Tags

Type your tag names separated by a space and hit enter

First description of NDM-1-, KPC-2-, VIM-2- and IMP-4-producing Klebsiella pneumoniae strains in a single Chinese teaching hospital.
Epidemiol Infect. 2015 Jan; 143(2):376-84.EI

Abstract

A total of 180 non-duplicate carbapenem-resistant Klebsiella pneumoniae isolates were recovered from patients hospitalized between December 2010 and January 2012 at a Chinese hospital. Eight KPC-2, four NDM-1, one VIM-2, and five KPC-2 plus IMP-4 producers were identified and all were multidrug resistant due to the presence of other resistance determinants, including extended-spectrum β-lactamases (CTX-M-15, SHV-12), 16S rRNA methylases (armA, rmtB) and plasmid-mediated quinolone-resistance determinants (qnrA, B, S, aac(6')-Ib-cr). Nine K. pneumoniae clones (Kpn-A1/ST395, Kpn-A3/ST11, Kpn-A2/ST134, Kpn-B/ST263, Kpn-C/ST37, Kpn-D/ST39, Kpn-E/ST1151, Kpn-F/ST890, Kpn-G/ST1153) were identified. bla KPC-2 was located on transferable ~65 kb IncL/M (ST395, ST11, ST134, ST39) and ~100 kb IncA/C (ST37, ST1153, ST890) plasmids, respectively. On the other hand, bla NDM-1 was associated with a ~70 kb IncA/C plasmid (ST263). However, non-typable plasmids of ~40 kb containing bla VIM-2 were detected in the ST1151 clone. This work reports the first co-occurrence of four diverse types of carbapenemase of K. pneumoniae clones from a single hospital in China. IncA/C, IncL/M, and other successful plasmids may be important for the dissemination of carbapenemases, producing a complex epidemiological picture.

Authors+Show Affiliations

Department of Clinical Microbiology,First Affiliated Hospital of Nanchang University,Nanchang University, Nanchang, PRChina.Department of Clinical Microbiology,First Affiliated Hospital of Nanchang University,Nanchang University, Nanchang, PRChina.Department of Infection Control,First Affiliated Hospital of Nanchang University,Nanchang University, Nanchang, PRChina.Department of Infection Control,First Affiliated Hospital of Nanchang University,Nanchang University, Nanchang, PRChina.Department of Clinical Microbiology,First Affiliated Hospital of Nanchang University,Nanchang University, Nanchang, PRChina.Department of Clinical Microbiology,First Affiliated Hospital of Nanchang University,Nanchang University, Nanchang, PRChina.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24762211

Citation

Liu, Y, et al. "First Description of NDM-1-, KPC-2-, VIM-2- and IMP-4-producing Klebsiella Pneumoniae Strains in a Single Chinese Teaching Hospital." Epidemiology and Infection, vol. 143, no. 2, 2015, pp. 376-84.
Liu Y, Wan LG, Deng Q, et al. First description of NDM-1-, KPC-2-, VIM-2- and IMP-4-producing Klebsiella pneumoniae strains in a single Chinese teaching hospital. Epidemiol Infect. 2015;143(2):376-84.
Liu, Y., Wan, L. G., Deng, Q., Cao, X. W., Yu, Y., & Xu, Q. F. (2015). First description of NDM-1-, KPC-2-, VIM-2- and IMP-4-producing Klebsiella pneumoniae strains in a single Chinese teaching hospital. Epidemiology and Infection, 143(2), 376-84. https://doi.org/10.1017/S0950268814000995
Liu Y, et al. First Description of NDM-1-, KPC-2-, VIM-2- and IMP-4-producing Klebsiella Pneumoniae Strains in a Single Chinese Teaching Hospital. Epidemiol Infect. 2015;143(2):376-84. PubMed PMID: 24762211.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - First description of NDM-1-, KPC-2-, VIM-2- and IMP-4-producing Klebsiella pneumoniae strains in a single Chinese teaching hospital. AU - Liu,Y, AU - Wan,L-G, AU - Deng,Q, AU - Cao,X-W, AU - Yu,Y, AU - Xu,Q-F, Y1 - 2014/04/24/ PY - 2014/4/26/entrez PY - 2014/4/26/pubmed PY - 2015/3/3/medline SP - 376 EP - 84 JF - Epidemiology and infection JO - Epidemiol Infect VL - 143 IS - 2 N2 - A total of 180 non-duplicate carbapenem-resistant Klebsiella pneumoniae isolates were recovered from patients hospitalized between December 2010 and January 2012 at a Chinese hospital. Eight KPC-2, four NDM-1, one VIM-2, and five KPC-2 plus IMP-4 producers were identified and all were multidrug resistant due to the presence of other resistance determinants, including extended-spectrum β-lactamases (CTX-M-15, SHV-12), 16S rRNA methylases (armA, rmtB) and plasmid-mediated quinolone-resistance determinants (qnrA, B, S, aac(6')-Ib-cr). Nine K. pneumoniae clones (Kpn-A1/ST395, Kpn-A3/ST11, Kpn-A2/ST134, Kpn-B/ST263, Kpn-C/ST37, Kpn-D/ST39, Kpn-E/ST1151, Kpn-F/ST890, Kpn-G/ST1153) were identified. bla KPC-2 was located on transferable ~65 kb IncL/M (ST395, ST11, ST134, ST39) and ~100 kb IncA/C (ST37, ST1153, ST890) plasmids, respectively. On the other hand, bla NDM-1 was associated with a ~70 kb IncA/C plasmid (ST263). However, non-typable plasmids of ~40 kb containing bla VIM-2 were detected in the ST1151 clone. This work reports the first co-occurrence of four diverse types of carbapenemase of K. pneumoniae clones from a single hospital in China. IncA/C, IncL/M, and other successful plasmids may be important for the dissemination of carbapenemases, producing a complex epidemiological picture. SN - 1469-4409 UR - https://www.unboundmedicine.com/medline/citation/24762211/First_description_of_NDM_1__KPC_2__VIM_2__and_IMP_4_producing_Klebsiella_pneumoniae_strains_in_a_single_Chinese_teaching_hospital_ L2 - https://www.cambridge.org/core/product/identifier/S0950268814000995/type/journal_article DB - PRIME DP - Unbound Medicine ER -