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Fast and long-acting antibacterial properties of chitosan-Ag/polyvinylpyrrolidone nanocomposite films.
Carbohydr Polym. 2012 Sep 01; 90(1):8-15.CP

Abstract

Infection associated with medical devices is one of the most frequent complications of modern medical biomaterials. Preparation of antibacterial films on the medical devices is a great challenge owing to bactericidal efficiency, long acting and biocompatibility. In this study, silver nanoparticles (Ag NPs) doped chitosan/polyvinylpyrrolidone (PVP) films were successfully prepared by dip coating method. The nanocomposite films with spherical Ag NPs (diameters in 10-50 nm) were stable after being immersed in PBS for 35 days. Through regulating the concentration of AgNO3, the nanocomposite films showed good cell compatibility. The nanocomposite films could eliminate 100% Staphylococcus aureus (ATCC 6538) and Escherichia coli (ATCC 8739) in 5 min and had favorable long-acting antibacterial property. The increase of PVP amount obviously enhanced anti-adhesion activity of the nanocomposite film. Such nanocomposite films can be expected to have good potential in biomaterials applications.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Wang BL
MOE Key Laboratory of Macromolecule Synthesis and functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
Liu XS
No affiliation info available
Ji Y
No affiliation info available
Ren KF
No affiliation info available
Ji J
No affiliation info available

MeSH

Anti-Bacterial AgentsBiocompatible MaterialsChitosanEscherichia coliEscherichia coli InfectionsHumansMetal NanoparticlesMicrobial Sensitivity TestsNanocompositesPovidoneSilverStaphylococcal InfectionsStaphylococcus aureus

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24751004

Citation

Wang, Bai-Liang, et al. "Fast and Long-acting Antibacterial Properties of chitosan-Ag/polyvinylpyrrolidone Nanocomposite Films." Carbohydrate Polymers, vol. 90, no. 1, 2012, pp. 8-15.
Wang BL, Liu XS, Ji Y, et al. Fast and long-acting antibacterial properties of chitosan-Ag/polyvinylpyrrolidone nanocomposite films. Carbohydr Polym. 2012;90(1):8-15.
Wang, B. L., Liu, X. S., Ji, Y., Ren, K. F., & Ji, J. (2012). Fast and long-acting antibacterial properties of chitosan-Ag/polyvinylpyrrolidone nanocomposite films. Carbohydrate Polymers, 90(1), 8-15. https://doi.org/10.1016/j.carbpol.2012.03.080
Wang BL, et al. Fast and Long-acting Antibacterial Properties of chitosan-Ag/polyvinylpyrrolidone Nanocomposite Films. Carbohydr Polym. 2012 Sep 1;90(1):8-15. PubMed PMID: 24751004.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fast and long-acting antibacterial properties of chitosan-Ag/polyvinylpyrrolidone nanocomposite films. AU - Wang,Bai-Liang, AU - Liu,Xiang-Sheng, AU - Ji,Ying, AU - Ren,Ke-Feng, AU - Ji,Jian, Y1 - 2012/04/01/ PY - 2011/12/16/received PY - 2012/03/22/revised PY - 2012/03/24/accepted PY - 2014/4/23/entrez PY - 2012/9/1/pubmed PY - 2015/10/16/medline SP - 8 EP - 15 JF - Carbohydrate polymers JO - Carbohydr Polym VL - 90 IS - 1 N2 - Infection associated with medical devices is one of the most frequent complications of modern medical biomaterials. Preparation of antibacterial films on the medical devices is a great challenge owing to bactericidal efficiency, long acting and biocompatibility. In this study, silver nanoparticles (Ag NPs) doped chitosan/polyvinylpyrrolidone (PVP) films were successfully prepared by dip coating method. The nanocomposite films with spherical Ag NPs (diameters in 10-50 nm) were stable after being immersed in PBS for 35 days. Through regulating the concentration of AgNO3, the nanocomposite films showed good cell compatibility. The nanocomposite films could eliminate 100% Staphylococcus aureus (ATCC 6538) and Escherichia coli (ATCC 8739) in 5 min and had favorable long-acting antibacterial property. The increase of PVP amount obviously enhanced anti-adhesion activity of the nanocomposite film. Such nanocomposite films can be expected to have good potential in biomaterials applications. SN - 1879-1344 UR - https://www.unboundmedicine.com/medline/citation/24751004/Fast_and_long_acting_antibacterial_properties_of_chitosan_Ag/polyvinylpyrrolidone_nanocomposite_films_ DB - PRIME DP - Unbound Medicine ER -