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Evaluation of inner retinal layers in eyes with temporal hemianopic visual loss from chiasmal compression using optical coherence tomography.
Invest Ophthalmol Vis Sci. 2014 Apr 24; 55(5):3328-36.IO

Abstract

PURPOSE

We measured macular inner retinal layer thicknesses using frequency-domain optical coherence tomography (fd-OCT) and correlated these measures with visual field (VF) in eyes with temporal hemianopia from chiasmal compression and band atrophy (BA) of the optic nerve.

METHODS

Macular fd-OCT scans and VFs were obtained from 33 eyes of 33 patients with temporal hemianopia and 36 control eyes. The macular retinal nerve fiber layer (mRNFL), combined retinal ganglion cell and inner plexiform layers (RGCL+), and the inner nuclear layer (INL) were segmented. Measurements were averaged for each macula quadrant. Scans were assessed qualitatively for microcysts in the INL. The VF was estimated from the central 16 test points. The two groups were compared. Correlations between VF and OCT measurements were assessed.

RESULTS

The mRNFL, RGCL+, and total retinal (TR) macular thickness measurements were significantly smaller in BA eyes than controls. In the nasal quadrants, INL measurements were significantly greater in BA eyes than controls. The mRNFL and RGCL+ measurements had greater discrimination ability than TR measurements in the temporal quadrants. A significant correlation was found between most OCT parameters and their corresponding VF parameters. The strongest association was observed between RNFL and RGCL+ thickness, and VF loss in the corresponding area. The INL microcysts were found in seven eyes with BA, but not in controls.

CONCLUSIONS

Band atrophy leads to mRNFL and RGCL+ thinning, and INL thickening, and mRNFL and RGCL+ measurements are correlated strongly with VF loss. Segmented macular thickness measurements may be useful for quantifying neuronal loss in chiasmal compression.

Links

Authors+Show Affiliations

Division of Ophthalmology, University of São Paulo Medical School, São Paulo, Brazil.

Division of Ophthalmology, University of São Paulo Medical School, São Paulo, Brazil.

Division of Ophthalmology, University of São Paulo Medical School, São Paulo, Brazil.

Division of Ophthalmology, University of São Paulo Medical School, São Paulo, Brazil.

Division of Ophthalmology, University of São Paulo Medical School, São Paulo, Brazil.

Department of Psychology, Columbia University, New York, New York, United States Department of Neurobiology and Behavior, Columbia University, New York, New York, United States.

Department of Psychology, Columbia University, New York, New York, United States.

Department of Psychology, Columbia University, New York, New York, United States Department of Ophthalmology, Columbia University, New York, New York, United States.

MeSH

AdultConstriction, PathologicCross-Sectional StudiesFemaleFollow-Up StudiesHemianopsiaHumansMacula LuteaMaleMiddle AgedOptic ChiasmOptic Nerve DiseasesProspective StudiesRetinal Ganglion CellsTomography, Optical CoherenceVisual Field TestsVisual FieldsYoung Adult

Pub Type(s)

Journal Article

Observational Study

Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24764062

Citation

Monteiro, Mário L R., et al. "Evaluation of Inner Retinal Layers in Eyes With Temporal Hemianopic Visual Loss From Chiasmal Compression Using Optical Coherence Tomography." Investigative Ophthalmology & Visual Science, vol. 55, no. 5, 2014, pp. 3328-36.

Monteiro ML, Hokazono K, Fernandes DB, et al. Evaluation of inner retinal layers in eyes with temporal hemianopic visual loss from chiasmal compression using optical coherence tomography. Invest Ophthalmol Vis Sci. 2014;55(5):3328-36.

Monteiro, M. L., Hokazono, K., Fernandes, D. B., Costa-Cunha, L. V., Sousa, R. M., Raza, A. S., Wang, D. L., & Hood, D. C. (2014). Evaluation of inner retinal layers in eyes with temporal hemianopic visual loss from chiasmal compression using optical coherence tomography. Investigative Ophthalmology & Visual Science, 55(5), 3328-36. https://doi.org/10.1167/iovs.14-14118

Monteiro ML, et al. Evaluation of Inner Retinal Layers in Eyes With Temporal Hemianopic Visual Loss From Chiasmal Compression Using Optical Coherence Tomography. Invest Ophthalmol Vis Sci. 2014 Apr 24;55(5):3328-36. PubMed PMID: 24764062.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Evaluation of inner retinal layers in eyes with temporal hemianopic visual loss from chiasmal compression using optical coherence tomography. AU - Monteiro,Mário L R, AU - Hokazono,Kenzo, AU - Fernandes,Danilo B, AU - Costa-Cunha,Luciana V F, AU - Sousa,Rafael M, AU - Raza,Ali S, AU - Wang,Diane L, AU - Hood,Donald C, Y1 - 2014/04/24/ PY - 2014/4/26/entrez PY - 2014/4/26/pubmed PY - 2014/7/23/medline KW - band atrophy KW - inner nuclear layer KW - macular thickness KW - optical coherence tomography KW - retinal ganglion cell layer thickness KW - retinal nerve fiber layer SP - 3328 EP - 36 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 55 IS - 5 N2 - PURPOSE: We measured macular inner retinal layer thicknesses using frequency-domain optical coherence tomography (fd-OCT) and correlated these measures with visual field (VF) in eyes with temporal hemianopia from chiasmal compression and band atrophy (BA) of the optic nerve. METHODS: Macular fd-OCT scans and VFs were obtained from 33 eyes of 33 patients with temporal hemianopia and 36 control eyes. The macular retinal nerve fiber layer (mRNFL), combined retinal ganglion cell and inner plexiform layers (RGCL+), and the inner nuclear layer (INL) were segmented. Measurements were averaged for each macula quadrant. Scans were assessed qualitatively for microcysts in the INL. The VF was estimated from the central 16 test points. The two groups were compared. Correlations between VF and OCT measurements were assessed. RESULTS: The mRNFL, RGCL+, and total retinal (TR) macular thickness measurements were significantly smaller in BA eyes than controls. In the nasal quadrants, INL measurements were significantly greater in BA eyes than controls. The mRNFL and RGCL+ measurements had greater discrimination ability than TR measurements in the temporal quadrants. A significant correlation was found between most OCT parameters and their corresponding VF parameters. The strongest association was observed between RNFL and RGCL+ thickness, and VF loss in the corresponding area. The INL microcysts were found in seven eyes with BA, but not in controls. CONCLUSIONS: Band atrophy leads to mRNFL and RGCL+ thinning, and INL thickening, and mRNFL and RGCL+ measurements are correlated strongly with VF loss. Segmented macular thickness measurements may be useful for quantifying neuronal loss in chiasmal compression. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/24764062/Evaluation_of_inner_retinal_layers_in_eyes_with_temporal_hemianopic_visual_loss_from_chiasmal_compression_using_optical_coherence_tomography_ DB - PRIME DP - Unbound Medicine ER -