Citation
Prado, Renata Silva do, et al. "Inhibition of Paracoccidioides Lutzii Pb01 Isocitrate Lyase By the Natural Compound Argentilactone and Its Semi-synthetic Derivatives." PloS One, vol. 9, no. 4, 2014, pp. e94832.
Prado RS, Alves RJ, Oliveira CM, et al. Inhibition of Paracoccidioides lutzii Pb01 isocitrate lyase by the natural compound argentilactone and its semi-synthetic derivatives. PLoS One. 2014;9(4):e94832.
Prado, R. S., Alves, R. J., Oliveira, C. M., Kato, L., Silva, R. A., Quintino, G. O., do Desterro Cunha, S., de Almeida Soares, C. M., & Pereira, M. (2014). Inhibition of Paracoccidioides lutzii Pb01 isocitrate lyase by the natural compound argentilactone and its semi-synthetic derivatives. PloS One, 9(4), e94832. https://doi.org/10.1371/journal.pone.0094832
Prado RS, et al. Inhibition of Paracoccidioides Lutzii Pb01 Isocitrate Lyase By the Natural Compound Argentilactone and Its Semi-synthetic Derivatives. PLoS One. 2014;9(4):e94832. PubMed PMID: 24752170.
TY - JOUR
T1 - Inhibition of Paracoccidioides lutzii Pb01 isocitrate lyase by the natural compound argentilactone and its semi-synthetic derivatives.
AU - Prado,Renata Silva do,
AU - Alves,Ricardo Justino,
AU - Oliveira,Cecília Maria Alves de,
AU - Kato,Lucília,
AU - Silva,Roosevelt Alves da,
AU - Quintino,Guilherme Oliveira,
AU - do Desterro Cunha,Silvio,
AU - de Almeida Soares,Célia Maria,
AU - Pereira,Maristela,
Y1 - 2014/04/21/
PY - 2013/12/02/received
PY - 2014/03/20/accepted
PY - 2014/4/23/entrez
PY - 2014/4/23/pubmed
PY - 2015/1/21/medline
SP - e94832
EP - e94832
JF - PloS one
JO - PLoS One
VL - 9
IS - 4
N2 - The dimorphic fungus Paracoccidioides spp. is responsible for paracoccidioidomycosis, the most prevalent systemic mycosis in Latin America, causing serious public health problems. Adequate treatment of mycotic infections is difficult, since fungi are eukaryotic organisms with a structure and metabolism similar to those of eukaryotic hosts. In this way, specific fungus targets have become important to search of new antifungal compound. The role of the glyoxylate cycle and its enzymes in microbial virulence has been reported in many fungal pathogens, including Paracoccidioides spp. Here, we show the action of argentilactone and its semi-synthetic derivative reduced argentilactone on recombinant and native isocitrate lyase from Paracoccidioides lutzii Pb01 (PbICL) in the presence of different carbon sources, acetate and glucose. Additionally, argentilactone and its semi-synthetic derivative reduced argentilactone exhibited relevant inhibitory activity against P. lutzii Pb01 yeast cells and dose-dependently influenced the transition from the mycelium to yeast phase. The other oxygenated derivatives tested, epoxy argentilactone and diol argentilactone-, did not show inhibitory action on the fungus. The results were supported by in silico experiments.
SN - 1932-6203
UR - https://www.unboundmedicine.com/medline/citation/24752170/Inhibition_of_Paracoccidioides_lutzii_Pb01_isocitrate_lyase_by_the_natural_compound_argentilactone_and_its_semi_synthetic_derivatives_
L2 - https://dx.plos.org/10.1371/journal.pone.0094832
DB - PRIME
DP - Unbound Medicine
ER -