Tags

Type your tag names separated by a space and hit enter

Protective effects of blueberries (Vaccinium corymbosum L.) extract against cadmium-induced hepatotoxicity in mice.
Environ Toxicol Pharmacol. 2014 May; 37(3):1015-27.ET

Abstract

The oxidative status and morphological changes of mouse liver exposed to cadmium chloride (Cd(II)) and therapeutic potential of blueberry (Vaccinium corymbosum L.) extract against Cd(II)-induced hepatic injury were investigated. A variety of parameters were evaluated, including lipid peroxidation (LPO), protein carbonyl (PCO) level, DNA fragment, as well as antioxidative defense system (i.e., superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH)). Elemental analysis and evaluation of morphological changes and NO levels were also performed. Exposure to Cd(II) led to increased LPO and PCO as well as DNA fragment and a reduction of SOD and CAT activities, however, the content of GSH elevated probably due to biological adaptive-response. In contrast, co-treatment of anthocyanin (Ay) inhibited the increased oxidative parameters as well as restored the activities of antioxidative defense system in a dose-dependent manner. Ay administration regained these morphological changes caused by intoxication of Cd(II) to nearly normal levels. Moreover, the accumulation of Cd(II) in liver may be one of the reasons for Cd(II) toxicity and Ay can chelate with Cd(II) to reduce Cd(II) burden. The influence of Cd(II) on the Zn and Ca levels can also be adjusted by the co-administration of Ay. Exposure to Cd(II) led to an increase of NO and Ay reduced NO contents probably by directly scavenging. Potential mechanisms for the protective effect of Ay have been proposed, including its anti-oxidative and anti-inflammatory effect along with the metal-chelating capacity. These results suggest that blueberry extract may be valuable as a therapeutic agent in combating Cd(II)-induced tissue injury.

Authors+Show Affiliations

College of Life Science and Technology, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China. Electronic address: lavenderpin@gmail.com.School of Chemistry and Chemical Engineering, Xi'an University of Science and Technology, Xi'an 710054, China.College of Life Science and Technology, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.College of Life Science and Technology, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.College of Life Science and Technology, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.College of Life Science and Technology, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24751684

Citation

Gong, Pin, et al. "Protective Effects of Blueberries (Vaccinium Corymbosum L.) Extract Against Cadmium-induced Hepatotoxicity in Mice." Environmental Toxicology and Pharmacology, vol. 37, no. 3, 2014, pp. 1015-27.
Gong P, Chen FX, Wang L, et al. Protective effects of blueberries (Vaccinium corymbosum L.) extract against cadmium-induced hepatotoxicity in mice. Environ Toxicol Pharmacol. 2014;37(3):1015-27.
Gong, P., Chen, F. X., Wang, L., Wang, J., Jin, S., & Ma, Y. M. (2014). Protective effects of blueberries (Vaccinium corymbosum L.) extract against cadmium-induced hepatotoxicity in mice. Environmental Toxicology and Pharmacology, 37(3), 1015-27. https://doi.org/10.1016/j.etap.2014.03.017
Gong P, et al. Protective Effects of Blueberries (Vaccinium Corymbosum L.) Extract Against Cadmium-induced Hepatotoxicity in Mice. Environ Toxicol Pharmacol. 2014;37(3):1015-27. PubMed PMID: 24751684.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effects of blueberries (Vaccinium corymbosum L.) extract against cadmium-induced hepatotoxicity in mice. AU - Gong,Pin, AU - Chen,Fu-xin, AU - Wang,Lan, AU - Wang,Jing, AU - Jin,Sai, AU - Ma,Yang-min, Y1 - 2014/03/30/ PY - 2013/11/26/received PY - 2014/03/18/revised PY - 2014/03/23/accepted PY - 2014/4/23/entrez PY - 2014/4/23/pubmed PY - 2015/1/30/medline KW - Anthocyanin KW - Blueberry KW - Cadmium KW - Hepatotoxicity KW - Oxidative stress SP - 1015 EP - 27 JF - Environmental toxicology and pharmacology JO - Environ Toxicol Pharmacol VL - 37 IS - 3 N2 - The oxidative status and morphological changes of mouse liver exposed to cadmium chloride (Cd(II)) and therapeutic potential of blueberry (Vaccinium corymbosum L.) extract against Cd(II)-induced hepatic injury were investigated. A variety of parameters were evaluated, including lipid peroxidation (LPO), protein carbonyl (PCO) level, DNA fragment, as well as antioxidative defense system (i.e., superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH)). Elemental analysis and evaluation of morphological changes and NO levels were also performed. Exposure to Cd(II) led to increased LPO and PCO as well as DNA fragment and a reduction of SOD and CAT activities, however, the content of GSH elevated probably due to biological adaptive-response. In contrast, co-treatment of anthocyanin (Ay) inhibited the increased oxidative parameters as well as restored the activities of antioxidative defense system in a dose-dependent manner. Ay administration regained these morphological changes caused by intoxication of Cd(II) to nearly normal levels. Moreover, the accumulation of Cd(II) in liver may be one of the reasons for Cd(II) toxicity and Ay can chelate with Cd(II) to reduce Cd(II) burden. The influence of Cd(II) on the Zn and Ca levels can also be adjusted by the co-administration of Ay. Exposure to Cd(II) led to an increase of NO and Ay reduced NO contents probably by directly scavenging. Potential mechanisms for the protective effect of Ay have been proposed, including its anti-oxidative and anti-inflammatory effect along with the metal-chelating capacity. These results suggest that blueberry extract may be valuable as a therapeutic agent in combating Cd(II)-induced tissue injury. SN - 1872-7077 UR - https://www.unboundmedicine.com/medline/citation/24751684/Protective_effects_of_blueberries__Vaccinium_corymbosum_L___extract_against_cadmium_induced_hepatotoxicity_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1382-6689(14)00072-6 DB - PRIME DP - Unbound Medicine ER -