Tags

Type your tag names separated by a space and hit enter

Neuroprotective effects of lithium: implications for the treatment of Alzheimer's disease and related neurodegenerative disorders.
ACS Chem Neurosci. 2014 Jun 18; 5(6):443-50.AC

Abstract

Lithium is a well-established therapeutic option for the acute and long-term management of bipolar disorder and major depression. More recently, based on findings from translational research, lithium has also been regarded as a neuroprotective agent and a candidate drug for disease-modification in certain neurodegenerative disorders, namely, Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), and, more recently, Parkinson's disease (PD). The putative neuroprotective effects of lithium rely on the fact that it modulates several homeostatic mechanisms involved in neurotrophic response, autophagy, oxidative stress, inflammation, and mitochondrial function. Such a wide range of intracellular responses may be secondary to two key effects, that is, the inhibition of glycogen synthase kinase-3 beta (GSK-3β) and inositol monophosphatase (IMP) by lithium. In the present review, we revisit the neurobiological properties of lithium in light of the available evidence of its neurotrophic and neuroprotective properties, and discuss the rationale for its use in the treatment and prevention of neurodegenerative diseases.

Authors+Show Affiliations

†Laboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, SP, Brazil.†Laboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, SP, Brazil.‡Department of Mental Health and National Institute of Science and Technology, Molecular Medicine, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24766396

Citation

Forlenza, O V., et al. "Neuroprotective Effects of Lithium: Implications for the Treatment of Alzheimer's Disease and Related Neurodegenerative Disorders." ACS Chemical Neuroscience, vol. 5, no. 6, 2014, pp. 443-50.
Forlenza OV, De-Paula VJ, Diniz BS. Neuroprotective effects of lithium: implications for the treatment of Alzheimer's disease and related neurodegenerative disorders. ACS Chem Neurosci. 2014;5(6):443-50.
Forlenza, O. V., De-Paula, V. J., & Diniz, B. S. (2014). Neuroprotective effects of lithium: implications for the treatment of Alzheimer's disease and related neurodegenerative disorders. ACS Chemical Neuroscience, 5(6), 443-50. https://doi.org/10.1021/cn5000309
Forlenza OV, De-Paula VJ, Diniz BS. Neuroprotective Effects of Lithium: Implications for the Treatment of Alzheimer's Disease and Related Neurodegenerative Disorders. ACS Chem Neurosci. 2014 Jun 18;5(6):443-50. PubMed PMID: 24766396.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotective effects of lithium: implications for the treatment of Alzheimer's disease and related neurodegenerative disorders. AU - Forlenza,O V, AU - De-Paula,V J R, AU - Diniz,B S O, Y1 - 2014/05/06/ PY - 2014/4/29/entrez PY - 2014/4/29/pubmed PY - 2015/10/9/medline KW - Alzheimer’s disease KW - GSK-3β KW - Lithium KW - Parkinson’s disease KW - amyotrophic lateral sclerosis KW - autophagy KW - bipolar disorder KW - neuroprotection SP - 443 EP - 50 JF - ACS chemical neuroscience JO - ACS Chem Neurosci VL - 5 IS - 6 N2 - Lithium is a well-established therapeutic option for the acute and long-term management of bipolar disorder and major depression. More recently, based on findings from translational research, lithium has also been regarded as a neuroprotective agent and a candidate drug for disease-modification in certain neurodegenerative disorders, namely, Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), and, more recently, Parkinson's disease (PD). The putative neuroprotective effects of lithium rely on the fact that it modulates several homeostatic mechanisms involved in neurotrophic response, autophagy, oxidative stress, inflammation, and mitochondrial function. Such a wide range of intracellular responses may be secondary to two key effects, that is, the inhibition of glycogen synthase kinase-3 beta (GSK-3β) and inositol monophosphatase (IMP) by lithium. In the present review, we revisit the neurobiological properties of lithium in light of the available evidence of its neurotrophic and neuroprotective properties, and discuss the rationale for its use in the treatment and prevention of neurodegenerative diseases. SN - 1948-7193 UR - https://www.unboundmedicine.com/medline/citation/24766396/Neuroprotective_effects_of_lithium:_implications_for_the_treatment_of_Alzheimer's_disease_and_related_neurodegenerative_disorders_ L2 - https://dx.doi.org/10.1021/cn5000309 DB - PRIME DP - Unbound Medicine ER -