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Assessment of trace elements in sera of patients undergoing renal dialysis.
Saudi Med J 2014; 35(4):365-70SM

Abstract

OBJECTIVE

To assess the serum levels of copper, zinc, iron, and lead in patients on maintenance dialysis.

METHODS

This cross-sectional study performed at King Khalid University Hospital, Riyadh, Saudi Arabia between September 2011 and October 2012 included 42 patients with end stage renal disease on hemodialysis (HD), 18 patients on peritoneal dialysis (PD), and 18 normal controls. Serum copper, zinc, and lead levels were determined by atomic absorption spectrophotometry, and serum iron was determined by spectrophotometric determination.

RESULTS

The median serum copper level in HD patients (20.5 nmol/L; 95% confidence interval [CI]: 17.52-22.39; interquartile range [IQR]: 16.40-24.20) was higher (p=0.001) than the controls (14.30 nmol/L; 95% CI: 9.72-16.91; IQR: 9.70-17), and the PD patients (15.60 nmol/L; 95% CI: 14.17-16.66; IQR: 14.10-16.70). Although no different from PD patients` serum levels of zinc in HD patients (9.50 nmol/L; 95% CI: 7.83-12.09; IQR: 7.00-14.40) were lower than controls (13.20 nmol/L; 95% CI: 10.65-15.22; IQR: 10.58-15.35; p=0.03). Copper/zinc ratio in HD patients was 2.4, 2.5 in PD patients, and 0.88 in controls. The serum iron levels in HD patients (10 mmol/L; 95% CI: 8.03-11.96; IQR: 7-14.50; p=0.003), and PD patients (10 mmol/L; 95% CI 6.56-14.43; IQR 5.50-15; p=0.03) were lower than controls. Serum lead levels in PD patients (0.11 umol/L; 95% CI: 0.02-0.14; IQR: 0.02-0.14) were lower than HD patients (0.18 umol/; 95% CI: 0.15-0.21; IQR: 0.13-0.25; p=0.005), and controls (0.15 umol/L; 95% CI: 0.07-0.24; IQR: 0.06-0.25; p=0.04).

CONCLUSION

Alterations in serum trace elements emphasize the need for monitoring trace elements in patients receiving maintenance dialysis.

Authors+Show Affiliations

Department of Pathology, College of Medicine and University Hospitals, King Saud University, Riyadh, Kingdom of Saudi Arabia. Tel. +966 (11) 4692697. Fax. +966 (11) 4672575. E-mail: ranamomen@yahoo.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24749133

Citation

Hasanato, Rana M.. "Assessment of Trace Elements in Sera of Patients Undergoing Renal Dialysis." Saudi Medical Journal, vol. 35, no. 4, 2014, pp. 365-70.
Hasanato RM. Assessment of trace elements in sera of patients undergoing renal dialysis. Saudi Med J. 2014;35(4):365-70.
Hasanato, R. M. (2014). Assessment of trace elements in sera of patients undergoing renal dialysis. Saudi Medical Journal, 35(4), pp. 365-70.
Hasanato RM. Assessment of Trace Elements in Sera of Patients Undergoing Renal Dialysis. Saudi Med J. 2014;35(4):365-70. PubMed PMID: 24749133.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of trace elements in sera of patients undergoing renal dialysis. A1 - Hasanato,Rana M, PY - 2014/4/22/entrez PY - 2014/4/22/pubmed PY - 2015/4/14/medline SP - 365 EP - 70 JF - Saudi medical journal JO - Saudi Med J VL - 35 IS - 4 N2 - OBJECTIVE: To assess the serum levels of copper, zinc, iron, and lead in patients on maintenance dialysis. METHODS: This cross-sectional study performed at King Khalid University Hospital, Riyadh, Saudi Arabia between September 2011 and October 2012 included 42 patients with end stage renal disease on hemodialysis (HD), 18 patients on peritoneal dialysis (PD), and 18 normal controls. Serum copper, zinc, and lead levels were determined by atomic absorption spectrophotometry, and serum iron was determined by spectrophotometric determination. RESULTS: The median serum copper level in HD patients (20.5 nmol/L; 95% confidence interval [CI]: 17.52-22.39; interquartile range [IQR]: 16.40-24.20) was higher (p=0.001) than the controls (14.30 nmol/L; 95% CI: 9.72-16.91; IQR: 9.70-17), and the PD patients (15.60 nmol/L; 95% CI: 14.17-16.66; IQR: 14.10-16.70). Although no different from PD patients` serum levels of zinc in HD patients (9.50 nmol/L; 95% CI: 7.83-12.09; IQR: 7.00-14.40) were lower than controls (13.20 nmol/L; 95% CI: 10.65-15.22; IQR: 10.58-15.35; p=0.03). Copper/zinc ratio in HD patients was 2.4, 2.5 in PD patients, and 0.88 in controls. The serum iron levels in HD patients (10 mmol/L; 95% CI: 8.03-11.96; IQR: 7-14.50; p=0.003), and PD patients (10 mmol/L; 95% CI 6.56-14.43; IQR 5.50-15; p=0.03) were lower than controls. Serum lead levels in PD patients (0.11 umol/L; 95% CI: 0.02-0.14; IQR: 0.02-0.14) were lower than HD patients (0.18 umol/; 95% CI: 0.15-0.21; IQR: 0.13-0.25; p=0.005), and controls (0.15 umol/L; 95% CI: 0.07-0.24; IQR: 0.06-0.25; p=0.04). CONCLUSION: Alterations in serum trace elements emphasize the need for monitoring trace elements in patients receiving maintenance dialysis. SN - 0379-5284 UR - https://www.unboundmedicine.com/medline/citation/24749133/Assessment_of_trace_elements_in_sera_of_patients_undergoing_renal_dialysis_ L2 - https://medlineplus.gov/dialysis.html DB - PRIME DP - Unbound Medicine ER -