Tags

Type your tag names separated by a space and hit enter

[Treatment of rheumatoid arthritis by Yangxue Tongluo Recipe combined with immunosuppressive agents: a clinical observation].

Abstract

OBJECTIVE

To observe the therapeutic effect of Yangxue Tongluo Recipe (YTR) combined with immunosuppressive agents in the treatment of rheumatoid arthritis (RA).

METHODS

Totally 88 RA patients were randomly assigned to the treatment group [47 cases, YTR combined Methotrexate (MTX) + Leflunomide (LEF) treatment] and the control group (41 cases, MTX + LEF therapy). All patients received 12-week treatment. Clinical symptoms and signs, laboratory tests [erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), and C reactive protein (CRP)], and adverse reactions were observed before and after treatment.

RESULTS

The total effective rate was 91.5% (43/47 cases) in the treatment group, and the total effective rate was 75.6% (31/41 cases) in the control group. There was statistical difference between the two groups (P < 0.05). The morning stiffness, the rest pain, the number of tender joints, the number of swollen joints, tender joint index, swollen joint index, ESR, RF, and CRP were significantly improved in the two groups after treatment (P < 0.01). Besides, clinical symptoms and signs, ESR, RF, and CRP were more improved in the treatment group after treatment, when compared with those in the control group (P < 0.05). Gastrointestinal discomfort was the main adverse reaction in the two groups, but the occurrence was lower in the treatment group than in the control group (P > 0.05).

CONCLUSIONS

The clinical efficacy of YTR combined MTX + LEF in the treatment of RA was better than using Western medicine alone. It was more safe with less adverse reactions.

Authors

,

Source

MeSH

Adult
Antirheumatic Agents
Arthritis, Rheumatoid
Drug Therapy, Combination
Drugs, Chinese Herbal
Female
Humans
Immunosuppressive Agents
Male
Methotrexate
Middle Aged
Phytotherapy
Treatment Outcome

Pub Type(s)

English Abstract
Journal Article
Randomized Controlled Trial

Language

chi

PubMed ID

24758075

Citation

Wang, Zhen, and Xiao-Juan Tao. "[Treatment of Rheumatoid Arthritis By Yangxue Tongluo Recipe Combined With Immunosuppressive Agents: a Clinical Observation]." Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine, vol. 34, no. 3, 2014, pp. 276-8.
Wang Z, Tao XJ. [Treatment of rheumatoid arthritis by Yangxue Tongluo Recipe combined with immunosuppressive agents: a clinical observation]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2014;34(3):276-8.
Wang, Z., & Tao, X. J. (2014). [Treatment of rheumatoid arthritis by Yangxue Tongluo Recipe combined with immunosuppressive agents: a clinical observation]. Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine, 34(3), pp. 276-8.
Wang Z, Tao XJ. [Treatment of Rheumatoid Arthritis By Yangxue Tongluo Recipe Combined With Immunosuppressive Agents: a Clinical Observation]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2014;34(3):276-8. PubMed PMID: 24758075.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Treatment of rheumatoid arthritis by Yangxue Tongluo Recipe combined with immunosuppressive agents: a clinical observation]. AU - Wang,Zhen, AU - Tao,Xiao-Juan, PY - 2014/4/25/entrez PY - 2014/4/25/pubmed PY - 2015/1/6/medline SP - 276 EP - 8 JF - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine JO - Zhongguo Zhong Xi Yi Jie He Za Zhi VL - 34 IS - 3 N2 - OBJECTIVE: To observe the therapeutic effect of Yangxue Tongluo Recipe (YTR) combined with immunosuppressive agents in the treatment of rheumatoid arthritis (RA). METHODS: Totally 88 RA patients were randomly assigned to the treatment group [47 cases, YTR combined Methotrexate (MTX) + Leflunomide (LEF) treatment] and the control group (41 cases, MTX + LEF therapy). All patients received 12-week treatment. Clinical symptoms and signs, laboratory tests [erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), and C reactive protein (CRP)], and adverse reactions were observed before and after treatment. RESULTS: The total effective rate was 91.5% (43/47 cases) in the treatment group, and the total effective rate was 75.6% (31/41 cases) in the control group. There was statistical difference between the two groups (P < 0.05). The morning stiffness, the rest pain, the number of tender joints, the number of swollen joints, tender joint index, swollen joint index, ESR, RF, and CRP were significantly improved in the two groups after treatment (P < 0.01). Besides, clinical symptoms and signs, ESR, RF, and CRP were more improved in the treatment group after treatment, when compared with those in the control group (P < 0.05). Gastrointestinal discomfort was the main adverse reaction in the two groups, but the occurrence was lower in the treatment group than in the control group (P > 0.05). CONCLUSIONS: The clinical efficacy of YTR combined MTX + LEF in the treatment of RA was better than using Western medicine alone. It was more safe with less adverse reactions. SN - 1003-5370 UR - https://www.unboundmedicine.com/medline/citation/24758075/[Treatment_of_rheumatoid_arthritis_by_Yangxue_Tongluo_Recipe_combined_with_immunosuppressive_agents:_a_clinical_observation]_ L2 - http://www.diseaseinfosearch.org/result/592 DB - PRIME DP - Unbound Medicine ER -