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Different obesity phenotypes, and incident cardiovascular disease and mortality events in elderly Iranians: Tehran lipid and glucose study.
Geriatr Gerontol Int. 2015 Apr; 15(4):449-56.GG

Abstract

AIM

To determine the impact of body mass index and the presence of metabolic syndrome (MetS) on cardiovascular disease (CVD) and mortality events in an elderly Tehranian population.

METHODS

A population-based cohort of 1199 participants aged ≥65 years were followed for a mean of 9.74 years. Participants were stratified according to body mass index categories and MetS status. Cox regression analyses were used to estimate the hazard ratio of CVD and mortality events, given overweight participants without MetS as reference.

RESULT

During follow up, 271 CVD events and 239 deaths (106 CVD deaths) occurred. Regarding CVD, multivariate-adjusted hazard ratios for CVD events in normal weight and obese participants without MetS were 1.21 (95% CI 0.77-1.91) and 1.46 (95% CI 0.64-3.34), respectively, and for normal weight, overweight and obese participants with MetS were 2.07 (95% CI 1.23-3.28), 1.72 (95% CI 1.13-2.62), and 1.53 (95% CI 0.95-2.45), respectively. Corresponding hazard ratios for CVD mortality were 2.08 (95% CI 0.93-4.82), 1.07 (95% CI 0.13-8.78), 3.71 (95% CI 1.55-8.85), 2.42 (95% CI 1.06-5.51) and 3.31 (95% CI 1.39-7.88), and for all-cause mortality were 1.41 (95% CI 0.9-2.23), 1.33 (95% CI 0.51-3.47), 1.84 (95% CI 1.1-3.09), 1.46 (95% CI 0.93-2.34) and 1.5 (95% CI 0.91-2.56), respectively. In the presence of diabetes in place of MetS, all of the diabetic participants regardless of body mass index category highlighted a significant risk for CVD and mortality events.

CONCLUSION

Among the elderly population, the presence of MetS was necessary for exploring the risk of CVD events and its mortality; however, only the normal weight population with MetS had a significant risk for all-cause mortality

Authors+Show Affiliations

Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24750352

Citation

Mirbolouk, Mohammadhassan, et al. "Different Obesity Phenotypes, and Incident Cardiovascular Disease and Mortality Events in Elderly Iranians: Tehran Lipid and Glucose Study." Geriatrics & Gerontology International, vol. 15, no. 4, 2015, pp. 449-56.
Mirbolouk M, Asgari S, Sheikholeslami F, et al. Different obesity phenotypes, and incident cardiovascular disease and mortality events in elderly Iranians: Tehran lipid and glucose study. Geriatr Gerontol Int. 2015;15(4):449-56.
Mirbolouk, M., Asgari, S., Sheikholeslami, F., Mirbolouk, F., Azizi, F., & Hadaegh, F. (2015). Different obesity phenotypes, and incident cardiovascular disease and mortality events in elderly Iranians: Tehran lipid and glucose study. Geriatrics & Gerontology International, 15(4), 449-56. https://doi.org/10.1111/ggi.12295
Mirbolouk M, et al. Different Obesity Phenotypes, and Incident Cardiovascular Disease and Mortality Events in Elderly Iranians: Tehran Lipid and Glucose Study. Geriatr Gerontol Int. 2015;15(4):449-56. PubMed PMID: 24750352.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Different obesity phenotypes, and incident cardiovascular disease and mortality events in elderly Iranians: Tehran lipid and glucose study. AU - Mirbolouk,Mohammadhassan, AU - Asgari,Samaneh, AU - Sheikholeslami,Farhad, AU - Mirbolouk,Fardin, AU - Azizi,Fereidoun, AU - Hadaegh,Farzad, Y1 - 2014/04/21/ PY - 2014/03/09/accepted PY - 2014/4/23/entrez PY - 2014/4/23/pubmed PY - 2016/1/5/medline KW - aged KW - cardiovascular disease KW - metabolic syndrome X KW - obesity SP - 449 EP - 56 JF - Geriatrics & gerontology international JO - Geriatr Gerontol Int VL - 15 IS - 4 N2 - AIM: To determine the impact of body mass index and the presence of metabolic syndrome (MetS) on cardiovascular disease (CVD) and mortality events in an elderly Tehranian population. METHODS: A population-based cohort of 1199 participants aged ≥65 years were followed for a mean of 9.74 years. Participants were stratified according to body mass index categories and MetS status. Cox regression analyses were used to estimate the hazard ratio of CVD and mortality events, given overweight participants without MetS as reference. RESULT: During follow up, 271 CVD events and 239 deaths (106 CVD deaths) occurred. Regarding CVD, multivariate-adjusted hazard ratios for CVD events in normal weight and obese participants without MetS were 1.21 (95% CI 0.77-1.91) and 1.46 (95% CI 0.64-3.34), respectively, and for normal weight, overweight and obese participants with MetS were 2.07 (95% CI 1.23-3.28), 1.72 (95% CI 1.13-2.62), and 1.53 (95% CI 0.95-2.45), respectively. Corresponding hazard ratios for CVD mortality were 2.08 (95% CI 0.93-4.82), 1.07 (95% CI 0.13-8.78), 3.71 (95% CI 1.55-8.85), 2.42 (95% CI 1.06-5.51) and 3.31 (95% CI 1.39-7.88), and for all-cause mortality were 1.41 (95% CI 0.9-2.23), 1.33 (95% CI 0.51-3.47), 1.84 (95% CI 1.1-3.09), 1.46 (95% CI 0.93-2.34) and 1.5 (95% CI 0.91-2.56), respectively. In the presence of diabetes in place of MetS, all of the diabetic participants regardless of body mass index category highlighted a significant risk for CVD and mortality events. CONCLUSION: Among the elderly population, the presence of MetS was necessary for exploring the risk of CVD events and its mortality; however, only the normal weight population with MetS had a significant risk for all-cause mortality SN - 1447-0594 UR - https://www.unboundmedicine.com/medline/citation/24750352/Different_obesity_phenotypes_and_incident_cardiovascular_disease_and_mortality_events_in_elderly_Iranians:_Tehran_lipid_and_glucose_study_ L2 - https://doi.org/10.1111/ggi.12295 DB - PRIME DP - Unbound Medicine ER -