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Strain types and antimicrobial resistance patterns of Clostridium difficile isolates from the United States, 2011 to 2013.
Antimicrob Agents Chemother. 2014 Jul; 58(7):4214-8.AA

Abstract

We determined the PCR ribotypes and antimicrobial susceptibility patterns of 508 toxigenic Clostridium difficile isolates collected between 2011 and 2013 from 32 U.S. hospitals. Of the 29 PCR ribotypes identified, the 027 strain type was the most common (28.1%), although the rates varied by geographic region. Ribotype 014/020 isolates appear to be emerging. Clindamycin and moxifloxacin resistances (36.8% and 35.8%, respectively) were the most frequent resistance phenotypes observed. Reduced susceptibility to vancomycin was observed in 39.1% of 027 isolates.

Links

Publisher Full Text
ncbi.nlm.nih.gov
aac.asm.org
PMC Free PDF

Authors+Show Affiliations

Tickler IA
Cepheid, Sunnyvale, California, USA isabella.tickler@cepheid.com.
Goering RV
Creighton University, Omaha, Nebraska, USA.
Whitmore JD
Cepheid, Sunnyvale, California, USA.
Lynn AN
Creighton University, Omaha, Nebraska, USA.
Persing DH
Cepheid, Sunnyvale, California, USA.
Tenover FC
Cepheid, Sunnyvale, California, USA.
Healthcare Associated Infection Consortium
No affiliation info available

MeSH

Anti-Bacterial AgentsClindamycinClostridioides difficileClostridium InfectionsDrug Resistance, Multiple, BacterialFecesFluoroquinolonesHumansMicrobial Sensitivity TestsMoxifloxacinRibotypingUnited StatesVancomycinVancomycin Resistance

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24752264

Citation

Tickler, Isabella A., et al. "Strain Types and Antimicrobial Resistance Patterns of Clostridium Difficile Isolates From the United States, 2011 to 2013." Antimicrobial Agents and Chemotherapy, vol. 58, no. 7, 2014, pp. 4214-8.
Tickler IA, Goering RV, Whitmore JD, et al. Strain types and antimicrobial resistance patterns of Clostridium difficile isolates from the United States, 2011 to 2013. Antimicrob Agents Chemother. 2014;58(7):4214-8.
Tickler, I. A., Goering, R. V., Whitmore, J. D., Lynn, A. N., Persing, D. H., & Tenover, F. C. (2014). Strain types and antimicrobial resistance patterns of Clostridium difficile isolates from the United States, 2011 to 2013. Antimicrobial Agents and Chemotherapy, 58(7), 4214-8. https://doi.org/10.1128/AAC.02775-13
Tickler IA, et al. Strain Types and Antimicrobial Resistance Patterns of Clostridium Difficile Isolates From the United States, 2011 to 2013. Antimicrob Agents Chemother. 2014;58(7):4214-8. PubMed PMID: 24752264.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Strain types and antimicrobial resistance patterns of Clostridium difficile isolates from the United States, 2011 to 2013. AU - Tickler,Isabella A, AU - Goering,Richard V, AU - Whitmore,Joseph D, AU - Lynn,Ashley N W, AU - Persing,David H, AU - Tenover,Fred C, AU - ,, Y1 - 2014/04/21/ PY - 2014/4/23/entrez PY - 2014/4/23/pubmed PY - 2015/9/12/medline SP - 4214 EP - 8 JF - Antimicrobial agents and chemotherapy JO - Antimicrob Agents Chemother VL - 58 IS - 7 N2 - We determined the PCR ribotypes and antimicrobial susceptibility patterns of 508 toxigenic Clostridium difficile isolates collected between 2011 and 2013 from 32 U.S. hospitals. Of the 29 PCR ribotypes identified, the 027 strain type was the most common (28.1%), although the rates varied by geographic region. Ribotype 014/020 isolates appear to be emerging. Clindamycin and moxifloxacin resistances (36.8% and 35.8%, respectively) were the most frequent resistance phenotypes observed. Reduced susceptibility to vancomycin was observed in 39.1% of 027 isolates. SN - 1098-6596 UR - https://www.unboundmedicine.com/medline/citation/24752264/Strain_types_and_antimicrobial_resistance_patterns_of_Clostridium_difficile_isolates_from_the_United_States_2011_to_2013_ L2 - http://aac.asm.org/cgi/pmidlookup?view=long&pmid=24752264 DB - PRIME DP - Unbound Medicine ER -