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Clinical symptoms in fibromyalgia are associated to catechol-O-methyltransferase (COMT) gene Val158Met polymorphism.

Abstract

1. Fibromyalgia syndrome (FMS) is a common chronic widespread pain syndrome mainly affecting women. The aim of this study was to explore the frequency and clinical significance of catechol-O-methyltransferase (COMT) gene Val158Met polymorphism in a large cohort of Turkish patients with FMS. 2. The study included 379 FMS patients and 290 controls. Genomic DNA was isolated and genotyped using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analyses. 3. The genotype frequencies of Val158Met polymorphism showed a small difference between FMS patients and healthy controls (p = 0.047), however, the Met/Met genotype was significantly higher in FMS patients than healthy controls (p = 0.016). No difference was observed for allele frequencies between two groups. Stratification analysis according to clinical features for this disease reveals that weight, FMS Impact Questionnaire score, algometry and Raynaud's syndrome, were detected to have statistically significant associations with Val158Met polymorphism (p = 0.037, p = 0.042, p = 0.039 and p = 0.033, respectively). Pain sensitivity, measured by algometry, was statistically higher in patients with Met/Met genotype than the patients with Val/Val and Val/Met genotypes (p = 0.017). 4. The results of this study suggested that COMT gene Val158Met polymorphism is positively associated with FMS and play a relevant role in the clinical symptoms of the disease.

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  • Authors+Show Affiliations

    ,

    Department of Physical Therapy and Rehabilitation, Faculty of Medicine .

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    MeSH

    Adult
    Amino Acid Substitution
    Case-Control Studies
    Catechol O-Methyltransferase
    Female
    Fibromyalgia
    Humans
    Male
    Middle Aged
    Polymorphism, Genetic
    Severity of Illness Index

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    24762091

    Citation

    Inanir, Ahmet, et al. "Clinical Symptoms in Fibromyalgia Are Associated to catechol-O-methyltransferase (COMT) Gene Val158Met Polymorphism." Xenobiotica; the Fate of Foreign Compounds in Biological Systems, vol. 44, no. 10, 2014, pp. 952-6.
    Inanir A, Karakus N, Ates O, et al. Clinical symptoms in fibromyalgia are associated to catechol-O-methyltransferase (COMT) gene Val158Met polymorphism. Xenobiotica. 2014;44(10):952-6.
    Inanir, A., Karakus, N., Ates, O., Sezer, S., Bozkurt, N., Inanir, S., & Yigit, S. (2014). Clinical symptoms in fibromyalgia are associated to catechol-O-methyltransferase (COMT) gene Val158Met polymorphism. Xenobiotica; the Fate of Foreign Compounds in Biological Systems, 44(10), pp. 952-6. doi:10.3109/00498254.2014.913083.
    Inanir A, et al. Clinical Symptoms in Fibromyalgia Are Associated to catechol-O-methyltransferase (COMT) Gene Val158Met Polymorphism. Xenobiotica. 2014;44(10):952-6. PubMed PMID: 24762091.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Clinical symptoms in fibromyalgia are associated to catechol-O-methyltransferase (COMT) gene Val158Met polymorphism. AU - Inanir,Ahmet, AU - Karakus,Nevin, AU - Ates,Omer, AU - Sezer,Saime, AU - Bozkurt,Nihan, AU - Inanir,Sema, AU - Yigit,Serbulent, Y1 - 2014/04/24/ PY - 2014/4/26/entrez PY - 2014/4/26/pubmed PY - 2015/5/30/medline KW - Catechol-O-methyltransferase KW - Val158Met polymorphism KW - fibromyalgia KW - pain SP - 952 EP - 6 JF - Xenobiotica; the fate of foreign compounds in biological systems JO - Xenobiotica VL - 44 IS - 10 N2 - 1. Fibromyalgia syndrome (FMS) is a common chronic widespread pain syndrome mainly affecting women. The aim of this study was to explore the frequency and clinical significance of catechol-O-methyltransferase (COMT) gene Val158Met polymorphism in a large cohort of Turkish patients with FMS. 2. The study included 379 FMS patients and 290 controls. Genomic DNA was isolated and genotyped using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analyses. 3. The genotype frequencies of Val158Met polymorphism showed a small difference between FMS patients and healthy controls (p = 0.047), however, the Met/Met genotype was significantly higher in FMS patients than healthy controls (p = 0.016). No difference was observed for allele frequencies between two groups. Stratification analysis according to clinical features for this disease reveals that weight, FMS Impact Questionnaire score, algometry and Raynaud's syndrome, were detected to have statistically significant associations with Val158Met polymorphism (p = 0.037, p = 0.042, p = 0.039 and p = 0.033, respectively). Pain sensitivity, measured by algometry, was statistically higher in patients with Met/Met genotype than the patients with Val/Val and Val/Met genotypes (p = 0.017). 4. The results of this study suggested that COMT gene Val158Met polymorphism is positively associated with FMS and play a relevant role in the clinical symptoms of the disease. SN - 1366-5928 UR - https://www.unboundmedicine.com/medline/citation/24762091/Clinical_symptoms_in_fibromyalgia_are_associated_to_catechol_O_methyltransferase__COMT__gene_Val158Met_polymorphism_ L2 - http://www.tandfonline.com/doi/full/10.3109/00498254.2014.913083 DB - PRIME DP - Unbound Medicine ER -