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Gasotransmitters: growing pains and joys.
Trends Biochem Sci. 2014 May; 39(5):227-32.TB

Abstract

Gasotransmitters are endogenously generated molecules of gas. Over the past decade we have come to realize that these gaseous signaling molecules are crucially important, being irreplaceable in wide biological applications. However, there are still many challenges for future gasotransmitter research to tackle. These include clarifying the interactions among gasotransmitters; understanding the significance of the cellular gasotransmitter signaling network; and adding new members to the modern family of gasotransmitters in addition to nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S). Ammonia fulfills all criteria for being a gasotransmitter, and methane is another conceivable candidate. Following the original article postulating the concept of multiple gasotransmitters over a decade ago, this sequel article aims to further inspire interest and exploration into gasotransmitter research.

Authors+Show Affiliations

Department of Biology, Cardiovascular and Metabolic Research Unit, Lakehead University, Thunder Bay, Ontario, Canada. Electronic address: rwang@lakeheadu.ca.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24767680

Citation

Wang, Rui. "Gasotransmitters: Growing Pains and Joys." Trends in Biochemical Sciences, vol. 39, no. 5, 2014, pp. 227-32.
Wang R. Gasotransmitters: growing pains and joys. Trends Biochem Sci. 2014;39(5):227-32.
Wang, R. (2014). Gasotransmitters: growing pains and joys. Trends in Biochemical Sciences, 39(5), 227-32. https://doi.org/10.1016/j.tibs.2014.03.003
Wang R. Gasotransmitters: Growing Pains and Joys. Trends Biochem Sci. 2014;39(5):227-32. PubMed PMID: 24767680.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gasotransmitters: growing pains and joys. A1 - Wang,Rui, Y1 - 2014/04/22/ PY - 2014/03/03/received PY - 2014/03/24/revised PY - 2014/03/28/accepted PY - 2014/4/29/entrez PY - 2014/4/29/pubmed PY - 2015/2/3/medline KW - ammonia KW - carbon monoxide KW - gasotransmitter KW - hydrogen sulfide KW - methane KW - nitric oxide SP - 227 EP - 32 JF - Trends in biochemical sciences JO - Trends Biochem Sci VL - 39 IS - 5 N2 - Gasotransmitters are endogenously generated molecules of gas. Over the past decade we have come to realize that these gaseous signaling molecules are crucially important, being irreplaceable in wide biological applications. However, there are still many challenges for future gasotransmitter research to tackle. These include clarifying the interactions among gasotransmitters; understanding the significance of the cellular gasotransmitter signaling network; and adding new members to the modern family of gasotransmitters in addition to nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S). Ammonia fulfills all criteria for being a gasotransmitter, and methane is another conceivable candidate. Following the original article postulating the concept of multiple gasotransmitters over a decade ago, this sequel article aims to further inspire interest and exploration into gasotransmitter research. SN - 0968-0004 UR - https://www.unboundmedicine.com/medline/citation/24767680/Gasotransmitters:_growing_pains_and_joys_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0968-0004(14)00051-6 DB - PRIME DP - Unbound Medicine ER -