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Leg ulcers in patients with sickle cell disease.
Blood 1989; 74(4):1403-8Blood

Abstract

During the entry examination, leg ulcers were present in 2.5% of 2,075 patients 10 years of age and older with sickle cell disease who entered into the Cooperative Study of Sickle Cell Disease (CSSCD) between 1979 and 1986. Prevalence rates were highest among patients with sickle cell anemia and sickle cell anemia with thalassemia genotypes. Among sickle cell anemia patients free of ulcers at entry, the overall incidence was 5.73 per 100 person years in those having associated alpha-thalassemia and 9.97 for those without. Among sickle cell anemia patients with two alpha genes, the estimated incidence of leg ulcers is 2.38 per 100 person years and 6.12 per 100 person years among sickle cell anemia patients with three alpha genes (P less than .05). In both groups, the incidence was highest among those patients over 20 years of age and considerably higher among males than females (P less than .001). Leg ulcers were nonexistent in patients with sickle beta plus thalassemia and sickle hemoglobin C disease. Low steady-state hemoglobin is associated with a higher incidence of ulcer formation (P less than .0001) in sickle cell anemia patients. The protective effect of hemoglobin F is apparent at all levels of total hemoglobin among sickle cell anemia patients and those with associated alpha-thalassemia.

Authors+Show Affiliations

Department of Medicine, University of Illinois, Chicago 60612.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2475188

Citation

Koshy, M, et al. "Leg Ulcers in Patients With Sickle Cell Disease." Blood, vol. 74, no. 4, 1989, pp. 1403-8.
Koshy M, Entsuah R, Koranda A, et al. Leg ulcers in patients with sickle cell disease. Blood. 1989;74(4):1403-8.
Koshy, M., Entsuah, R., Koranda, A., Kraus, A. P., Johnson, R., Bellvue, R., ... Levy, P. (1989). Leg ulcers in patients with sickle cell disease. Blood, 74(4), pp. 1403-8.
Koshy M, et al. Leg Ulcers in Patients With Sickle Cell Disease. Blood. 1989;74(4):1403-8. PubMed PMID: 2475188.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Leg ulcers in patients with sickle cell disease. AU - Koshy,M, AU - Entsuah,R, AU - Koranda,A, AU - Kraus,A P, AU - Johnson,R, AU - Bellvue,R, AU - Flournoy-Gill,Z, AU - Levy,P, PY - 1989/9/1/pubmed PY - 1989/9/1/medline PY - 1989/9/1/entrez SP - 1403 EP - 8 JF - Blood JO - Blood VL - 74 IS - 4 N2 - During the entry examination, leg ulcers were present in 2.5% of 2,075 patients 10 years of age and older with sickle cell disease who entered into the Cooperative Study of Sickle Cell Disease (CSSCD) between 1979 and 1986. Prevalence rates were highest among patients with sickle cell anemia and sickle cell anemia with thalassemia genotypes. Among sickle cell anemia patients free of ulcers at entry, the overall incidence was 5.73 per 100 person years in those having associated alpha-thalassemia and 9.97 for those without. Among sickle cell anemia patients with two alpha genes, the estimated incidence of leg ulcers is 2.38 per 100 person years and 6.12 per 100 person years among sickle cell anemia patients with three alpha genes (P less than .05). In both groups, the incidence was highest among those patients over 20 years of age and considerably higher among males than females (P less than .001). Leg ulcers were nonexistent in patients with sickle beta plus thalassemia and sickle hemoglobin C disease. Low steady-state hemoglobin is associated with a higher incidence of ulcer formation (P less than .0001) in sickle cell anemia patients. The protective effect of hemoglobin F is apparent at all levels of total hemoglobin among sickle cell anemia patients and those with associated alpha-thalassemia. SN - 0006-4971 UR - https://www.unboundmedicine.com/medline/citation/2475188/Leg_ulcers_in_patients_with_sickle_cell_disease_ L2 - http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=2475188 DB - PRIME DP - Unbound Medicine ER -