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Pharmacognostical standardization and antidiabetic activity of Syzygium cumini (Linn.) barks (Myrtaceae) on streptozotocin-induced diabetic rats.
J Complement Integr Med. 2014 Jun; 11(2):71-81.JC

Abstract

BACKGROUND

The objectives of the present study were phytochemical and pharmacological screening of bark of Syzygium cumini on streptozotocin (STZ)-induced diabetic Wistar albino rats.

METHODS

Dose selection was made on the basis of acute oral toxicity study (300-5,000 mg/kg b.w.) as per OECD guidelines. Rats were made diabetic by a single dose of STZ at 50 mg/kg b.w. intraperitoneally. The effect of Syzygium cumini extracts (500 mg/kg) on postprandial blood glucose level was determined in fasted diabetic and normal rats. Blood glucose levels were measured at 0, 30, and 90 min after the glucose administration in the OGTT study. The bark extracts were administered orally at the dose of 500 mg/kg for 21 days in the chronic study. Glibenclamide (2.5 mg/kg) was used as a standard drug for activity comparison. Statistical analyses were performed using one-way ANOVA followed by Bonferroni's multiple comparison tests.

RESULTS

The phytochemical screening showed positive results for triterpenes/steroids, glycosides, carbohydrates, alkaloids, flavonoids, saponins, tannins and amino acids. Administration of Syzygium cumini extracts 30 min before oral glucose loading significantly suppressed (p<0.001) the rise in postprandial blood glucose levels in treated rats compared to control rats but less significant than glibenclamide. Daily, continuous oral treatment of STZ-induced diabetic with various extract of Syzygium cumini for 3 weeks resulted in significant reductions in fasting blood glucose levels compared with diabetic controls. The ethanol and aqueous extracts were most active.

CONCLUSIONS

This study brings out the evidence regarding phytochemistry and pharmacological activities of Syzygium cumini.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24760764

Citation

Tripathi, Akhilesh K., and Seema Kohli. "Pharmacognostical Standardization and Antidiabetic Activity of Syzygium Cumini (Linn.) Barks (Myrtaceae) On Streptozotocin-induced Diabetic Rats." Journal of Complementary & Integrative Medicine, vol. 11, no. 2, 2014, pp. 71-81.
Tripathi AK, Kohli S. Pharmacognostical standardization and antidiabetic activity of Syzygium cumini (Linn.) barks (Myrtaceae) on streptozotocin-induced diabetic rats. J Complement Integr Med. 2014;11(2):71-81.
Tripathi, A. K., & Kohli, S. (2014). Pharmacognostical standardization and antidiabetic activity of Syzygium cumini (Linn.) barks (Myrtaceae) on streptozotocin-induced diabetic rats. Journal of Complementary & Integrative Medicine, 11(2), 71-81. https://doi.org/10.1515/jcim-2014-0011
Tripathi AK, Kohli S. Pharmacognostical Standardization and Antidiabetic Activity of Syzygium Cumini (Linn.) Barks (Myrtaceae) On Streptozotocin-induced Diabetic Rats. J Complement Integr Med. 2014;11(2):71-81. PubMed PMID: 24760764.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacognostical standardization and antidiabetic activity of Syzygium cumini (Linn.) barks (Myrtaceae) on streptozotocin-induced diabetic rats. AU - Tripathi,Akhilesh K, AU - Kohli,Seema, PY - 2014/02/21/received PY - 2014/03/28/accepted PY - 2014/4/25/entrez PY - 2014/4/25/pubmed PY - 2015/1/7/medline SP - 71 EP - 81 JF - Journal of complementary & integrative medicine JO - J Complement Integr Med VL - 11 IS - 2 N2 - BACKGROUND: The objectives of the present study were phytochemical and pharmacological screening of bark of Syzygium cumini on streptozotocin (STZ)-induced diabetic Wistar albino rats. METHODS: Dose selection was made on the basis of acute oral toxicity study (300-5,000 mg/kg b.w.) as per OECD guidelines. Rats were made diabetic by a single dose of STZ at 50 mg/kg b.w. intraperitoneally. The effect of Syzygium cumini extracts (500 mg/kg) on postprandial blood glucose level was determined in fasted diabetic and normal rats. Blood glucose levels were measured at 0, 30, and 90 min after the glucose administration in the OGTT study. The bark extracts were administered orally at the dose of 500 mg/kg for 21 days in the chronic study. Glibenclamide (2.5 mg/kg) was used as a standard drug for activity comparison. Statistical analyses were performed using one-way ANOVA followed by Bonferroni's multiple comparison tests. RESULTS: The phytochemical screening showed positive results for triterpenes/steroids, glycosides, carbohydrates, alkaloids, flavonoids, saponins, tannins and amino acids. Administration of Syzygium cumini extracts 30 min before oral glucose loading significantly suppressed (p<0.001) the rise in postprandial blood glucose levels in treated rats compared to control rats but less significant than glibenclamide. Daily, continuous oral treatment of STZ-induced diabetic with various extract of Syzygium cumini for 3 weeks resulted in significant reductions in fasting blood glucose levels compared with diabetic controls. The ethanol and aqueous extracts were most active. CONCLUSIONS: This study brings out the evidence regarding phytochemistry and pharmacological activities of Syzygium cumini. SN - 1553-3840 UR - https://www.unboundmedicine.com/medline/citation/24760764/Pharmacognostical_standardization_and_antidiabetic_activity_of_Syzygium_cumini__Linn___barks__Myrtaceae__on_streptozotocin_induced_diabetic_rats_ L2 - https://www.degruyter.com/document/doi/10.1515/jcim-2014-0011 DB - PRIME DP - Unbound Medicine ER -