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Apolipoprotein E gene polymorphism and risk for coronary heart disease in the Chinese population: a meta-analysis of 61 studies including 6634 cases and 6393 controls.
PLoS One. 2014; 9(4):e95463.Plos

Abstract

BACKGROUND

Numerous studies have evaluated the association between the apolipoprotein E (apoE) gene polymorphisms in coronary heart disease (CHD). However, the results remain uncertain. We carried out a meta-analysis to derive a more comprehensive estimation of the association in Chinese population.

METHODS

Case-control studies in Chinese and English publications were identified by searching databases of PubMed, EMBASE, Web of Science, CNKI, CBM, Wanfang, VIP and hand searching of relevant journals and the reference lists of retrieved articles. Odds ratio (OR) and 95% confidence interval (CI) were applied to assess the strength of the associations. Subgroup analysis and sensitivity analysis were performed to explore the between-study heterogeneity.

RESULTS

We finally identified 61 relevant studies which comprised 6634 case-patients and 6393 controls. The pooled OR for ε4 carriers was 96% higher than the ε3/3 genotype for CHD (OR, 1.96; 95% CI, 1.70 to 2.24; P<0.001). However, there was no evidence of statistically significant association between ε2 carriers and risk of CHD (OR, 1.02; 95% CI, 0.91 to 1.13; P = 0.729). In the subgroup analysis, different endpoints may partially account for the heterogeneity. No publication bias was found.

CONCLUSIONS

Our meta-analysis suggests that the apoE ε4 allele may be a risk factor for CHD in the Chinese population, however, ε2 allele has no significant association.

Authors+Show Affiliations

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China; Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China.Department of Cardiology, The Fourth Affiliated Hospital of Anhui Medical University, Anhui, China.Department of Cardiology, Rizhao People's Hospital, Shandong, China.Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China; Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China; Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China.Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China; Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24755673

Citation

Zhang, Ming-duo, et al. "Apolipoprotein E Gene Polymorphism and Risk for Coronary Heart Disease in the Chinese Population: a Meta-analysis of 61 Studies Including 6634 Cases and 6393 Controls." PloS One, vol. 9, no. 4, 2014, pp. e95463.
Zhang MD, Gu W, Qiao SB, et al. Apolipoprotein E gene polymorphism and risk for coronary heart disease in the Chinese population: a meta-analysis of 61 studies including 6634 cases and 6393 controls. PLoS One. 2014;9(4):e95463.
Zhang, M. D., Gu, W., Qiao, S. B., Zhu, E. J., Zhao, Q. M., & Lv, S. Z. (2014). Apolipoprotein E gene polymorphism and risk for coronary heart disease in the Chinese population: a meta-analysis of 61 studies including 6634 cases and 6393 controls. PloS One, 9(4), e95463. https://doi.org/10.1371/journal.pone.0095463
Zhang MD, et al. Apolipoprotein E Gene Polymorphism and Risk for Coronary Heart Disease in the Chinese Population: a Meta-analysis of 61 Studies Including 6634 Cases and 6393 Controls. PLoS One. 2014;9(4):e95463. PubMed PMID: 24755673.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein E gene polymorphism and risk for coronary heart disease in the Chinese population: a meta-analysis of 61 studies including 6634 cases and 6393 controls. AU - Zhang,Ming-duo, AU - Gu,Wei, AU - Qiao,Shi-bin, AU - Zhu,En-jun, AU - Zhao,Quan-ming, AU - Lv,Shu-zheng, Y1 - 2014/04/22/ PY - 2013/11/15/received PY - 2014/03/27/accepted PY - 2014/4/24/entrez PY - 2014/4/24/pubmed PY - 2015/1/16/medline SP - e95463 EP - e95463 JF - PloS one JO - PLoS One VL - 9 IS - 4 N2 - BACKGROUND: Numerous studies have evaluated the association between the apolipoprotein E (apoE) gene polymorphisms in coronary heart disease (CHD). However, the results remain uncertain. We carried out a meta-analysis to derive a more comprehensive estimation of the association in Chinese population. METHODS: Case-control studies in Chinese and English publications were identified by searching databases of PubMed, EMBASE, Web of Science, CNKI, CBM, Wanfang, VIP and hand searching of relevant journals and the reference lists of retrieved articles. Odds ratio (OR) and 95% confidence interval (CI) were applied to assess the strength of the associations. Subgroup analysis and sensitivity analysis were performed to explore the between-study heterogeneity. RESULTS: We finally identified 61 relevant studies which comprised 6634 case-patients and 6393 controls. The pooled OR for ε4 carriers was 96% higher than the ε3/3 genotype for CHD (OR, 1.96; 95% CI, 1.70 to 2.24; P<0.001). However, there was no evidence of statistically significant association between ε2 carriers and risk of CHD (OR, 1.02; 95% CI, 0.91 to 1.13; P = 0.729). In the subgroup analysis, different endpoints may partially account for the heterogeneity. No publication bias was found. CONCLUSIONS: Our meta-analysis suggests that the apoE ε4 allele may be a risk factor for CHD in the Chinese population, however, ε2 allele has no significant association. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/24755673/Apolipoprotein_E_gene_polymorphism_and_risk_for_coronary_heart_disease_in_the_Chinese_population:_a_meta_analysis_of_61_studies_including_6634_cases_and_6393_controls_ L2 - https://dx.plos.org/10.1371/journal.pone.0095463 DB - PRIME DP - Unbound Medicine ER -