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Albizia procera gum as an excipient for oral controlled release matrix tablet.
Carbohydr Polym. 2012 Sep 01; 90(1):289-95.CP

Abstract

The purpose of this research was to develop and evaluate controlled release matrix tablets of paracetamol based on natural gum exudates of Albizia procera. Procera gum was characterized of its properties like compressibility index, angle of repose, viscosity and moisture content. The interaction between the gum and paracetamol was also studied through differential scanning calorimetry (DSC) and FTIR spectroscopy. Matrix tablets were then prepared by wet granulation method with different concentrations of procera gum and hydroxypropyl methylcellulose (HPMC) and evaluated for their physical properties like weight variation, hardness, friability and content uniformity. Dissolution study was conducted to characterize release mechanism from the matrix system and data were fitted to various kinetic models. The mechanism of drug release from both types of matrix tablets was found to be anomalous type. Results from various evaluations suggested that A. procera gum could be used as drug release retardant in controlled release matrix systems.

Authors+Show Affiliations

Department of Pharmacy, Regional Institute of Paramedical & Nursing Sciences (RIPANS), Aizawl 796017, Mizoram, India.Department of Pharmaceutical Sciences, Dibrugarh University, 786004, Assam, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24751043

Citation

Pachuau, Lalduhsanga, and Bhaskar Mazumder. "Albizia Procera Gum as an Excipient for Oral Controlled Release Matrix Tablet." Carbohydrate Polymers, vol. 90, no. 1, 2012, pp. 289-95.
Pachuau L, Mazumder B. Albizia procera gum as an excipient for oral controlled release matrix tablet. Carbohydr Polym. 2012;90(1):289-95.
Pachuau, L., & Mazumder, B. (2012). Albizia procera gum as an excipient for oral controlled release matrix tablet. Carbohydrate Polymers, 90(1), 289-95. https://doi.org/10.1016/j.carbpol.2012.05.038
Pachuau L, Mazumder B. Albizia Procera Gum as an Excipient for Oral Controlled Release Matrix Tablet. Carbohydr Polym. 2012 Sep 1;90(1):289-95. PubMed PMID: 24751043.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Albizia procera gum as an excipient for oral controlled release matrix tablet. AU - Pachuau,Lalduhsanga, AU - Mazumder,Bhaskar, Y1 - 2012/05/22/ PY - 2012/04/08/received PY - 2012/05/02/revised PY - 2012/05/15/accepted PY - 2014/4/23/entrez PY - 2012/9/1/pubmed PY - 2015/10/17/medline SP - 289 EP - 95 JF - Carbohydrate polymers JO - Carbohydr Polym VL - 90 IS - 1 N2 - The purpose of this research was to develop and evaluate controlled release matrix tablets of paracetamol based on natural gum exudates of Albizia procera. Procera gum was characterized of its properties like compressibility index, angle of repose, viscosity and moisture content. The interaction between the gum and paracetamol was also studied through differential scanning calorimetry (DSC) and FTIR spectroscopy. Matrix tablets were then prepared by wet granulation method with different concentrations of procera gum and hydroxypropyl methylcellulose (HPMC) and evaluated for their physical properties like weight variation, hardness, friability and content uniformity. Dissolution study was conducted to characterize release mechanism from the matrix system and data were fitted to various kinetic models. The mechanism of drug release from both types of matrix tablets was found to be anomalous type. Results from various evaluations suggested that A. procera gum could be used as drug release retardant in controlled release matrix systems. SN - 1879-1344 UR - https://www.unboundmedicine.com/medline/citation/24751043/Albizia_procera_gum_as_an_excipient_for_oral_controlled_release_matrix_tablet_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0144-8617(12)00460-2 DB - PRIME DP - Unbound Medicine ER -