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Oxidative stress in patients with thyroidectomy and thyroparathyroidectomy under replacement therapy.

Abstract

Several studies have demonstrated an imbalance between free radicals and the antioxidative system in individuals with thyroid dysfunction. However, oxidative stress has not been evaluated in patients with thyroidectomy and thyroparathyroidectomy, who are under replacement therapy. The objective of this study was to evaluate the oxidative stress using malondialdehyde, nitric oxide, and catalase levels in patients with thyroidectomy and thyroparathyroidectomy. Nineteen patients with thyroidectomy, 20 patients with thyroparathyroidectomy, and 20 controls with no history of thyroid or parathyroid disease or surgery were included in the study. Serum malondialdehyde, nitric oxide, and catalase levels were examined. Levels of nitric oxide and malondialdehyde were elevated, and catalase levels decreased in patients with thyroidectomy and thyroparathyroidectomy compared with controls (p value for all the parameters: p<0.001). Free tetraiodothyronine was a potential predictor of malondialdehyde in the patient groups (p: 0.002). Catalase was negatively correlated with nitric oxide (p<0.01) and malondialdehyde (p<0.01). The results of the current study demonstrated that oxidative stress increased in patients with thyroidectomy and thyroparathyroidectomy despite the application of replacement therapies.

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  • Authors+Show Affiliations

    ,

    Department of Internal Medicine, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey.

    , , ,

    Source

    Endocrine 48:1 2015 Feb pg 227-32

    MeSH

    Adult
    Calcium
    Catalase
    Female
    Goiter, Nodular
    Hormone Replacement Therapy
    Humans
    Male
    Malondialdehyde
    Middle Aged
    Nitric Oxide
    Oxidative Stress
    Parathyroidectomy
    Reactive Oxygen Species
    Thyroidectomy
    Thyrotropin
    Thyroxine

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    24760660

    Citation

    Kaçmaz, Murat, et al. "Oxidative Stress in Patients With Thyroidectomy and Thyroparathyroidectomy Under Replacement Therapy." Endocrine, vol. 48, no. 1, 2015, pp. 227-32.
    Kaçmaz M, Atmaca M, Arslan A, et al. Oxidative stress in patients with thyroidectomy and thyroparathyroidectomy under replacement therapy. Endocrine. 2015;48(1):227-32.
    Kaçmaz, M., Atmaca, M., Arslan, A., Demir, H., & Özbay, M. F. (2015). Oxidative stress in patients with thyroidectomy and thyroparathyroidectomy under replacement therapy. Endocrine, 48(1), pp. 227-32. doi:10.1007/s12020-014-0270-6.
    Kaçmaz M, et al. Oxidative Stress in Patients With Thyroidectomy and Thyroparathyroidectomy Under Replacement Therapy. Endocrine. 2015;48(1):227-32. PubMed PMID: 24760660.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Oxidative stress in patients with thyroidectomy and thyroparathyroidectomy under replacement therapy. AU - Kaçmaz,Murat, AU - Atmaca,Murat, AU - Arslan,Ayşe, AU - Demir,Halit, AU - Özbay,Mehmet Fatih, Y1 - 2014/04/24/ PY - 2013/12/20/received PY - 2014/04/08/accepted PY - 2014/4/25/entrez PY - 2014/4/25/pubmed PY - 2015/11/11/medline SP - 227 EP - 32 JF - Endocrine JO - Endocrine VL - 48 IS - 1 N2 - Several studies have demonstrated an imbalance between free radicals and the antioxidative system in individuals with thyroid dysfunction. However, oxidative stress has not been evaluated in patients with thyroidectomy and thyroparathyroidectomy, who are under replacement therapy. The objective of this study was to evaluate the oxidative stress using malondialdehyde, nitric oxide, and catalase levels in patients with thyroidectomy and thyroparathyroidectomy. Nineteen patients with thyroidectomy, 20 patients with thyroparathyroidectomy, and 20 controls with no history of thyroid or parathyroid disease or surgery were included in the study. Serum malondialdehyde, nitric oxide, and catalase levels were examined. Levels of nitric oxide and malondialdehyde were elevated, and catalase levels decreased in patients with thyroidectomy and thyroparathyroidectomy compared with controls (p value for all the parameters: p<0.001). Free tetraiodothyronine was a potential predictor of malondialdehyde in the patient groups (p: 0.002). Catalase was negatively correlated with nitric oxide (p<0.01) and malondialdehyde (p<0.01). The results of the current study demonstrated that oxidative stress increased in patients with thyroidectomy and thyroparathyroidectomy despite the application of replacement therapies. SN - 1559-0100 UR - https://www.unboundmedicine.com/medline/citation/24760660/Oxidative_stress_in_patients_with_thyroidectomy_and_thyroparathyroidectomy_under_replacement_therapy L2 - https://dx.doi.org/10.1007/s12020-014-0270-6 DB - PRIME DP - Unbound Medicine ER -