = Shinkei kenkyu no shinpo JO - Brain Nerve VL - 66 IS - 4 N2 - The search for biomarkers of Parkinson's disease (PD) typically focuses on cerebrospinal fluid components, with very few reports on simple biomarkers identifiable by blood analysis. In this report, we determined the level of oxidized DJ-1 protein (oxDJ-1) in red blood cells by ELISA and examined the association with MIBG myocardial scintigraphy. Levels of oxDJ-1 were higher in unmedicated patients with PD (142.2 ± 21.8 ng oxDJ-1/mg protein; n = 13) compared to the L-DOPA-treated group (85.6 ± 10.1 ng oxDJ-1/mg protein; n = 10) and controls (56.0 ± 6.2 ng oxDJ-1/mg protein; n = 17), thereby showing significant intergroup differences. Intervention with L-DOPA showed a tendency to decrease oxDJ-1 levels in patients. The diagnostic sensitivity of oxDJ-1 measurement was 87% and that of simultaneously conducted MIBG scintigraphy was 89%; this showed that the diagnostic sensitivity was comparable. Our results showed that measurement of oxDJ-1 levels in red blood cells can be useful and oxDJ-1 can be used as a biomarker for the early diagnosis of PD. (Receieved July 31, 2013; Accepted October 16, 2013; Published April 1, 2014). SN - 1881-6096 UR - https://www.unboundmedicine.com/medline/citation/24748095/[The_significance_of_oxidized_DJ_1_protein__oxDJ_1__as_a_biomarker_for_Parkinson's_disease]_ L2 - https://webview.isho.jp/openurl?rft.genre=article&rft.issn=1881-6096&rft.volume=66&rft.issue=4&rft.spage=471 DB - PRIME DP - Unbound Medicine ER -