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Reassortant swine influenza viruses isolated in Japan contain genes from pandemic A(H1N1) 2009.
Microbiol Immunol 2014; 58(6):327-41MI

Abstract

In 2013, three reassortant swine influenza viruses (SIVs)-two H1N2 and one H3N2-were isolated from symptomatic pigs in Japan; each contained genes from the pandemic A(H1N1) 2009 virus and endemic SIVs. Phylogenetic analysis revealed that the two H1N2 viruses, A/swine/Gunma/1/2013 and A/swine/Ibaraki/1/2013, were reassortants that contain genes from the following three distinct lineages: (i) H1 and nucleoprotein (NP) genes derived from a classical swine H1 HA lineage uniquely circulating among Japanese SIVs; (ii) neuraminidase (NA) genes from human-like H1N2 swine viruses; and (iii) other genes from pandemic A(H1N1) 2009 viruses. The H3N2 virus, A/swine/Miyazaki/2/2013, comprised genes from two sources: (i) hemagglutinin (HA) and NA genes derived from human and human-like H3N2 swine viruses and (ii) other genes from pandemic A(H1N1) 2009 viruses. Phylogenetic analysis also indicated that each of the reassortants may have arisen independently in Japanese pigs. A/swine/Miyazaki/2/2013 were found to have strong antigenic reactivities with antisera generated for some seasonal human-lineage viruses isolated during or before 2003, whereas A/swine/Miyazaki/2/2013 reactivities with antisera against viruses isolated after 2004 were clearly weaker. In addition, antisera against some strains of seasonal human-lineage H1 viruses did not react with either A/swine/Gunma/1/2013 or A/swine/Ibaraki/1/2013. These findings indicate that emergence and spread of these reassortant SIVs is a potential public health risk.

Authors+Show Affiliations

Influenza and Prion Disease Research Center, National Institute of Animal Health, National Agriculture and Food Research Organization (NARO), 3-1-5 Kannondai, Tsukuba, Ibaraki, 305-0856, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24750464

Citation

Kanehira, Katsushi, et al. "Reassortant Swine Influenza Viruses Isolated in Japan Contain Genes From Pandemic A(H1N1) 2009." Microbiology and Immunology, vol. 58, no. 6, 2014, pp. 327-41.
Kanehira K, Takemae N, Uchida Y, et al. Reassortant swine influenza viruses isolated in Japan contain genes from pandemic A(H1N1) 2009. Microbiol Immunol. 2014;58(6):327-41.
Kanehira, K., Takemae, N., Uchida, Y., Hikono, H., & Saito, T. (2014). Reassortant swine influenza viruses isolated in Japan contain genes from pandemic A(H1N1) 2009. Microbiology and Immunology, 58(6), pp. 327-41. doi:10.1111/1348-0421.12152.
Kanehira K, et al. Reassortant Swine Influenza Viruses Isolated in Japan Contain Genes From Pandemic A(H1N1) 2009. Microbiol Immunol. 2014;58(6):327-41. PubMed PMID: 24750464.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reassortant swine influenza viruses isolated in Japan contain genes from pandemic A(H1N1) 2009. AU - Kanehira,Katsushi, AU - Takemae,Nobuhiro, AU - Uchida,Yuko, AU - Hikono,Hirokazu, AU - Saito,Takehiko, PY - 2014/02/13/received PY - 2014/04/03/revised PY - 2014/04/14/accepted PY - 2014/4/23/entrez PY - 2014/4/23/pubmed PY - 2015/1/23/medline KW - pandemic A(H1N1) 2009 KW - reassortant influenza virus KW - swine influenza virus SP - 327 EP - 41 JF - Microbiology and immunology JO - Microbiol. Immunol. VL - 58 IS - 6 N2 - In 2013, three reassortant swine influenza viruses (SIVs)-two H1N2 and one H3N2-were isolated from symptomatic pigs in Japan; each contained genes from the pandemic A(H1N1) 2009 virus and endemic SIVs. Phylogenetic analysis revealed that the two H1N2 viruses, A/swine/Gunma/1/2013 and A/swine/Ibaraki/1/2013, were reassortants that contain genes from the following three distinct lineages: (i) H1 and nucleoprotein (NP) genes derived from a classical swine H1 HA lineage uniquely circulating among Japanese SIVs; (ii) neuraminidase (NA) genes from human-like H1N2 swine viruses; and (iii) other genes from pandemic A(H1N1) 2009 viruses. The H3N2 virus, A/swine/Miyazaki/2/2013, comprised genes from two sources: (i) hemagglutinin (HA) and NA genes derived from human and human-like H3N2 swine viruses and (ii) other genes from pandemic A(H1N1) 2009 viruses. Phylogenetic analysis also indicated that each of the reassortants may have arisen independently in Japanese pigs. A/swine/Miyazaki/2/2013 were found to have strong antigenic reactivities with antisera generated for some seasonal human-lineage viruses isolated during or before 2003, whereas A/swine/Miyazaki/2/2013 reactivities with antisera against viruses isolated after 2004 were clearly weaker. In addition, antisera against some strains of seasonal human-lineage H1 viruses did not react with either A/swine/Gunma/1/2013 or A/swine/Ibaraki/1/2013. These findings indicate that emergence and spread of these reassortant SIVs is a potential public health risk. SN - 1348-0421 UR - https://www.unboundmedicine.com/medline/citation/24750464/Reassortant_swine_influenza_viruses_isolated_in_Japan_contain_genes_from_pandemic_A_H1N1__2009_ L2 - https://doi.org/10.1111/1348-0421.12152 DB - PRIME DP - Unbound Medicine ER -