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Association between source-specific particulate matter air pollution and hs-CRP: local traffic and industrial emissions.
Environ Health Perspect. 2014 Jul; 122(7):703-10.EH

Abstract

BACKGROUND

Long-term exposures to particulate matter air pollution (PM2.5 and PM10) and high traffic load have been associated with markers of systemic inflammation. Epidemiological investigations have focused primarily on total PM, which represents a mixture of pollutants originating from different sources.

OBJECTIVE

We investigated associations between source-specific PM and high-sensitive C-reactive protein (hs-CRP), an independent predictor of cardiovascular disease.

METHODS

We used data from the first (2000-2003) and second examination (2006-2008) of the Heinz Nixdorf Recall study, a prospective population-based German cohort of initially 4,814 participants (45-75 years of age). We estimated residential long-term exposure to local traffic- and industry-specific fine particulate matter (PM2.5) at participants' residences using a chemistry transport model. We used a linear mixed model with a random participant intercept to estimate associations of source-specific PM and natural log-transformed hs-CRP, controlling for age, sex, education, body mass index, low- and high-density lipoprotein cholesterol, smoking variables, physical activity, season, humidity, and city (8,204 total observations).

RESULTS

A 1-μg/m3 increase in total PM2.5 was associated with a 4.53% increase in hs-CRP concentration (95% CI: 2.76, 6.33%). hs-CRP was 17.89% (95% CI: 7.66, 29.09%) and 7.96% (95% CI: 3.45, 12.67%) higher in association with 1-μg/m3 increases in traffic- and industry-specific PM2.5, respectively. RESULTS for PM10 were similar.

CONCLUSIONS

Long-term exposure to local traffic-specific PM (PM2.5, PM10) was more strongly associated with systemic inflammation than total PM. Associations of local industry-specific PM were slightly stronger but not significantly different from associations with total PM.

Authors+Show Affiliations

IUF-Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24755038

Citation

Hennig, Frauke, et al. "Association Between Source-specific Particulate Matter Air Pollution and hs-CRP: Local Traffic and Industrial Emissions." Environmental Health Perspectives, vol. 122, no. 7, 2014, pp. 703-10.
Hennig F, Fuks K, Moebus S, et al. Association between source-specific particulate matter air pollution and hs-CRP: local traffic and industrial emissions. Environ Health Perspect. 2014;122(7):703-10.
Hennig, F., Fuks, K., Moebus, S., Weinmayr, G., Memmesheimer, M., Jakobs, H., Bröcker-Preuss, M., Führer-Sakel, D., Möhlenkamp, S., Erbel, R., Jöckel, K. H., & Hoffmann, B. (2014). Association between source-specific particulate matter air pollution and hs-CRP: local traffic and industrial emissions. Environmental Health Perspectives, 122(7), 703-10. https://doi.org/10.1289/ehp.1307081
Hennig F, et al. Association Between Source-specific Particulate Matter Air Pollution and hs-CRP: Local Traffic and Industrial Emissions. Environ Health Perspect. 2014;122(7):703-10. PubMed PMID: 24755038.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between source-specific particulate matter air pollution and hs-CRP: local traffic and industrial emissions. AU - Hennig,Frauke, AU - Fuks,Kateryna, AU - Moebus,Susanne, AU - Weinmayr,Gudrun, AU - Memmesheimer,Michael, AU - Jakobs,Hermann, AU - Bröcker-Preuss,Martina, AU - Führer-Sakel,Dagmar, AU - Möhlenkamp,Stefan, AU - Erbel,Raimund, AU - Jöckel,Karl-Heinz, AU - Hoffmann,Barbara, AU - ,, Y1 - 2014/04/22/ PY - 2013/05/14/received PY - 2014/04/18/accepted PY - 2014/4/24/entrez PY - 2014/4/24/pubmed PY - 2015/2/24/medline SP - 703 EP - 10 JF - Environmental health perspectives JO - Environ. Health Perspect. VL - 122 IS - 7 N2 - BACKGROUND: Long-term exposures to particulate matter air pollution (PM2.5 and PM10) and high traffic load have been associated with markers of systemic inflammation. Epidemiological investigations have focused primarily on total PM, which represents a mixture of pollutants originating from different sources. OBJECTIVE: We investigated associations between source-specific PM and high-sensitive C-reactive protein (hs-CRP), an independent predictor of cardiovascular disease. METHODS: We used data from the first (2000-2003) and second examination (2006-2008) of the Heinz Nixdorf Recall study, a prospective population-based German cohort of initially 4,814 participants (45-75 years of age). We estimated residential long-term exposure to local traffic- and industry-specific fine particulate matter (PM2.5) at participants' residences using a chemistry transport model. We used a linear mixed model with a random participant intercept to estimate associations of source-specific PM and natural log-transformed hs-CRP, controlling for age, sex, education, body mass index, low- and high-density lipoprotein cholesterol, smoking variables, physical activity, season, humidity, and city (8,204 total observations). RESULTS: A 1-μg/m3 increase in total PM2.5 was associated with a 4.53% increase in hs-CRP concentration (95% CI: 2.76, 6.33%). hs-CRP was 17.89% (95% CI: 7.66, 29.09%) and 7.96% (95% CI: 3.45, 12.67%) higher in association with 1-μg/m3 increases in traffic- and industry-specific PM2.5, respectively. RESULTS for PM10 were similar. CONCLUSIONS: Long-term exposure to local traffic-specific PM (PM2.5, PM10) was more strongly associated with systemic inflammation than total PM. Associations of local industry-specific PM were slightly stronger but not significantly different from associations with total PM. SN - 1552-9924 UR - https://www.unboundmedicine.com/medline/citation/24755038/Association_between_source_specific_particulate_matter_air_pollution_and_hs_CRP:_local_traffic_and_industrial_emissions_ L2 - https://ehp.niehs.nih.gov/doi/full/10.1289/ehp.1307081?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -