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Protective effects of exogenous β-hydroxybutyrate on paraquat toxicity in rat kidney.
Biochem Biophys Res Commun. 2014 May 16; 447(4):666-71.BB

Abstract

In this study, we demonstrated the protective effects of β-hydroxybutyrate (β-HB) against paraquat (PQ)-induced kidney injury and elucidated the underlying molecular mechanisms. By histological examination and renal dysfunction specific markers (serum BUN and creatinine) assay, β-HB could protect the PQ-induced kidney injury in rat. PQ-induced kidney injury is associated with oxidative stress, which was measured by increased lipid peroxidation (MDA) and decreased intracellular anti-oxidative abilities (SOD, CAT and GSH). β-HB pretreatment significantly attenuated that. Caspase-mediated apoptosis pathway contributed importantly to PQ toxicity, as revealed by the activation of caspase-9/-3, cleavage of PARP, and regulation of Bcl-2 and Bax, which were also effectively blocked by β-HB. Moreover, treatment of PQ strongly decreased the nuclear Nrf2 levels. However, pre-treatment with β-HB effectively suppressed this action of PQ. This may imply the important role of β-HB on Nrf2 pathway. Taken together, this study provides a novel finding that β-HB has a renoprotective ability against paraquat-induced kidney injury.

Authors+Show Affiliations

College of Veterinary Medicine, Jilin University, China.College of Veterinary Medicine, Jilin University, China.College of Veterinary Medicine, Jilin University, China.College of Veterinary Medicine, Jilin University, China. Electronic address: xiegh@jlu.edu.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24755084

Citation

Wei, Teng, et al. "Protective Effects of Exogenous Β-hydroxybutyrate On Paraquat Toxicity in Rat Kidney." Biochemical and Biophysical Research Communications, vol. 447, no. 4, 2014, pp. 666-71.
Wei T, Tian W, Liu F, et al. Protective effects of exogenous β-hydroxybutyrate on paraquat toxicity in rat kidney. Biochem Biophys Res Commun. 2014;447(4):666-71.
Wei, T., Tian, W., Liu, F., & Xie, G. (2014). Protective effects of exogenous β-hydroxybutyrate on paraquat toxicity in rat kidney. Biochemical and Biophysical Research Communications, 447(4), 666-71. https://doi.org/10.1016/j.bbrc.2014.04.074
Wei T, et al. Protective Effects of Exogenous Β-hydroxybutyrate On Paraquat Toxicity in Rat Kidney. Biochem Biophys Res Commun. 2014 May 16;447(4):666-71. PubMed PMID: 24755084.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effects of exogenous β-hydroxybutyrate on paraquat toxicity in rat kidney. AU - Wei,Teng, AU - Tian,Wulin, AU - Liu,Fangning, AU - Xie,Guanghong, Y1 - 2014/04/19/ PY - 2014/04/10/received PY - 2014/04/14/accepted PY - 2014/4/24/entrez PY - 2014/4/24/pubmed PY - 2014/8/15/medline KW - Apoptosis KW - Kidney injury KW - Oxidative stress KW - Paraquat KW - β-Hydroxybutyrate SP - 666 EP - 71 JF - Biochemical and biophysical research communications JO - Biochem Biophys Res Commun VL - 447 IS - 4 N2 - In this study, we demonstrated the protective effects of β-hydroxybutyrate (β-HB) against paraquat (PQ)-induced kidney injury and elucidated the underlying molecular mechanisms. By histological examination and renal dysfunction specific markers (serum BUN and creatinine) assay, β-HB could protect the PQ-induced kidney injury in rat. PQ-induced kidney injury is associated with oxidative stress, which was measured by increased lipid peroxidation (MDA) and decreased intracellular anti-oxidative abilities (SOD, CAT and GSH). β-HB pretreatment significantly attenuated that. Caspase-mediated apoptosis pathway contributed importantly to PQ toxicity, as revealed by the activation of caspase-9/-3, cleavage of PARP, and regulation of Bcl-2 and Bax, which were also effectively blocked by β-HB. Moreover, treatment of PQ strongly decreased the nuclear Nrf2 levels. However, pre-treatment with β-HB effectively suppressed this action of PQ. This may imply the important role of β-HB on Nrf2 pathway. Taken together, this study provides a novel finding that β-HB has a renoprotective ability against paraquat-induced kidney injury. SN - 1090-2104 UR - https://www.unboundmedicine.com/medline/citation/24755084/Protective_effects_of_exogenous_��_hydroxybutyrate_on_paraquat_toxicity_in_rat_kidney_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(14)00716-5 DB - PRIME DP - Unbound Medicine ER -