Abstract
Gasotransmitters are endogenously generated molecules of gas. Over the past decade we have come to realize that these gaseous signaling molecules are crucially important, being irreplaceable in wide biological applications. However, there are still many challenges for future gasotransmitter research to tackle. These include clarifying the interactions among gasotransmitters; understanding the significance of the cellular gasotransmitter signaling network; and adding new members to the modern family of gasotransmitters in addition to nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S). Ammonia fulfills all criteria for being a gasotransmitter, and methane is another conceivable candidate. Following the original article postulating the concept of multiple gasotransmitters over a decade ago, this sequel article aims to further inspire interest and exploration into gasotransmitter research.
TY - JOUR
T1 - Gasotransmitters: growing pains and joys.
A1 - Wang,Rui,
Y1 - 2014/04/22/
PY - 2014/03/03/received
PY - 2014/03/24/revised
PY - 2014/03/28/accepted
PY - 2014/4/29/entrez
PY - 2014/4/29/pubmed
PY - 2015/2/3/medline
KW - ammonia
KW - carbon monoxide
KW - gasotransmitter
KW - hydrogen sulfide
KW - methane
KW - nitric oxide
SP - 227
EP - 32
JF - Trends in biochemical sciences
JO - Trends Biochem Sci
VL - 39
IS - 5
N2 - Gasotransmitters are endogenously generated molecules of gas. Over the past decade we have come to realize that these gaseous signaling molecules are crucially important, being irreplaceable in wide biological applications. However, there are still many challenges for future gasotransmitter research to tackle. These include clarifying the interactions among gasotransmitters; understanding the significance of the cellular gasotransmitter signaling network; and adding new members to the modern family of gasotransmitters in addition to nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S). Ammonia fulfills all criteria for being a gasotransmitter, and methane is another conceivable candidate. Following the original article postulating the concept of multiple gasotransmitters over a decade ago, this sequel article aims to further inspire interest and exploration into gasotransmitter research.
SN - 0968-0004
UR - https://www.unboundmedicine.com/medline/citation/24767680/Gasotransmitters:_growing_pains_and_joys_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0968-0004(14)00051-6
DB - PRIME
DP - Unbound Medicine
ER -