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Coffee consumption and the risk of latent autoimmune diabetes in adults--results from a Swedish case-control study.
Diabet Med 2014; 31(7):799-805DM

Abstract

AIMS

Coffee consumption is associated with a reduced risk of Type 2 diabetes. Our aim was to investigate if coffee intake may also reduce the risk of latent autoimmune diabetes in adults, an autoimmune form of diabetes with features of Type 2 diabetes.

METHODS

We used data from a population-based case-control study with incident cases of adult onset (≥ 35 years) diabetes, including 245 cases of latent autoimmune diabetes in adults (glutamic acid decarboxylase antibody positive), 759 cases of Type 2 diabetes (glutamic acid decarboxylase antibody negative), together with 990 control subjects without diabetes, randomly selected from the population. Using questionnaire information on coffee consumption, we estimated the odds ratio of latent autoimmune diabetes in adults and Type 2 diabetes adjusted for age, sex, BMI, smoking, physical activity, alcohol, education and family history of diabetes.

RESULTS

Coffee intake was inversely associated with Type 2 diabetes (odds ratio 0.92, 95% CI 0.87-0.98 per cup/day). With regard to latent autoimmune diabetes in adults, the general trend was weak (odds ratio 1.04, 95% CI 0.96-1.13), but stratification by degree of autoimmunity (median glutamic acid decarboxylase antibody levels) suggested that coffee intake may be associated with an increased risk of high glutamic acid decarboxylase antibody latent autoimmune diabetes in adults (odds ratio 1.11, 95% CI 1.00-1.23 per cup/day). Furthermore, for every additional cup of coffee consumed per day, there was a 15.2% (P = 0.0268) increase in glutamic acid decarboxylase antibody levels.

CONCLUSIONS

Our findings confirm that coffee consumption is associated with a reduced risk of Type 2 diabetes. Interestingly, the findings suggest that coffee may be associated with development of autoimmunity and possibly an increased risk of more Type 1-like latent autoimmune diabetes in adults.

Authors+Show Affiliations

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24750356

Citation

Löfvenborg, J E., et al. "Coffee Consumption and the Risk of Latent Autoimmune Diabetes in Adults--results From a Swedish Case-control Study." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 31, no. 7, 2014, pp. 799-805.
Löfvenborg JE, Andersson T, Carlsson PO, et al. Coffee consumption and the risk of latent autoimmune diabetes in adults--results from a Swedish case-control study. Diabet Med. 2014;31(7):799-805.
Löfvenborg, J. E., Andersson, T., Carlsson, P. O., Dorkhan, M., Groop, L., Martinell, M., ... Carlsson, S. (2014). Coffee consumption and the risk of latent autoimmune diabetes in adults--results from a Swedish case-control study. Diabetic Medicine : a Journal of the British Diabetic Association, 31(7), pp. 799-805. doi:10.1111/dme.12469.
Löfvenborg JE, et al. Coffee Consumption and the Risk of Latent Autoimmune Diabetes in Adults--results From a Swedish Case-control Study. Diabet Med. 2014;31(7):799-805. PubMed PMID: 24750356.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coffee consumption and the risk of latent autoimmune diabetes in adults--results from a Swedish case-control study. AU - Löfvenborg,J E, AU - Andersson,T, AU - Carlsson,P-O, AU - Dorkhan,M, AU - Groop,L, AU - Martinell,M, AU - Rasouli,B, AU - Storm,P, AU - Tuomi,T, AU - Carlsson,S, Y1 - 2014/05/02/ PY - 2013/11/21/received PY - 2014/01/22/revised PY - 2014/04/10/accepted PY - 2014/4/23/entrez PY - 2014/4/23/pubmed PY - 2015/3/31/medline SP - 799 EP - 805 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet. Med. VL - 31 IS - 7 N2 - AIMS: Coffee consumption is associated with a reduced risk of Type 2 diabetes. Our aim was to investigate if coffee intake may also reduce the risk of latent autoimmune diabetes in adults, an autoimmune form of diabetes with features of Type 2 diabetes. METHODS: We used data from a population-based case-control study with incident cases of adult onset (≥ 35 years) diabetes, including 245 cases of latent autoimmune diabetes in adults (glutamic acid decarboxylase antibody positive), 759 cases of Type 2 diabetes (glutamic acid decarboxylase antibody negative), together with 990 control subjects without diabetes, randomly selected from the population. Using questionnaire information on coffee consumption, we estimated the odds ratio of latent autoimmune diabetes in adults and Type 2 diabetes adjusted for age, sex, BMI, smoking, physical activity, alcohol, education and family history of diabetes. RESULTS: Coffee intake was inversely associated with Type 2 diabetes (odds ratio 0.92, 95% CI 0.87-0.98 per cup/day). With regard to latent autoimmune diabetes in adults, the general trend was weak (odds ratio 1.04, 95% CI 0.96-1.13), but stratification by degree of autoimmunity (median glutamic acid decarboxylase antibody levels) suggested that coffee intake may be associated with an increased risk of high glutamic acid decarboxylase antibody latent autoimmune diabetes in adults (odds ratio 1.11, 95% CI 1.00-1.23 per cup/day). Furthermore, for every additional cup of coffee consumed per day, there was a 15.2% (P = 0.0268) increase in glutamic acid decarboxylase antibody levels. CONCLUSIONS: Our findings confirm that coffee consumption is associated with a reduced risk of Type 2 diabetes. Interestingly, the findings suggest that coffee may be associated with development of autoimmunity and possibly an increased risk of more Type 1-like latent autoimmune diabetes in adults. SN - 1464-5491 UR - https://www.unboundmedicine.com/medline/citation/24750356/Coffee_consumption_and_the_risk_of_latent_autoimmune_diabetes_in_adults__results_from_a_Swedish_case_control_study_ L2 - https://doi.org/10.1111/dme.12469 DB - PRIME DP - Unbound Medicine ER -